What Makes Genetically Identical Hairs On Head Respond Differently To Dht ?

[Mandar kumthekar]

Hairs on the head are genetically identical and they respond differently to DHT. What is that makes genetically identical hairs to behave paradoxically to DHT? Is there some unknown factors that are into play? Why the hair on the back of the head never falls ?
Could it be that each hair gets its different characteristic during embryo genesis? What that characteristics would be?

 

[Armando Jose]

hairs on top are less in contact with an absorvent surface, even more when they are short

IMO

 

[kiwipilu]

There is no answer to that question as we speak. You can also have thinning in safe zone / donor area. I had myself a consultation with a hair transplant doctor a while ago and he saw with a proscope I had few miniaturized hairs at the back of my head and I was only in the early stage of my male pattern baldness and have a anterior pattern which is even odder.. so you can easily guess how much miniaturization is going on when you are a high norwood and aging. There is no "safe" zone on the head, but just safer zone(horseshoe)...

 

[Mandar kumthekar]

No, they are not. That's why they respond differently to DHT.

Another thread of broscience.

Each cell of human contain same DNA ,so it is not bioscience it is fact. And how can you explain genetic differences in individuals hair BC they belong to same person.

 

[Cymro27]

I don't want to sound like a douche.. but you may aswell ask why are some cells brain cells and some cells skin in different areas of the body when they have the same DNA.

 

[Hairicane]

I don't think all hairs on you head are generally identical. Some of mine (what's left of them) curl in different ways and some are black, a few blond, and at my age some are grey. I've never heard that they are all identical.

 

[NotInmywatch]

I don't think all hairs on you head are generally identical. Some of mine (what's left of them) curl in different ways and some are black, a few blond, and at my age some are grey. I've never heard that they are all identical.

all of them have the same DNA sequence, that's why authorities can identify you by analizing any single hair that you leave in the crime scene.
these same genes can also (probably) represent a "balding map" defining androgen sensitive areas. think of it as a very detailed hair loss blueprint that resides in every cell of your body
also, studies made on identical twins give an idea that there's also a probable epigenetic component
https://www.ncbi.nlm.nih.gov/pubmed/23306311

 

[Hairicane]

all of them have the same DNA sequence, that's why authorities can identify you by analizing any single hair that you leave in the crime scene.
these same genes can also (probably) represent a "balding map" defining androgen sensitive areas. think of it as a very detailed hair loss blueprint that resides in every cell of your body
also, studies made on identical twins give an idea that there's also a probable epigenetic component
https://www.ncbi.nlm.nih.gov/pubmed/23306311

all of them have the same DNA sequence, that's why authorities can identify you by analizing any single hair that you leave in the crime scene.
these same genes can also (probably) represent a "balding map" defining androgen sensitive areas. think of it as a very detailed hair loss blueprint that resides in every cell of your body
also, studies made on identical twins give an idea that there's also a probable epigenetic component
https://www.ncbi.nlm.nih.gov/pubmed/23306311

I think can only positively identify an individual if they get the dermal papilla, hair itself contains no dna. I think. Could be wrong.

 

[NotInmywatch]

I think can only positively identify an individual if they get the dermal papilla, hair itself contains no dna. I think. Could be wrong.

only the hair follicle has DNA, I thought that part was obvious so I didn't mention it.

 

[Hairicane]

only the hair follicle has DNA, I thought that part was obvious so I didn't mention it.

But then shouldn't each hair be identical?

 

[NotInmywatch]

But then shouldn't each hair be identical?

no, that's not how it works. DNA has the instructions for the entire body, including which cells express which genes in which body regions.
that's the reason toenails grow much slower than fingernails despite having the same DNA

 

[Hairicane]

no, that's not how it works. DNA has the instructions for the entire body, including which cells express which genes in which body regions.
that's the reason toenails grow much slower than fingernails despite having the same DNA

So the guy I responded to was wrong. Each individual hair has its own dna, its own little segment of it, telling how to make it. Each hair is not identical, the dna for each isn't the same.

