A Closer Look At: SHBG & Metabolic Clearance.
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OverMachoGrande
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
I proved you wrong, Watson, plus you didn't answer my question about the S.H.B.G. receptor. In fact with all this "knowledge" about hair, surly you could shed some light on S.H.B.G. You seem to be lost for words. You seldom waste your time on subjects (like S.H.B.G.) in which I can prove you wrong. That explains your overall absence and lack of argument in regards to S.H.B.G.
I proved you wrong, Watson, plus you didn't answer my question about the S.H.B.G. receptor. In fact with all this "knowledge" about hair, surly you could shed some light on S.H.B.G. You seem to be lost for words. You seldom waste your time on subjects (like S.H.B.G.) in which I can prove you wrong. That explains your overall absence and lack of argument in regards to S.H.B.G.
Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
Bryan... Maybe these "balding follices" are badly damaged and therefore predisposed/programmed to go dormant where ever they are relocated?
I find your tone very patronising.. this guy is just dicussing his theory on an issue. Funnily enough this is how science and understanding develops. All those studies which you cite so to reinforce your supiority were all once theories.
"Imagination is more important than knowledge. For knowledge is limited to all we now know and understand, while imagination embraces the entire world, and all there ever will be to know and understand"
Bryan... Maybe these "balding follices" are badly damaged and therefore predisposed/programmed to go dormant where ever they are relocated?
I find your tone very patronising.. this guy is just dicussing his theory on an issue. Funnily enough this is how science and understanding develops. All those studies which you cite so to reinforce your supiority were all once theories.
"Imagination is more important than knowledge. For knowledge is limited to all we now know and understand, while imagination embraces the entire world, and all there ever will be to know and understand"
OverMachoGrande
Senior Member
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
Now thats a good quote! :bravo:
n0142248 said:
Now thats a good quote! :bravo:
waynakyo
Experienced Member
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
It 's a while now that this section has been quite hijacked by Mister E.
Bringing an article from 1998 and misinterpreting it and sending conversations on the wrong foot... and what is more, insisting that he is correct. It's not thoughtful to tell people to stack on "x" oil or whatever because of your interpretation of one study. I would instead try it first and only pictures are powerful on this forum (well, the experimental one).
cheers
It 's a while now that this section has been quite hijacked by Mister E.
Bringing an article from 1998 and misinterpreting it and sending conversations on the wrong foot... and what is more, insisting that he is correct. It's not thoughtful to tell people to stack on "x" oil or whatever because of your interpretation of one study. I would instead try it first and only pictures are powerful on this forum (well, the experimental one).
cheers
OverMachoGrande
Senior Member
- Reaction score
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
Which article are you refering to, and what do you not agree with?
waynakyo said:
Which article are you refering to, and what do you not agree with?
OverMachoGrande
Senior Member
- Reaction score
- 43
If You would like to learn more about the SHBG-receptor, you can do so here: http://books.google.com/books?q=SHBGR&btnG=Search+Books and here: http://books.google.com/books?q=RSHBG&btnG=Search+Books
OverMachoGrande
Senior Member
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
By the way C18= Estrogens. C19=Androgens
Titre du document / Document title
Structure/function analyses of human sex hormone-binding globulin: effects of zinc on steroid-binding specificity
Auteur(s) / Author(s)
HAMMOND Geoffrey L. (1) ; AVVAKUMOV George V. (1) ; MULLER Yves A. (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Departments of Obstetrics & Gynecology and Pharmacology & Toxicology, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, The University of Western Ontario, London, Ont., N6A 4L6, CANADA
(2) Department of Biochemistry, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, ROYAUME-UNI
Résumé / Abstract
In humans, sex hormone-binding globulin (SHBG) binds and transports the biologically most important androgens and estrogens in the blood, and regulates the access of these steroids to their targets tissues. In addition to binding sex steroids, SHBG has specific binding sites for divalent cations including calcium and zinc. Zinc binding to a site at the entrance of the steroid-binding pocket in human SHBG has been shown to reduce its affinity for estrogens, while having no impact on the binding of C19 steroids. Crystallographic studies indicate that C18 and C19 steroids are bound in opposite orientations within the SHBG steroid-binding site, and we have obtained new information that supports a molecular model explaining the mechanism by which zinc alters the affinity of human SHBG for estrogens, by studying directly the estradiol-binding properties SHBG variants created by site-directed mutagenesis. In this model, the coordination of a zinc ion by the side chains of residues Asp65 and His136 eliminates a critical hydrogen bond between Asp65 and the hydroxyl at C3 of estrogens, such as estradiol and 2-methoxyestradiol, and causes disorder in a polypeptide loop segment that covers the steroid-binding site. The combination of these structural changes explains the specific decrease in the affinity of human SHBG for C18 steroids in the presence of a zinc ion.
misterE said:
By the way C18= Estrogens. C19=Androgens
Titre du document / Document title
Structure/function analyses of human sex hormone-binding globulin: effects of zinc on steroid-binding specificity
Auteur(s) / Author(s)
HAMMOND Geoffrey L. (1) ; AVVAKUMOV George V. (1) ; MULLER Yves A. (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Departments of Obstetrics & Gynecology and Pharmacology & Toxicology, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, The University of Western Ontario, London, Ont., N6A 4L6, CANADA
(2) Department of Biochemistry, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, ROYAUME-UNI
Résumé / Abstract
In humans, sex hormone-binding globulin (SHBG) binds and transports the biologically most important androgens and estrogens in the blood, and regulates the access of these steroids to their targets tissues. In addition to binding sex steroids, SHBG has specific binding sites for divalent cations including calcium and zinc. Zinc binding to a site at the entrance of the steroid-binding pocket in human SHBG has been shown to reduce its affinity for estrogens, while having no impact on the binding of C19 steroids. Crystallographic studies indicate that C18 and C19 steroids are bound in opposite orientations within the SHBG steroid-binding site, and we have obtained new information that supports a molecular model explaining the mechanism by which zinc alters the affinity of human SHBG for estrogens, by studying directly the estradiol-binding properties SHBG variants created by site-directed mutagenesis. In this model, the coordination of a zinc ion by the side chains of residues Asp65 and His136 eliminates a critical hydrogen bond between Asp65 and the hydroxyl at C3 of estrogens, such as estradiol and 2-methoxyestradiol, and causes disorder in a polypeptide loop segment that covers the steroid-binding site. The combination of these structural changes explains the specific decrease in the affinity of human SHBG for C18 steroids in the presence of a zinc ion.