10-Month (& 1 Week) Dutasteride & Rogaine Results

Aplunk1

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collegechemistrystudent said:
I don't speak german, but I can read graphs, so I'll translate.

Read the key left to right then top to bottom like a page. It says 0.5mg every day, 2 out of 3 days, every other day, every third, etc, all the way to every 7th day. The graph shows the blood concentration of dutasteride after a certain number of days.

To know what levels give you protection, you need a second graph, which is on myspace, which shows how much of each type of 5ar is inhibited at various blood concentrations of dutasteride. It looks like half of a bell curve. Maybe aplunk1 will go on my web page, get the graph, and post it here, and I'll explain how to read it. If my memory is correct, 1/10th the final steady state concentratio reached by dutasteride every day is enough to give proscar like protection. The less you take each day, the longer it takes you to reach that point.

Is this what you wanted:

912696564_l.jpg
 

Bryan

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Aplunk1 said:
I've never seen this graph before.

I wouldn't take that graph too seriously. It wasn't published in a medical journal or textbook, it was just made-up by a poster on hairsite. Don't know how accurate it is.

Bryan
 

CCS

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aplunk1,
I wanted a different graph. It has a white background, and has a curve that starts high on the left side and gets low on the right side.



Bryan,
That graph predicts dutasteride should be about 33 or so at steady state, and you said in the GSK paper that it should be at 40, so it is inacruate. Also, since the half life increases with time, I'd expect the graph to start off more shallow than that, then pick up speed, and then level off. I could set up a differential equation and graph it from the info in some pharmaceutical papers. It is possible the overall shape is right, though. The jaggedness of the dutasteride graphs are very exangerated, and the proscar level should not be flat like that.
 

Bryan

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collegechemistrystudent said:
Bryan,
That graph predicts dutasteride should be about 33 or so at steady state, and you said in the GSK paper that it should be at 40, so it is inacruate.

Well, yeah, but I could understand it being off a little by about that much. Average blood levels of dutasteride might vary a bit from one group of test subjects to the next, obviously, not to mention slightly different results from different ethnic groups and even different labs that do the testing.

collegechemistrystudent said:
Also, since the half life increases with time, I'd expect the graph to start off more shallow than that, then pick up speed, and then level off.

Yeah, at least for the smaller doses. Of course, it would be helpful to be able to actually READ the color-coded doses at the bottom, and not have to guess which line is which! :D

collegechemistrystudent said:
I could set up a differential equation and graph it from the info in some pharmaceutical papers. It is possible the overall shape is right, though. The jaggedness of the dutasteride graphs are very exangerated, and the proscar level should not be flat like that.

No, it doesn't make a whole lot of sense. I pointed out problems like that when the guy first posted it on hairsite a few years ago, but nobody paid any attention. People kept re-posting it as if it were an accurate representation. The graphs that _I_ post, on the other hand, are all from medical journal studies and textbooks.

BTW, were you serious about being able to make your own graphs from the raw data that's available, like from the Gisleskog studies? If so, that would be really cool. We could have graphs tailored directly to the Avodart dosage (0.5 mg/day), without having to interpolate between 0.1 mg/day and 1 mg/day. Can you really do it?

Bryan
 
G

Guest

Guest
Hey Aplunk,

They pictures aren't there anymore. Could you reload them? I want to see that hairline you are thinking about getting a hair transplant on.
 

Aplunk1

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badasshairday said:
Hey Aplunk,

They pictures aren't there anymore. Could you reload them? I want to see that hairline you are thinking about getting a hair transplant on.

Yeah, I took them down.

I'll post some new pictures, under a new file-sharing account JUST for hairloss.


Updates will be up in a few hours.
 
G

Guest

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Like I said before I think, your hair isn't combed back in the pictures, especially in the last one, so your hairline is actually a bit farther back than it appears in the last pic. those tufts of hair in the front are not where the hairline begins. I would comb it back if you could in new pics, and then take measurements from eyebrows to forehead and eyebrows to chin. I think hair transplant docs could lower it a quarter inch and bring the temples in a bit to give you your hairline back depending on what you want, assuming your hairline was better before. Again I don't know where your natural hairline is because some people have naturally high ones but yours looks like it has receded from your childhood one. Your crown as I said looks great, top looks great combed forward. I am interested to see what your whole scalp looks like with the hair combed back, what the top and crown look like. The crown should look entirely covered with the combed back hair covering it up but I'm more interested in the top and especially the hairline location. So if you could take pics with hair combed back that would be great- it's easier to do this with wet hair of course.

