Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

[Joxy]

So, this product is near to cure for the most guys?

 

[Throwaway94]

A med related to prolactin receptors, but I am not sure what exactly. A group in Discord

Project PDRN

Lol you're confusing two very different things

 

[RolfLeeBuckler]

Wonder when they'll test this on the first human male. Imagine being that person, would feel so amazing tbh

imagine you will be able to participate as First human males and then you get the Placebo

 

[pegasus2]

Wonder when they'll test this on the first human male. Imagine being that person, would feel so amazing tbh

It's probably already happened, but no one knows yet.

 

[MaestroTR]

how do we know this is going to be sides-free for humans?

 

[John Difool]

how do we know this is going to be sides-free for humans?

The most popular question on this forum... Safety tests have been done already on humans.

 

[pegasus2]

3 months is proven safe in humans. It only takes 6 months for it to reverse hair loss to a very significant degree. How likely is it those extra 3 months will turn out to be unsafe? Almost zero when you consider it appears to be safe in non-human primates for 6 months.

 

[jan_miezda]

I’m gonna be nervous if hope medicine doesn’t begin phase 2 trial for Androgenetic Alopecia by 2022

 

[RolfLeeBuckler]

3 months is proven safe in humans. It only takes 6 months for it to reverse hair loss to a very significant degree. How likely is it those extra 3 months will turn out to be unsafe? Almost zero when you consider it appears to be safe in non-human primates for 6 months.

How likely is that after 3 months of treatment Maybe 1-2years later it will Show cancer or other side effects?

 

[pegasus2]

How likely is that after 3 months of treatment Maybe 1-2years later it will Show cancer or other side effects?

Considering the drug is being developed to treat cancer I'd say that's not likely.

 

[pegasus2]

@John Difool thought I'd answer your simple question here:View attachment 172853
View attachment 172869

Yes - a control group of monkeys would have been really helpful. It's not because the goal is to trick some animals

You get some monkeys, randomize them into treatment/no treatment groups, and blind the humans so the results aren't tainted by any bias on the part of the researchers. This is called single blinding

In this case, that would likely (but not necessarily) mean giving placebo injections to the control group monkeys (so the humans don't figure out which of them are on the real treatment). This makes it double blinded

The point of all this is to control for things like food, temperature, lighting, human interactions, prior living conditions, selection bias on the part of humans, etc. - the possible sources of bias here would be a gigantic list

Then at the end the study (which now has high internal validity) you'd be able to show a statistical cause-effect relationship by comparing the untreated monkeys to the treated ones, and also establish effect size. And then finally results can be generalized to humans (this is called external validity)

Do you feel smart now?

 

[RolfLeeBuckler]

Considering the drug is being developed to treat cancer I'd say that's not likely.

Thats good.
But @pegasus2 wasnt you the guy who Said months ago that For you this 3 months human Test wouldnt be enough? Would you participate in the Phase II trials or would it be to risky For you?

 

[pegasus2]

Thats good.
But @pegasus2 wasnt you the guy who Said months ago that For you this 3 months human Test wouldnt be enough? Would you participate in the Phase II trials or would it be to risky For you?

I would pay thousands of dollars to be in the trial.

 

[Jackshtbro]

Thats good.
But @pegasus2 wasnt you the guy who Said months ago that For you this 3 months human Test wouldnt be enough? Would you participate in the Phase II trials or would it be to risky For you?

He said it wouldn't be enough to determine efficacy I believe.

 

[surfer9]

phase 2 not officially started yet? or could it have, but they not mentioned it?

 

[pegasus2]

if the value of proper study controls can be openly mocked, then I view it as an opportunity to go over some of the basics of the scientific method

these exchanges matter more for 3rd parties reading them - I know I probably can't convince you of the importance of tools like peer review

the killer is that I think there's a decent chance HMI-115 works to some degree in humans, and maybe even works really well...
but that it's prudent to see if this works at least once in humans before cancelling my hair transplant procedure

I told you to stop quoting me. You say the same stuff over and over. I'm tired of this harassment every time I post. Perhaps I need to get the law involved

 

[Johnson40]

I told you to stop quoting me. You say the same stuff over and over. I'm tired of this harassment every time I post. Perhaps I need to get the law involved

Lmao, send a SWAT team this guy is being quoted on a hairloss forum

 

[pegasus2]

Lmao, send a SWAT team this guy is being quoted on a hairloss forum

Good idea. Get on that

 

[surfer9]

if the value of proper study controls can be openly mocked, then I view it as an opportunity to go over some of the basics of the scientific method

these exchanges matter more for 3rd parties reading them - I know I probably can't convince you of the importance of tools like peer review

the killer is that I think there's a decent chance HMI-115 works to some degree in humans, and maybe even works really well...
but that it's prudent to see if this works at least once in humans before cancelling my hair transplant procedure

If you only need 1 hair transplant procedure then I'd just get that done instead of cancelling and hoping on something else that maybe at best is coming in 2024.

But for me hair transplant is not an option. If it was I'd go get it done now.

 

[RolfLeeBuckler]

产业基地启航！北大分子医学南京转化研究院产业发展基地正式启用 - 园区要闻 - 南京生物医药谷 (njbpv.cn)

19-10-2021
HopeMedicine is an innovative biopharmaceutical company based on Professor Xiao Ruiping and his team from the School of Future Technology of Peking University, based on decades of research results in the field of translational medicine. At present, the company has completed the B round of financing, signed a global exclusive license agreement with Bayer for the development and industrialization of the monoclonal antibody HMI-115 targeting the prolactin receptor (PRLR), and is developing and industrializing multiple indications worldwide change. This antibody has the function of promoting hair growth and has a therapeutic effect on hair loss. It has shown excellent characteristics in animal models and human safety, and has obtained the approval of the US FDA Phase II clinical trial. In the near future, the US Phase II clinical trial will be launched. The patient was enrolled. In addition, Herqirui has also carried out the R&D and industrialization of more high-end innovative drugs through the dual-drive model of license-in (authorized introduction) and independent research and development.

--

SOOOO they will start Phase II clinical trial for HMI-115(hair growth) now in the US