Why are all Androgenetic Alopecia medications delayed, or are they for most diseases?
Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss
- Thread starter Ollie
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I highlighted that part mosty because the newly promoted CEO verified (again) that HMI is the only big product in the pipeline. The fact that he didn't mention hair loss or other indications might not be good news, but at least he's balding so he has a vested interest.
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From the link from the previous page (https://translate.google.com/transl...s://mp.weixin.qq.com/s/QFuAKNzmkNRhVWY7xOYq3Q)
The second phase clinical trial in the United States is about to start, and the second phase clinical application in China has also been submitted, and the results are gratifying.
The second phase clinical trial in the United States is about to start, and the second phase clinical application in China has also been submitted, and the results are gratifying.
I would think there'd still be tons of men willing to pay big prices out of pocket for a cure or near-cure.
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I always thought they would Do the Trial in Germany.
Unfortunately in the Link above only United States Are mentioned...
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I thought this was expected no? Or were you expecting this to be a one and done treatment?
I don't see how one dose can last for years, unless they mean one course of treatment(i.e. 6 months).
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We've seen in various press releases they're referring to one course of 6 months, I'd say be charitable and assume this was lost in translation
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They have a partnership with PAREXEL to do clinical trials in Europe.
PAREXEL has Clinics in London and Berlin so they should Start Trial in Berlin as they Said they will do trials in Europe and Asia.
So why they only Start trials in US now ?!
PAREXEL has Clinics in London and Berlin so they should Start Trial in Berlin as they Said they will do trials in Europe and Asia.
So why they only Start trials in US now ?!
lostandfind
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I just found a Chinese wechat blogger wrote to Professor Xiao Ruiping through email and got a courtesy reply to his questions. Here's the link:
https://mp.weixin.qq.com/s/nJ97CFClMs1vB9DyaEZ-IQ
lostandfind
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Let me correct that part “and are currently being tested in the applicant's[volunteer's?] body”. The original Chinese means "the application for human experiment is underway".
Yes, but don't expect much. Zinc is beneficial, but many people have used it with little in the way of cosmetic results.
There is 0 profit in a hair loss treatment compared to larger ticket causes, despite what bald people will tell you.
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That's amazing.
The W/O means without? So this show that after 4 years without treatment there was regression but still most of the hair was kept. That's right?
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Yes that's what it means.
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I will note a couple things about this before people freak out. As highlighted above, estrogen receptor alpha is the one that promotes prolactin production. Estrogen receptor alpha is also shown to initiate the catagen phase. Estrogen grows hair because the predominant estrogen receptor in human hair follicles is beta. ERb silences the actions of ERa, so estrogen does not promote prolactin production in human scalp hair follicles.Although it's been documented that Zinc won't have any cosmetic results, if we take into account that our GH levels already naturally decrease as we age and that this downregulation may be locally exponentiated during hairloss, it could be a reasonable approach to implement in order to control extra pituitary prolactin (ePRL the one produced locally by hair and skin) activity.
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Leaving some of the studies and information I read today in case someone considers it useful.
"Regulation of extra pituitary prolactin
The 2 key hormones, estrogen and TRH, that control pPRL secretion also regulate ePRL and PRL-R expression in human scalp skin and hair follicles in vitro. Estrogen increases the expression of ePRL and PRL-R proteins in the epidermis, eccrine sweat glands and hair follicle ORS, corresponding to increased ePRL and PRL-R mRNA expression in ORS keratinocytes (87). The effect of TRH is more complex. In cultured human hair follicles, TRH increases ePRL mRNA and protein expression similar to estrogen. However, PRL-R expression at the protein level is decreased whereas PRL-R mRNA at the gene level is increased (87)... Recently, both PRL and its receptor have been located in inner root sheath and outer root sheath (ORS) keratinocytes of anagen and catagen hair follicles of mice".
