Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss
- Thread starter Ollie
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Who is able to translate the timelinie of HMI-115? It looks like they do Phase II/ Phase II in one round
Lots of companies do this, it just means the trial will probably have an extension set of phase 3 outcomes if the primary phase 2 outcomes measurements are met during the trial. Similarly a phase 1/2 trial will have phase 1 end points that are usually largely based on safety with some phase 2 end points of effectiveness.Who is able to translate the timelinie of HMI-115? It looks like they do Phase II/ Phase II in one round
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(online translation)Who is able to translate the timelinie of HMI-115? It looks like they do Phase II/ Phase II in one round
View attachment 160022
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thank you! what is the name of the program you use for image translation?
Look up 'image translation' on Google, you will probably find better ones than the one I used
The macaque study evidence is promising, undoubtely. But with human Androgenetic Alopecia fucked up stem cells (premature scenescence) play a big role. Its going to be a new powerful weapon, but to think this thing its going to reverse balding mmm.
PRL keeps hair follicle stem cells in a quiescent state, so hmmmm
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Retinoic acid modulates prolactin receptor expression and prolactin-induced STAT-5 activation in breast cancer cells in vitro - PubMed
Two recent papers demonstrate that prolactin plays an important role in the induction and progression of mammary tumours. Retinoids have been shown to be potent inhibitors of breast carcinogenesis. We studied expression of prolactin receptor mRNA in human breast cancer cell lines MCF-7, SKBR-3...
pubmed.ncbi.nlm.nih.gov
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Retinoic acid modulates prolactin receptor expression and prolactin-induced STAT-5 activation in breast cancer cells in vitro - PubMed
Two recent papers demonstrate that prolactin plays an important role in the induction and progression of mammary tumours. Retinoids have been shown to be potent inhibitors of breast carcinogenesis. We studied expression of prolactin receptor mRNA in human breast cancer cell lines MCF-7, SKBR-3...
what is your conlusion out of this article?
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He thinks that this disproves prolactin signalling inhibition being helpful for Androgenetic Alopecia because retinoic acid already does it and isn't very helpful.
Too bad that's not how any of this works.
It's not even a good attempt to dismiss HMI. He's just hoping no one will even read the study he posted, and it proves he's just trolling.
"no change in the stability of prolactin receptor mRNA was observed during 12 h of retinoic acid treatment"
"no change in the stability of prolactin receptor mRNA was observed during 12 h of retinoic acid treatment"
Pax1 and RUNX2 are possible downstream targets of prolactin. Antagonizing the PRLR downregulates Pax1 and upregulates RUNX2. There should be a good synergistic effect with Wnt agonists like KY19382 or VPA.
Pax1 and other Pax genes are strongly upregulated by prolactin. Pax1 is the gene with the greatest association with Androgenetic Alopecia after the androgen receptor. You can check your Androgenetic Alopecia risk on three of the Pax1 SNPs here. This is a tumor suppressor gene(anti-proliferative). It likely acts to shut down cell proliferation in the HF as if it were a tumor.
Primary SNP:
PAX1 rs2180439 [R, R]
PAX1 rs1160312 [R]
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
On the other side of the coin prolactin has been shown to downregulate RUNX2, a protein that is important for stem cell differentiation and has a synergistic relationship with Wnt signaling. The RUNX family of genes is also closely associated with A.G.A.
pubmed.ncbi.nlm.nih.gov
Pax1 and other Pax genes are strongly upregulated by prolactin. Pax1 is the gene with the greatest association with Androgenetic Alopecia after the androgen receptor. You can check your Androgenetic Alopecia risk on three of the Pax1 SNPs here. This is a tumor suppressor gene(anti-proliferative). It likely acts to shut down cell proliferation in the HF as if it were a tumor.
Primary SNP:
PAX1 rs2180439 [R, R]
- ‘C’ = Higher odds of male-pattern baldness, relative to ‘T’
- ‘T’ = Lower odds of male-pattern baldness, relative to ‘C’
PAX1 rs1160312 [R]
- ‘A’ = Higher odds of male-pattern baldness, relative to ‘G’
- ‘G’ = Lower odds of male-pattern baldness, relative to ‘A’
- ‘T’ = Higher odds of male-pattern baldness, relative to ‘C’
- ‘C’ = Lower odds of male-pattern baldness, relative to ‘T’
Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness - PMC
Androgenetic alopecia, known in men as male pattern baldness (male pattern baldness), is a very conspicuous condition that is particularly frequent among European men and thus contributes markedly to variation in physical appearance traits amongst Europeans. Recent ...
www.ncbi.nlm.nih.gov
Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population - PMC
Androgenetic alopecia (Androgenetic Alopecia) is a well-characterized type of progressive hair loss commonly seen in men, with different prevalences in different ethnic populations. It is generally considered to be a polygenic heritable trait. Several susceptibility ...
www.ncbi.nlm.nih.gov
On the other side of the coin prolactin has been shown to downregulate RUNX2, a protein that is important for stem cell differentiation and has a synergistic relationship with Wnt signaling. The RUNX family of genes is also closely associated with A.G.A.
Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats - PubMed
Hyperprolactinemia caused by physiological or pathological conditions, such as those occurring during lactation and prolactinoma, respectively, results in progressive osteopenia. The underlying mechanisms, however, are controversial. Prolactin (PRL) may directly attenuate the functions of...
pubmed.ncbi.nlm.nih.gov
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Pax1 and RUNX2 are possible downstream effectors of prolactin's regulation of hair growth. Antagonizing the PRLR downregulates Pax1 and upregulates RUNX2. There should be a good synergistic effect with Wnt agonists like KY19382 or VPA.
Pax1 and other Pax genes are strongly upregulated by prolactin. Pax1 is the gene with the greatest association with Androgenetic Alopecia after the androgen receptor. You can check your Androgenetic Alopecia risk on three of the Pax1 SNPs here. This is a tumor suppressor gene(anti-proliferative). It likely acts to shut down cell proliferation in the HF as if it were a tumor.
Primary SNP:
PAX1 rs2180439 [R, R]
Other Important SNPs:
- ‘C’ = Higher odds of male-pattern baldness, relative to ‘T’
- ‘T’ = Lower odds of male-pattern baldness, relative to ‘C’
PAX1 rs1160312 [R]
PAX1 rs6047844 [R]
- ‘A’ = Higher odds of male-pattern baldness, relative to ‘G’
- ‘G’ = Lower odds of male-pattern baldness, relative to ‘A’
- ‘T’ = Higher odds of male-pattern baldness, relative to ‘C’
- ‘C’ = Lower odds of male-pattern baldness, relative to ‘T’
Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness - PMC
Androgenetic alopecia, known in men as male pattern baldness (male pattern baldness), is a very conspicuous condition that is particularly frequent among European men and thus contributes markedly to variation in physical appearance traits amongst Europeans. Recent ...
Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population - PMC
Androgenetic alopecia (Androgenetic Alopecia) is a well-characterized type of progressive hair loss commonly seen in men, with different prevalences in different ethnic populations. It is generally considered to be a polygenic heritable trait. Several susceptibility ...
On the other side of the coin prolactin has been shown to downregulate RUNX2, a protein that is important for stem cell differentiation and has a synergistic relationship with Wnt signaling. The RUNX family of genes is also closely associated with A.G.A.
Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats - PubMed
Hyperprolactinemia caused by physiological or pathological conditions, such as those occurring during lactation and prolactinoma, respectively, results in progressive osteopenia. The underlying mechanisms, however, are controversial. Prolactin (PRL) may directly attenuate the functions of...
If we downregulate a tumor suppressing gene systemically, is that a concern?
I don't think so because BAY doesn't directly antagonize it, it only antagonizes one thing that is theoretically upregulating it in the hair follicle. It can still be activated by other processes. Also prolactin is normally proliferative and Pax1 is probably upregulated as a negative feedback regulator. Inhibiting prolactin is a treatment for brain tumors, prostate cancer, and best cancer. It would theoretically reduce your risk of cancer
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This image shows the expression of several hair growth genes in mesenchymal cells of RUNX2- mice. GLI1, FGFR2, TCF7, and Wnt10b are virtually eliminated when RUNX2 is downregulated.
pubmed.ncbi.nlm.nih.gov
Here is a review on prolactin's regulation of stem/progenitor cells, with a little bit about prolactin in the hair follicle.
www.ncbi.nlm.nih.gov
Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt and Pthlh signaling pathway gene expressions in suture mesenchymal cells - PubMed
Cleidocranial dysplasia (CCD, #119600), which is characterized by hypoplastic clavicles, open fontanelles, supernumerary teeth and a short stature, is caused by heterozygous mutations in RUNX2. However, it currently remains unclear why suture closure is severely impaired in CCD patients. The...
pubmed.ncbi.nlm.nih.gov
Here is a review on prolactin's regulation of stem/progenitor cells, with a little bit about prolactin in the hair follicle.
Minireview: Prolactin Regulation of Adult Stem Cells - PMC
Adult stem/progenitor cells are found in many tissues, where their primary role is to maintain homeostasis. Recent studies have evaluated the regulation of adult stem/progenitor cells by prolactin in various target tissues or cell types, including ...
www.ncbi.nlm.nih.gov
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If HMI restores things to normal (with regards to RUNX2) and is sufficient for regrowth (as with the monkeys), then maybe we should leave it at that and not push it past normal levels, because maybe like with wnt it can have bad effects. But I'm just speculating, I don't know that that's the case.
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I hadn't realized the antibody was administered with a non-local injection. Is there a reason to believe it couldn't be administered topically?