Aren't you using darolutamide, a drug intended for castration resisted prostate cancer that's still in trials? You could argue the same that in 2-5 years you could have unforeseen side effects.
Sort of. Daro is an androgen receptor antagonist. We've had androgen receptor antagonists for decades. We know what they generally as a class do and don't do. It's not a new drug class. If I want to read about the general risks of androgen receptor antagonism, there are many years of studies on flutamide, nilutamide, bicalutamide, topilutamide, and now enzalutamide and apalutamide.
Daro is the newest in the family, but the family is well known and they are all somewhat similar in their risks. The only thing particularly unique about daro is that it doesn't cross the blood brain barrier, which if anything should make it theoretically safer than the rest of its family members. It's possible some metabolic breakdown product of daro will turn out to be uniquely toxic, but I doubt it, and I am only using 1% of the doses that are used for prostate cancer (since I'm using it topically), so this doesn't worry me. It is stronger than other anti-androgens too and we have no long term data on it, so it's hard to say for sure.
These risks and unknowns are why I try not to encourage anyone else to use daro. While I'm happy that it has worked well for me without too many problems so far, I try to discourage too much enthusiasm about the drug in general and especially in people who aren't aware of the uncharted waters it might represent.
So I don't think I'm being selective or unfair in what I'm saying about seti/fevi. The reality is: no one really knows what PGD2 inhibition does throughout the body long term. We don't have long term PGD2 deprivation studies, like we have long term androgen deprivation studies.
Maybe it's nothing. Maybe it's no worse than taking an anti-histamine every day. That would be fantastic.
But sometimes the unknown turns out bad. eg. My dad takes pantoprazole for his heartburn. Everyone thought that was a great new type of drug when it came out. Now that we have some longer data, they say it increases your risk of stroke, so he's trying to stop.
I bet when finasteride hit the market in 1992 people thought it was a miracle. A drug that can cure hair loss! Amazing! Who could complain? I doubt anyone would have guessed that 26 years later people would be angrily complaining about its effects on neurosteroids etc. and trying to build a case that it is a permanently damaging drug.
Who knows what people will be saying about PGD2 inhibitors in 26 years? I don't know. I know some people have already noted sleep disruption on it. I am a poor sleeper to begin with. So that makes me personally nervous. Are people gonna say in 26 years PGD2 inhibition ruined their sleep centers so now they can't sleep at all?
Again, I truly don't know. I'm not trying to fear monger these drugs. If they are proven to work and be safe, it will be an incredible new class. Your results sound great. But when you're inhibiting a signal chain that's never been inhibited before, and we already know that it has effects on the brain, that makes me a little nervous.
I'd rather the devils I know than the devils I don't. I don't like unknown compounds. I prefer to only go that route when it's absolutely necessary. In my case it was necessary as finasteride and dutasteride don't work on me, so my choices were to try something different or go bald.