Here's what I'm talking about, using your last pic as an example:



Basically I drew a red line across your hairline to show the approximate location of where i think the center hairline would be with it combed back pending pics from you.
 

Aplunk1

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Taken a month or two ago:

hairline.jpg


This isn't a really good shot, but it helps to show.

The recession and balding (Zone 1, according to Armani) is in red.
 

JWM

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Aplunk

Did you stop using spironolactone Cream?

Also, your hairline looks great! Seriously pal, your hair looks damn good. Go out and enjoy life.
 

Aplunk1

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JWM said:
Aplunk

Did you stop using spironolactone Cream?

Also, your hairline looks great! Seriously pal, your hair looks damn good. Go out and enjoy life.

Haha! Thanks man, these are the comments that I like to hear.

Yeah, I stopped using spironolactone, simply because I lost my last $35 tub.

If I buzz my hair in the coming months, then I'll get back on 5% spironolactone and copper peptide serum.
 
G

Guest

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Those are great shots of your hairline.

You're basically an early stage Norwood 2 in my opinion. Not quite a fully developed Norwood 2. dutasteride should maintain that for a long time. I'm not sure what I think of Armani's estimates because he gave htownballa and I the exact same frontal graft estimates and I found that weird considering I don't really have much hairline/temple recession if at all. So I would be wary if I were you. I don't think you need more than 1200 grafts to make the front look the way you want it to. He is very aggressive and I'm not sure you need 2k grafts or whatever he recommended.

Can you take pics of your crown and top with it combed back the same way you just did for those pics? Also, what are measurements of your hairline? By that I mean how many inches is it from the center base of where a unibrow would be to your center hairline. And then if you go directly left or right the inches from eyebrow to left temple and eyebrow to right temple. If the ratio from those is 50% or less than the distance from where middle of unibrow would be to your chin then I don't think you need it lowered because it is proportional. Some people just have large faces and big noses so actually a higher hairline looks better than a low one depending on measurements.

Thanks.
 

Aplunk1

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Armani recommended close to 2700 grafts between 70-80% density, including temple-closure, aggressive hairline, and tri-closure technique.


I don't have any digital pics of my hair styled, but my website has a few of my hair styled.

I'll see if I can get some measurements.

Last time I measured the hairline & face, it was difficult because I don't have a tapemeasure, just a straight ruler... It's hard to use a standard ruler on a face because of its roundness.
 
G

Guest

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dude that is a lot of grafts for an early nw2. i would get other estimates if i were you. and yeah rulers suck for measuring stuff liek this, tape measures are more flexible and better and what i use.

like i said before i don't really see the point of you getting them because dutasteride should hold your current hair in place for another 10-15 years and hM will be out by then for sure. no one can really tell you're balding yet if your hair is dry. you just look like you have a mature hairline and in 2 or 3 more years a lot of guys your age will have that.
 

CCS

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my dense hair is 60 fu per cm2 in the donor area. The 35 in front i have look really thick, though a bit thin when I part it and look close. I really think this 90 fu stuff is bs. I think you have 90 hairs, not fu's, like i have. That is what dr keene told me too. I asked them what my density was when they were cutting up the donor strip. 85 was the number. I'm just going to get 50 in front and that should look really good even parted up close.

I think an advantage of FUE is the hairs in telogen don't get missed and tossed. But as for the visible hairs, it is riskier. I'm not sure if it balances out. I'll need 5000 total to go from NW3 to nw1. You want to go from Norwood 2.5 to NW2. So 2700 sounds like a bit much, but in reason if you actually get 90 grafts. Dr Keene thinks he splits them into individual hairs and calls each a graft if he is doing that many. Hair looks more natural if it has the naturally occuring groups of 1-3 hairs, so it matches the rest of your hair, if anyone ever looks that close.
 

Renegade

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That's it - I'm getting on dutasteride as soon as my finasteride runs out!

Aplunk...you suck! (J/K)

Seriously though, transplants at your degree of hairloss is just crazy talk!
 

Aplunk1

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Renegade said:
That's it - I'm getting on dutasteride as soon as my finasteride runs out!

Aplunk...you suck! (J/K)

Seriously though, transplants at your degree of hairloss is just crazy talk!

Haha, noooiiice, man!

I never would have imagined that I could get people to use a successful treatment like dutasteride!

Thanks for the positive comments!
 

bubka

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nice improvements (though i didn't really see the before) but looks pretty decent man :thumbs_up:

whats that yellow crap on the one pic?
 
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