Yes. Topical skips first pass metabolism. When you ingest it, it is processed through the use of an enzyme, sulfotransferase, which turns minoxidil into its active form, minoxidil sulfate. Much more of the active form is produced when it is ingested. However, the use of the topical skin treatment, tretinoin (retin-A), can also increase levels of the enzyme in the skin. So you could do that if you had some on hand. Regardless, oral appears to be superior in terms of results.Thanks man! Is there any reason as to why ingesting min works alot better than topical?