Minireview: Extrapituitary Prolactin: An Update on the Distribution, Regulation, and Functions
Prolactin (PRL) is an important hormone with many diverse functions. Although it is predominantly produced by lactrotrophs of the pituitary there are a number of other organs, cells, and tissues in which PRL is expressed and secreted. The impact of this ...www.ncbi.nlm.nih.gov
"Oestrogen treatment significantly upregulated PRL and PRLR immunoreactivity in selected skin and hair follicle compartments, at the gene and protein level (P < 0.05). TRH significantly increased PRL immunoreactivity and transcription in hair follicles (P < 0.05); however, while it also increased PRLR transcription in hair follicles, it downregulated PRLR immunoreactivity in the hair follicle ORS"
Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro - PubMed
Our pilot study shows that two key endocrine controls of pituitary PRL secretion, oestrogen and TRH, also regulate PRL and PRLR expression in human skin. This provides novel insights into the regulation of extrapituitary PRL and PRLR expression, and invites exploration of oestrogen and TRH as...pubmed.ncbi.nlm.nih.gov
"Estradiol activates the hPrl promoter in extra pituitary sites such as skin and human hair follicles. This study, we show that E2 acts through ERα to activate the hPrl promoter through a degenerate estrogen response element (ERE) sequence found at −1189 bp relative to the transcription start site."
Human Prolactin Gene Promoter Regulation by Estrogen: Convergence with Tumor Necrosis Factor-α Signaling
Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced ...
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Impressive. Mr. Dog.Although it's been documented that Zinc won't have any cosmetic results, if we take into account that our GH levels already naturally decrease as we age and that this downregulation may be locally exponentiated during hairloss, it could be a reasonable approach to implement in order to control extra pituitary prolactin (ePRL the one produced locally by hair and skin) activity.
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Leaving some of the studies and information I read today in case someone considers it useful.
"Regulation of extra pituitary prolactin
The 2 key hormones, estrogen and TRH, that control pPRL secretion also regulate ePRL and PRL-R expression in human scalp skin and hair follicles in vitro. Estrogen increases the expression of ePRL and PRL-R proteins in the epidermis, eccrine sweat glands and hair follicle ORS, corresponding to increased ePRL and PRL-R mRNA expression in ORS keratinocytes (87). The effect of TRH is more complex. In cultured human hair follicles, TRH increases ePRL mRNA and protein expression similar to estrogen. However, PRL-R expression at the protein level is decreased whereas PRL-R mRNA at the gene level is increased (87)... Recently, both PRL and its receptor have been located in inner root sheath and outer root sheath (ORS) keratinocytes of anagen and catagen hair follicles of mice".
Minireview: Extrapituitary Prolactin: An Update on the Distribution, Regulation, and Functions
Prolactin (PRL) is an important hormone with many diverse functions. Although it is predominantly produced by lactrotrophs of the pituitary there are a number of other organs, cells, and tissues in which PRL is expressed and secreted. The impact of this ...
"Oestrogen treatment significantly upregulated PRL and PRLR immunoreactivity in selected skin and hair follicle compartments, at the gene and protein level (P < 0.05). TRH significantly increased PRL immunoreactivity and transcription in hair follicles (P < 0.05); however, while it also increased PRLR transcription in hair follicles, it downregulated PRLR immunoreactivity in the hair follicle ORS"
Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro - PubMed
Our pilot study shows that two key endocrine controls of pituitary PRL secretion, oestrogen and TRH, also regulate PRL and PRLR expression in human skin. This provides novel insights into the regulation of extrapituitary PRL and PRLR expression, and invites exploration of oestrogen and TRH as...
"Estradiol activates the hPrl promoter in extra pituitary sites such as skin and human hair follicles. This study, we show that E2 acts through ERα to activate the hPrl promoter through a degenerate estrogen response element (ERE) sequence found at −1189 bp relative to the transcription start site."
Human Prolactin Gene Promoter Regulation by Estrogen: Convergence with Tumor Necrosis Factor-α Signaling
Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced ...
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Here you Can Read about the partnership of Hope Medicine and PAREXEL in developping HMI-115 with clinical trials planned in Europe:
I Hope they will Start the clinical study in Berlin as soon as possible
I Hope they will Start the clinical study in Berlin as soon as possible
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maybe i'm totally out of context and no talking about the right type of oestrogen but if ERa are bad why does product like pantostin conaining 17a oestradiol are recommended for hairloss? https://pubmed.ncbi.nlm.nih.gov/7398983/ thanks