Let me rephrase: estradiol does not effect it negatively.
Estradiol and progesterone levels vary along the menstrual cycle and have multiple neuroactive effects, including on the dopaminergic system. Dopamine relate...
www.frontiersin.org
>In particular, estradiol seems to have a special impact on the dopaminergic system. Animal research has demonstrated numerous genomic and non-genomic estradiol effects on functional activity modulating DA. It increases the synthesis, release, reuptake and turnover of DA, affects downstream targets of its receptor and modifies basal firing rates of dopaminergic neurons
Abstract. Research in basic neuroscience has provided biological plausibility for the hypothesis that estrogen replacement therapy (ERT) would protect agai
academic.oup.com
>No differences occurred between scores of women given E2 valerate, 2 mg, or placebo daily on the Integration Memory Test, on a test of logical thinking, or on a reaction time task