- Reaction score
- 2,102
yeWait did u manage to get enrolled?
yeWait did u manage to get enrolled?
is that based on the smi trial that was done by some members ?Can confirm
Man, did you get into the HMI trial?Chill guys, I just meant my analysis of the data confirms GI and headaches are the side effects we have to worry about. The trial hasn't started yet
No, they aren't enrolling yetMan, did you get into the HMI trial?
The fact that HMI doesn't affect PRL levels is irrelevant since it silences the receptors. What difference does it make how much PRL you have circulating in your blood if there's no effect when it binds to the receptor. If there's a downside to no PRLR activation, you're gonna get it with HMI regardless of how much PRL you have in your blood. That's my understanding of it, anyway, but I'm not an expert on the topic.
Where'd you get this from???
They only tested on 29 people in phase I???
Pretty standard phase 1 trial sample size. The pyralutamide p1 had like 12 people.The fact that HMI doesn't affect PRL levels is irrelevant since it silences the receptors. What difference does it make how much PRL you have circulating in your blood if there's no effect when it binds to the receptor. If there's a downside to no PRLR activation, you're gonna get it with HMI regardless of how much PRL you have in your blood. That's my understanding of it, anyway, but I'm not an expert on the topic.
Where'd you get this from???
They only tested on 29 people in phase I???
Where did you find the Bayer studies? Maybe they've been posted and discussed in the thread, but I missed it.i found it in the bayer studies „BAY 1158061“
Where did you find the Bayer studies? Maybe they've been posted and discussed in the thread, but I missed it.
Can we expect the trial to start by may end?No, they aren't enrolling yet
Thanks!Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women | Semantic Scholar
The PRLR antibody showed a favorable safety and tolerability profile in postmenopausal women with no distinct differences in occurrence of adverse events in BAY 1158061 or placebo-treated participants, considered a good candidate for further development in endometriosis or other PRL-mediated...www.semanticscholar.org
look For „Table 3“
Yes, there are certainly sex differences in sides for anything related to hormones. For example, prolactin is more important in bile production for men.Thanks!
So these are postmenopausal women, for whatever that's worth with regards to possible differences in sides between men and women.
Based on?Holy sh*t... I think HMI 115 might just be the cure dudes
Oh ya. I saw that. This sh*t is like super super super super super old news. I need to see human studies. The moment we see a human study on a man with the same success. We can all finally rest and drop our guns and live. .When
Look back a few pages, did you see the hair growth in the monkeys?
We can all finally rest and drop our guns and live. .