Actual picture of the biodegradable scaffold Stemson is using for hair cloning

[werefckd]

Posted for the first time in the forums?!

The scaffold is a very important part of the puzzle: they are what holds the follicle generating cells together (the seed) and control the direction of the hair growth (ultra important for it to look natural).

They call the scaffold (they invented?) a "lolli-up". They fill it with dermal papilla and epithelial stem cells derived from iPS cells then implant into the scalp.

The second picture is from something they call a "micro wall". It's has many lolli-ups together and they use it during the filling stage. When it comes to the implantation stage I believe they insert each lolli-up individually in the skin (but I'm not sure).

Those pictures are from 2019 so they may have evolved the design already.

 

[werefckd]

By the way, Dr. Terskikh won't pull a Tsuji because he is one of us.
He won't stop working on that stuff like a mad man until he delivers the cure!

 

[werefckd]

Cloning shitty hairs: done!
Cloning natural looking hairs: in development (hopefully)

 

[kiwi666]

It’s nice to see pics like this. Has he tried implanting these in his own skin?

 

[kiwi666]

Also... there are two types of “shitty” hairs as well.

There’s acceptable shitty that I can dye and style - even mix around and behind nice transplanted hairs.

Then there is not acceptable shitty. Hairs that are ingrown. Don’t grow beyond a certain length.

I don’t even care if they are only black it grey if I can dye them.

Hopefully he gets this.

There are people here that would let him try implanting hairs (lollie-ups) on our arms / hands tomorrow.

 

[Will Be an Egg in 5 years]

That's f*****g amazing actually, even If It took decades to became true.

They cloned a damn sheep, no way cloning hair folicles is that hard.

 

[werefckd]

they didnt use human epithelial cells......

In the beginning of their research no, because their team was small and they focused on the novelty part of the science, which was deriving dermal papilla cells from iPSC for the first time ever.

But it changed since them, their team is much bigger and better funded now, and according to a direct 2019 quote from Antonella Pinto, their lead researcher, they are working with human epithelial stem cells now too:

"The first step in our experimental design was to develop a NEW protocol do derive dermal papilla cells from the human pluripotent stem sells and to optimize already existing protocols to originate epithelial stem cells from induced pluripotent potent stem cells"

 

[BaldAndBalder]

it always looks good on paper, we will see after human trials

When?

 

[werefckd]

I would guess second half of 2022 if everything goes well.

 

[werefckd]

what's the difference between this and the stemson approach?
"In the third generation technology, hair follicles and skin are engineered from induced pluripotent stem cells: this approach benefits patients with congenital alopecia, who lack healthy follicles, or severe baldness, who have almost none. These three generations of hair regeneration technology have paved the way for a new healthcare paradigm in which all types of hair loss are treatable."

Same approach. You took that from the Organ website. Their plan was to eventually use iPSC in the future, like Stemson is using now.

 

[werefckd]

they probably don't know when

After they announced their $7.5M seed financing round back in September, Geoff said they were aiming to start clinical trials within 16 months.

They don't have any revenues so they need to show meaningful progress within the next 2 years to be able raise another round or else they will run out of money and close shop like Organ. They can't afford to be slow.

That's why I believe they better be ready to start clinical trials by the second half of 2022 or else they will be in deep trouble.

 

[werefckd]

I thought they were developing these three methods at the same time and they are going to introduce them at the same time, unfortunately I am also balding on the back of my head so stemson is the best for me

at the end of the day the best method is the one that works!

 

[werefckd]

better if they start human research in 2021

I got a feeling that there is a zero chance that they start human trials in 2021. But it would be nice if they could get at least a proof of concept in humans next year.

 

[eeyore]

That's pretty interesting, didn't know there were pictures of it online. Where did you find them?

Apparently they've already successfully cloned hair and transplanted them onto a mouse last year? I thought Stemseon was still way before that step.

 

[werefckd]

That's pretty interesting, didn't know there were pictures of it online. Where did you find them?

Apparently they've already successfully cloned hair and transplanted them onto a mouse last year? I thought Stemseon was still way before that step.

Yea they did it last year.

I got the pictures from a presentation their lead researcher, Antonella Pinto, did in the beginning of 2019. It's on YouTube but apparently the video didn't get noticed by anyone in the blogs/forums until now as far as I know.

 

[Eazy12]

but at what cost

 

[werefckd]

no cost since there is no product yet - still in development, lots of technical challenges to be solved still.

But I'm certain it won't be cheap and it won't be for the masses for some time after it gets on the markets.

 

[kiwi666]

no cost since there is no product yet - still in development, lots of technical challenges to be solved still.

But I'm certain it won't be cheap and it won't be for the masses for some time after it gets on the markets.

Getting to the markets is a very very very big IF

 

[jan_miezda]

i wonder what are the long term efect of the biodegradable scaffold? for people that will have thousands of them implanted

 

[werefckd]

i wonder what are the long term efect of the biodegradable scaffold? for people that will have thousands of them implanted

yea, even if they are bio degradable (organic or synthetic?) imagine having 20 THOUSAND of these tiny little structures implanted into your scalp all at once and very close together, could the skin handle it?

That's why they need to go from experiments in mice to full blown pre clinical studies with large animals as soon as possible. There are so many variables with this kind of revolutionizing treatment,