- Reaction score
- 1,336
Winlevi ( Cb 03 01 ) For Acne, Fda Approval
- Thread starter Seuxin
- Start date
- Reaction score
- 1,336
Pricing will be disclosed in the fourth quarter of 2020. On March 31, H.C. Wainwright & Co. analyst Raghuram Selvaraju wrote that Cassiopea was not planning to price the drug above $600 per patient. Selvaraju noted that recent acne drug launches, such as Aklief (trifarotene 50 mcg/g cream), a retinoid molecule, are priced in about the $475 to $550 range.
So WinLevi 1% for less than $600. A bargain I wonder how much for Breezula. 7.5%.
So WinLevi 1% for less than $600. A bargain I wonder how much for Breezula. 7.5%.
- Reaction score
- 907
aklief is good? i have a prescription for it( 40 euros here)
- Reaction score
- 1,336
I am not sure if it works for hair but assuming it does.
At 50 mcg/g you will need 7-10 times the dosage for hair if you replicate WinLevi Breezula ratio. If you use twice the dosage you would use for acne to cover bald areas it's about a dozen tubes or ~$500 euros a month. We are back to Breezula anticipated cost (assuming WinLevi and Breezula are price in the same zone.)
$600 per tube? That's insane.
- Reaction score
- 60
Hey in terms of using CB over RU, if buying from kane for $50/g and mixing 7.5% for 1ml/day then it is not too pricey? $3.75/day I think, might be wrong, new to this. In their studies with 1% cream it was quickly metabolized into an inactive compound in the bloodstream but I don't know how true that would be for 7.5%. As I got ED from RU going systemic at 5%, I was curious if CB from kane would be my next AA. I know in your success post you recommended estriol but I am also worried of that easily going systemic with me. Currently dropping RU to 3% and applying 0.5ml on half a scalp i morning and 0.5ml on the other half at night. Hoping that absorbing 15mg per take wont effect my dck this time.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177662/ - 1% test
https://tophairlosstreatments.com/cb0301-phase-2-results/ - phase 2 results?
I spoke with my derm, who conducted the winlevi trials coincidentally. He can and will happily give me as much winlevi as I want to apply to my scalp, but it's unlikely compounding pharmacies will have access to the raws which is unfortunate.
We can hope prices drop in China due to supply/demand, but the drug will be made in Italy, so who knows.
Btw, I've used REAL (not Chinese Kane flour) RU and CB extensively. 2% CB is much effective than 5% RU. Perhaps there's something unique about my hairloss that responds well to the corticosteroid effect, as there's no other biochemical reason why this should be the case (RU is a more effective receptor blocker).
We can hope prices drop in China due to supply/demand, but the drug will be made in Italy, so who knows.
Btw, I've used REAL (not Chinese Kane flour) RU and CB extensively. 2% CB is much effective than 5% RU. Perhaps there's something unique about my hairloss that responds well to the corticosteroid effect, as there's no other biochemical reason why this should be the case (RU is a more effective receptor blocker).
- Reaction score
- 96
What makes you say your ru and cb are real and the chemicals Kane sells are fake?
Because we spent months making multiple batches, testing each until one met our standards. What do you think happened to the low quality batches? “Hot sale friend!!!”
- Reaction score
- 96
Ah ok, "testing" was the only word you needed to say lol.
- Reaction score
- 60
what is this real CB you speak of sir and how do I get one? or did you mean winlevi? honestly thought of getting mine from kane but after reading this got some doubts.
You also asked about Kane, and I told you. Remember during the seti craze when everyone was buying it from Kane et al, and reporting sh*t like pieces of rope and alleged rat droppings in their seti? Now that you know how hard it is to manufacture chemicals to a high standard, do you really think someone who lets rope get into their batches will waste money/time re-doing impure batches? To think that people will put this sh*t on their head is insane. If you don't have a good source, you MUST test.
On general population yeah, but not on someone on TRT or PEDs. The HPTA is already suppressed in these cases, so CB is harmless, but RU can still displace androgens throughout the body if enough will go systemic.
That being said, the numbers of the winlevi press release are worrysome to say the least for naturals. HPA (HPTA) suppression is way worse than 5-ar inhibition.
- Reaction score
- 3,659
The press release mentions HPA (adrenal) axis suppression (not HPTA - testicular) on CB (I'm not saying this is much better, just pointing out). This is likely due to the corticosteroid component - cortexolone.
https://www.cosmopharma.com/news-and-media/press-releases-and-company-news/2020/200827
Last edited:
I've already discussed about it. You can't separate the 2. The hypothalamus, pituitary gland, adrenals and gonads are all linked and they balance each other in a really elaborate way. You can't isolate the hypothalamus and the adrenals and expect no effect on testicles function.
Both HPA and HPTA are old school terms anyway, a more appropriate term would be HPG. Even Wikipedia reported HPA=HPTA. I think the guys at Cassiopea just got lost in translation, hence why I'm curious to see how they will explain it in phase 3 of Breezula.
If you mean Pyrilutamide, their website says they expect to finish enrollment for phase II in 2020, so still quite far from release.
They just said no side effects reported on phase I, but we all know that was the same they were saying with CB.
http://pdf.dfcfw.com/pdf/H3_AP202007241393752560_1.pdf
Last edited:
- Reaction score
- 3,659
The problem with CB is that it breaks down into steroidal metabolites. That is a huge fail and no idea how they didn't see these kinds of problems coming.
An anti-androgen needs to be designed to break down into completely inert (or as close as possible) components in the bloodstream. Topilutamide had a good approach with that, shame that it's so weak in practice.
Alternatively, we can forget about attempting to compete with androgens for the AR which seems like futile endeavour and instead use SARD's to reduce the amount of AR available to bind to. That seems like a better approach. Of course the rationale above still applies.
Unless this 'Pyrilutamide' magically breaks down into inactive components in the bloodstream and is more effective than CB & RU I wouldn't hold my breath for that.
"In the Pharmacokinetics studies, KX-826 and its metabolite KX-982 could be detected in plasma in a dose-dependent manner, though the concentrations were quite low."
Never mind, lol.
An anti-androgen needs to be designed to break down into completely inert (or as close as possible) components in the bloodstream. Topilutamide had a good approach with that, shame that it's so weak in practice.
Alternatively, we can forget about attempting to compete with androgens for the AR which seems like futile endeavour and instead use SARD's to reduce the amount of AR available to bind to. That seems like a better approach. Of course the rationale above still applies.
Unless this 'Pyrilutamide' magically breaks down into inactive components in the bloodstream and is more effective than CB & RU I wouldn't hold my breath for that.
"In the Pharmacokinetics studies, KX-826 and its metabolite KX-982 could be detected in plasma in a dose-dependent manner, though the concentrations were quite low."
Never mind, lol.
I agree with you and I don't know how they managed to portrait it as "safe" with the FDA and the all the customers, while 10% (!) of their patients got the axis shutdown. Insane.
That's why I'm really curious to see how they will come out of this with phase 3 of Breezula, since on Winlevi they justified it saying not to use it on "a large area" or "for an extended period of time". Tell that to an Androgenetic Alopecia sufferer.
- Reaction score
- 3,659
If it was that bad with WinLevi just imagine the shitshow of someone diffusing into NW5 trying to use 7.5% twice a day.
This drug is looking more and more useless by the day.