- Reaction score
- 197
Hopefully we have some control subjects using nothing else at the moment or just fina to target DHT.
Using KY with minoxidil is bound to have a synergystic effect....
Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss
- Thread starter Ollie
- Start date
Hopefully we have some control subjects using nothing else at the moment or just fina to target DHT.
Using KY with minoxidil is bound to have a synergystic effect....
Do you think we'll have a future opportunity to get KY and SMI if we didn't get them in the first round or didn't buy enough?
If it actually has positive effects, there will be plenty of opportunities because everyone will want it and those that already have it will want more of it.
Definitely. KY will be widely available soon. If SMI works it will be too.
What's the pricing like on KY? What dosing schedule will you guys be trialing?
The price will come down, but to start with if you only get 1g or less it's going to be close to $1k for a gram. It lasts a long time. Most people are using a similar dose to SM.
Isn't SM 0.15mg/ml? Why would you even need a gram at that dosage?
No, SM is 1.5mg/ml. I'm using KY at 1mg/ml. At 2ml/day that's 500 days.
Ah woops, got it. 2$ a day is pretty reasonable for something like this. Have you guys already ordered?
Awesome. Looking forward to hearing the results.
- Reaction score
- 614
We're using 1%, but we have no point of reference. How long it lasts also depends on the area since this is "minitherapy"
- Reaction score
- 214
Is everyone using the same percentage? Maybe certain users can use higher or lower percentages to help find an "optimal" if it exists.
Some will keep up-titrating the dose as long as there are no side effects
- Reaction score
- 614
Maybe some will be more adventurous, I know I'm increasing the conc if I don't notice anything in 3 months
It's a prolactin receptor antagonist.
- Reaction score
- 292
Relevant article from 2020
The mechanism whereby prolactin directly regulates hair growth is connected with its inhibitory influence on hair shaft elongation and the premature induction of the catagen phase (causes miniaturization). Moreover, luteotropin (Prolactin) also plays a significant role in the proliferation and apoptosis of keratinocytes in HFs by decreasing the number of Ki-67-positive cells and increasing the quantity of TUNEL + cells [18]. Prolactin is recognized as an androgen metabolism modulator. The luteotropic hormone seems to increase the level of free testosterone and dehydroepiandrosterone sulfate, decreasing at the same time the level of serum testosterone-estradiol-binding globulin [24,25]. PRL also appears to inhibit the activity of 5-alpha
this is interesting beacause it mentions a prolactin receptor on the outer root sheath region of the hair follicle. There can be a lot of pharmaceutical approaches for blocking its activity. But this is hard because the external root sheath is inside a glossy membrane. It will be hard for the molecule to interact with that receptor. It also says prolactin inhibits 5ar activity.I know in men and women prolactin causes increased expression of estrogen receptors this can be a good reason why miniaturization is much slower in women:
“The ability of the rat corpus luteum to respond to estrogen requires prolactin (PRL), which can stimulate the expression of the estrogen receptor (ER).”
pubmed.ncbi.nlm.nih.gov
The mechanism whereby prolactin directly regulates hair growth is connected with its inhibitory influence on hair shaft elongation and the premature induction of the catagen phase (causes miniaturization). Moreover, luteotropin (Prolactin) also plays a significant role in the proliferation and apoptosis of keratinocytes in HFs by decreasing the number of Ki-67-positive cells and increasing the quantity of TUNEL + cells [18]. Prolactin is recognized as an androgen metabolism modulator. The luteotropic hormone seems to increase the level of free testosterone and dehydroepiandrosterone sulfate, decreasing at the same time the level of serum testosterone-estradiol-binding globulin [24,25]. PRL also appears to inhibit the activity of 5-alpha
this is interesting beacause it mentions a prolactin receptor on the outer root sheath region of the hair follicle. There can be a lot of pharmaceutical approaches for blocking its activity. But this is hard because the external root sheath is inside a glossy membrane. It will be hard for the molecule to interact with that receptor. It also says prolactin inhibits 5ar activity.I know in men and women prolactin causes increased expression of estrogen receptors this can be a good reason why miniaturization is much slower in women:
“The ability of the rat corpus luteum to respond to estrogen requires prolactin (PRL), which can stimulate the expression of the estrogen receptor (ER).”
Prolactin regulation of estrogen receptor expression - PubMed
The ability of the rat corpus luteum to respond to estrogen requires prolactin (PRL), which can stimulate the expression of the estrogen receptor (ER). This review will focus on the signaling mechanisms by which this occurs. Transcription of the genes encoding both ERalpha (Esr1) and ERbeta...
pubmed.ncbi.nlm.nih.gov
Last edited:
- Reaction score
- 292
Prolactin receptor expression is also closely tied to serum GH. This study shows for group B (20-40 years old) as GH receptor expression declines PRLC expression increases. This can be why younger kids dont experience hair loss. As we age IGF - receptor reactivity in hair follicles declines in balding people.
pubmed.ncbi.nlm.nih.gov
Growth hormone (GH) and prolactin receptors in human peripheral blood mononuclear cells: relation with age and GH-binding protein - PubMed
GH receptors (GHRs) and PRL receptors (PRLRs) were studied in human peripheral blood mononuclear cells (PBMC) using flow cytometry, biotinylated anti-GH receptor monoclonal antibody 10B8, and biotinylated human PRL. Variations of GHR and PRLR expression and the relationship of plasma GHBP and GH...
pubmed.ncbi.nlm.nih.gov
- Reaction score
- 582
"Prolactin acquires antiangiogenic properties after undergoing proteolytic cleavage to vasoinhibins, a family of PRL fragments (including 16 kDa PRL) with potent antiangiogenic, vasoconstrictive, and antivasopermeability effects."
Clapp, C., Thebault, S., Macotela, Y., Moreno-Carranza, B., Triebel, J., & Martinez de la Escalera, G. (2015). Regulation of blood vessels by prolactin and vasoinhibins. Adv Exp Med Biol, 846, 83-95. doi:10.1007/978-3-319-12114-7_4
pubmed.ncbi.nlm.nih.gov
Clapp, C., Thebault, S., Macotela, Y., Moreno-Carranza, B., Triebel, J., & Martinez de la Escalera, G. (2015). Regulation of blood vessels by prolactin and vasoinhibins. Adv Exp Med Biol, 846, 83-95. doi:10.1007/978-3-319-12114-7_4
Vasoinhibins: a family of N-terminal prolactin fragments that inhibit angiogenesis and vascular function - PubMed
Antiangiogenic molecules derived from prolactin (PRL) are not a single entity, but rather a family of peptides with different molecular masses, all containing the N-terminal region of PRL. Cleavage of PRL by cathepsin-D or by matrix metalloproteases generates N-terminal fragments that act on...
pubmed.ncbi.nlm.nih.gov