 

[ToLGuy]

Hairs on the head are genetically identical and they respond differently to DHT. What is that makes genetically identical hairs to behave paradoxically to DHT? Is there some unknown factors that are into play? Why the hair on the back of the head never falls ?
Could it be that each hair gets its different characteristic during embryo genesis? What that characteristics would be?

Before answering, note that this question can be expanded to ANY CELL of the human body. Every cell within an individual have virtually the same DNA, yet we have hundreds of vastly different cell types, making up vastly different tissues: from neurons to muscle fibers to white blood cells (each of them are totally different cell types in term of morphology and function). Why are they so different when they have the same DNA? The short answer is simple: differential gene expression. Each cell type have its own pattern of turned on and turned off genes, so that the transducted proteins and translated regulatory RNA molecules vary between cells, and consequently they are physically different. Individuals with androgenetic alopecia have their follicles expressing some genes in the balding prone area that are probably not being expressed in their "safe" area. Those genes are probably the ones involved in DHT sensivity (up regulation of androgen receptors??).

 

[Mandar kumthekar]

So it is down to different gene expression profile of individual hair follicle.

 

[orange86]

To me there must be a difference in dht sensitive hair to back of the head hair.

That makes sense, same DNA but the genes express differently in back of the head. Maybe the gene for AR sensitivity is not expressed.

 

[Mandar kumthekar]

To me there must be a difference in dht sensitive hair to back of the head hair.

That makes sense, same DNA but the genes express differently in back of the head. Maybe the gene for AR sensitivity is not expressed.

My next question would be why there is different gene expression on the same scalp. In many case you can see hairs dense as hell just near complete bald area. Why would nature was so precise in trait which is completely useless.

 

[BalderBaldyBald]

"Epigenetic changes modify the activation of certain genes, but not the genetic code sequence of DNA. The microstructure (not code) of DNA itself or the associated chromatin proteins may be modified, causing activation or silencing. This mechanism enables differentiated cells in a multicellular organism to express only the genes that are necessary for their own activity. Epigenetic changes are preserved when cells divide. Most epigenetic changes only occur within the course of one individual organism's lifetime; however, these epigenetic changes can be transmitted to the organism's offspring through a process called transgenerational epigenetic inheritance. Moreover, if gene inactivation occurs in a sperm or egg cell that results in fertilization, this epigenetic modification may also be transferred to the next generation."

https://en.wikipedia.org/wiki/Epigenetics#Molecular_basis

 

[orange86]

If you go back in evolution, does the Male pattern baldness shape change between dht affected hair vs dht resistance hair ?

I'd like to see how male pattern baldness shape changes through evolution

 

[BalderBaldyBald]

If you go back in evolution, does the Male pattern baldness shape change between dht affected hair vs dht resistance hair ?

I'd like to see how male pattern baldness shape changes through evolution

As far as we know, so when writing, painting and sculpting was available, it always has been this good ol' Norwood pattern.
This is a very old disease, maybe even when we were still primates playing with poop in jungles.

Fact is, primates and some felines still share this curse too, we are not the only species with it

 

[Mandar kumthekar]

"Epigenetic changes modify the activation of certain genes, but not the genetic code sequence of DNA. The microstructure (not code) of DNA itself or the associated chromatin proteins may be modified, causing activation or silencing. This mechanism enables differentiated cells in a multicellular organism to express only the genes that are necessary for their own activity. Epigenetic changes are preserved when cells divide. Most epigenetic changes only occur within the course of one individual organism's lifetime; however, these epigenetic changes can be transmitted to the organism's offspring through a process called transgenerational epigenetic inheritance. Moreover, if gene inactivation occurs in a sperm or egg cell that results in fertilization, this epigenetic modification may also be transferred to the next generation."

https://en.wikipedia.org/wiki/Epigenetics#Molecular_basis

So male pattern baldness is epigenetic in nature ? What would be the mode of therapy to change the epigenetic changes that already sets in ? I mean their at drugs which could change epigenetics.