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It is Time to Start the Trial NOW !
Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss
- Thread starter Ollie
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me too haha xDI need some good hairloss news for my mental health
It is not big. But hairloss cure 2020 posted a new article yesterday
Honestly most of us should look forward more for SMI-1 ( Assuming it works in the same way in the long run ) to reach the grey market and be available reliably than this, as it will probably be extremely expensive.
Also any reason why we can't rub Cabergoline on our scalp? Is the mode of production of extrapituary prolactin different from regular PRL?
Also any reason why we can't rub Cabergoline on our scalp? Is the mode of production of extrapituary prolactin different from regular PRL?
There are different promoters for ePRL and it's not even understood yet what they all are. Dopamine only regulates pituitary prolactin.
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This has been answered a thousand times.
Per the BAY patent, competitive antagonists of the receptor are ineffective in the hair follicle because concentrations of prolactin are too high since it's produced within the hair follicle, and prolactin has a higher binding affinity for the receptor than the antagonists.
The BAY antibody is a non-competitive inhibitor, meaning that it doesn't have to outcompete prolactin for receptor binding. It can bind to the receptor along with prolactin and still silence it.
Therefore caber wouldn't work. I believe it's not sure yet whether SMI-1 will work on the long run.
But isn't SMI a competitive antagonist?
Also Cabergoline is a dopamine agonists, i've seen the talk about PRL produced in the hair follicle i was just wondering if the mechanism of production of extrap prl was also mediated by dopamine.
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It sure is.
Per the BAY patent:
"competitive PRLR antagonists are not effective in neutralizing local PRL signaling in the hair follicle due to their negative characteristics..."
It seems SMI does not feature these negative characteristics but again, I am not convinced it will work.
About caber, many people have used it in the past and it'd be known if it were working.
I know, my question was a way to ask about extrapituary prolactin specifity.
But going by testimonials and picture it seems to work, to a degree at the very least.
SMI is effective in neutralizing local PRL signaling in murine breast tissue at least
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Hey Pegasus, how are your gains? Can you share some feedback from discord group - how are others doing on SMI? Pics would be lovely.
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For now, nothing more conclusive than the pictures that were already shared on the Discord.
I think we will need to wait another 2-3 months at least to assess. Most likely even longer if you factor in the fact that people plan to substantially increase their daily intake once the second group buy is dispatched (ETA: 1 month).
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Wonder if we could contact her and ask about trials?
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That would be very nice! Are you able to contact her. I am from Germany and contacted several employes at Bayer Bit they Werent able to say anything
lostandfind
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Where did you find this?
lostandfind
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It‘s on the Wechat webpage of Peking University where professor Xiao Ruiping works.
Nice find. Is there anything else there? If I am seeing this right it does look these monkeys were basically cured in 6 months, and probably would be totally cured in a year. The trichoscope appears to show regression six months after treatment is discontinued, but no further regression until after the two year mark. By year 4 there appears to be more regression. The picture after 28 weeks of treatment appears to show a nearly full head of hair. If they kept on treatment long enough for it to grow out then they may well be fully cured. These pictures indicate to me that HMI-115 turns every tiny vellus hair into a thick, terminal hair. These pictures represent the best-case scenario anticipated from analyzing the data. This is phenomenal!
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This is seriously exciting. Great find, thanks!
Also, it's not just me but Hope Medicine's website has vanished for some time now?
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Bruh, I saw this picture without the caption and thought "well, that's one hell of an inflammated human scalp".
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That's a chad.