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View attachment 178110
thats why i know
results Are Great hoping For less Side effects. No cancer, No Tumors No erectyle dysfunction
View attachment 178110
thats why i know
how it can cause ED? it should have opposite effectresults Are Great hoping For less Side effects. No cancer, No Tumors No erectyle dysfunction
It is still no human head. You can’t realise that experiments on animals in many cases translate very poor on humans. End results will tell us.View attachment 178110
thats why i know
why do people think results on a primate will translate to humans 1:1. sure it might do something maybe even positive but its not that likely that it'll be in the same categories as those stellar results in the monkeys
It is still no human head. You can’t realise that experiments on animals in many cases translate very poor on humans. End results will tell us.
Animal models are constructed to mimic conditions that would be found on a human. For mouse models, it's not very conducive to being replicated on humans because mice don't have androgen related hairloss, so they just study how quick the hair regrows or if it grows at all on a nude mouse.why do people think results on a primate will translate to humans 1:1. sure it might do something maybe even positive but its not that likely that it'll be in the same categories as those stellar results in the monkeys
how it can cause ED? it should have opposite effect
"Elevated PRL is associated with impairment of the hypothalamic-pituitary-gonadal axis.29 In the central nervous system, hyperprolactinemia inhibits centers that control sexual desire and erection"
Effect of prolactin on penile erection: a cross-sectional study
Although elevated prolactin levels have been shown to inhibit penile erection, the relationship between prolactin and erection of the penile tip or base has not been extensively researched. We therefore investigated the prolactin's effects on erection ...www.ncbi.nlm.nih.gov
So, if this drug translate good on human trials, so it should be ’cure’ for most of the guys?Animal models are constructed to mimic conditions that would be found on a human. For mouse models, it's not very conducive to being replicated on humans because mice don't have androgen related hairloss, so they just study how quick the hair regrows or if it grows at all on a nude mouse.
For stump-tailed macaques, they literally have androgen related hairloss. Most drugs you've heard of (finasteride, minoxodil, RU) were successful on the macaque model and pretty much translated 1:1 or better on humans (except for RU which no human data was published so we don't know). If you could find me a drug that worked on the model that didn't work in humans I'd love to see it (I dont think one exists), it's a very expensive animal model that is really only used when the researchers have high confidence.
no it will not effect circulating PRL levels . thats why this treatment will be so good. It only show really high specificity to the PRL receptor in hair follicle and some other tissues) to block its signaling. All new successful medicines have been biologics latelyso does HMI-115 lower the prolactin Level in Human?
So If you say so then HMI-115 won‘t do anything regarding ED or high Sex drive.no it will not effect circulating PRL levels . thats why this treatment will be so good. It only show really high specificity to the PRL receptor in hair follicle and some other tissues) to block its signaling. All new successful medicines have been biologics lately
I think it would raise it, if anything. It blocks binding to receptors to there would be more in the serum.so does HMI-115 lower the prolactin Level in Human?
sorry i dont understand that oneSo If you say so then HMI-115 won‘t do anything regarding ED or high Sex drive.
don’t get me wrong, i am
Happy If HMI-115 has No Side effects. But First you told it would give high potency and now you say that it don’t Effect circulating PRL Levels.
No offense!
So and If it raises the prolactin then what would that mean regarding sexual aspects?I think it would raise it, if anything. It blocks binding to receptors to there would be more in the serum.
Similar to how you get a slight rise in T by blocking 5ar to create DHT.
it would not raise it out of homeostatic range. It happen with all drugs when you antagonize a receptor you see a small increase in its endogenous ligand. We will know after phase 2 what kind of safety profile HMI have but i am really hopeful that its gonna be safeSo and If it raises the prolactin then what would that mean regarding sexual aspects?
A) erectyle dysfunction or B) higher Sex Drive/ better erections?
it seems like the major ones are GI , and headaches at the 60mg dose and fatigue at the 90mg dose. nothing really severe pops out here and this are pretty common to many more drug regimens out there. Plus they didn't really test it only many people. the sample size is less than 10 at each dosing interval. Its really well tolerated by the liver and kidney according to this
Can confirmit seems like the major ones are GI , and headaches at the 60mg dose and fatigue at the 90mg dose. nothing really severe pops out here and this are pretty common to many more drug regimens out there. Plus they didn't really test it only many people. the sample size is less than 10 at each dosing interval. Its really well tolerated by the liver and kidney according to this
any improvement hairwise ? thanksCan confirm