- Reaction score
- 6,428
By the way if the hypothesis of Kythera is correct there is no need for any compound that modulates androgens or the androgen receptor. You simply could get away with a very strong DP2 antagonist and maintain your hair just as well as current maintenance treatments do and probably better seeing the strong DP2 antagonists we have. It's simply a chain. Androgens > AR function upstream, confirmed and a fact. If you either remove androgens or AR, Androgenetic Alopecia can't persist. If the hypothesis of Kythera is correct this would make the chain; Androgens > AR > PTGDS> PGD2 > DP2 >>>> hair loss. So when you would strongly antagonize the DP2 receptor there would be no need for finasteride. That's why I challenged you to drop the finasteride.
We'll need a better DP2 antagonist than Setipiprant imo. There's a load currently in development. Pulmagen's ADC3680 for example.
Pulmagen believes that ADC3680 is the only truly low dose (< 10 mg), once daily, CRTh2 antagonist in clinical development and is positioned to be ‘best in class’ with the potential to be first to market.
Now find me that formula!