Im going to post from the 2006 EHRS society absracts and from other sources concerning tests on WHOLE HAIR FOLLICLES in test tubes and sustances that DIRECTLY AFFECT THEM>
Roxythromicin.
Caffeine.
RU58841
I'll also touch on Latanaprost and Minoxidil and Proanthocyandin B-3 and abscorbic acid (in Prox-N) and Jack Daniels whiskey (dont laugh....you'll see).
Roxythromycin is now in Clinical trials (I have a link) for Androgenetic Alopecia. It was tested in Human hair follicles, obtained from plastic surgery with informed consent, cultured for 6 days. Hair elongation was 1.96 mm's on average in the control group...........................................compared to 3.4 mm's in the Roxythromicyn group (it was only 3.32 mm's in the highest dosage Roxythromicyn group). This is all in vitro. ENTIRE HAIR FOLLICLES IN TEST TUBES.
11 men with Androgenetic Alopecia were given topical roxythromicyn (which is a topical immunosuppressant, anti-microbial, anti-fungal) and 4 showed great improvement, 4 slight improvement, 3 no change in 6 months time. Its now, again, in clinical trials. Its an attempt to interefere with T-cells in the immune response most likely, but it obviously positively effected hairs in test tubes. Source EHRS.
http://content.karger.com/ProdukteDB/pr ... =92842.pdf
Now, Caffeine...................some of this will come from Alpecin's site also as well as the EHRS. "Hair follicles from 14 biopsies, taken from vertex areas of male Androgenetic Alopecia patients, were cultivated fro 120-192 hours in the presence of normal William's E medium (control) or William's E medium containing different concentarions of testosterone and/or caffeine. Testosterone alone with the follicles suppressed growth . The WHOLE HAIR FOLLICLES have, of course, alpha five reductase enzymes in the outer root sheath.................so there was DHT made in those test tubes. Over a six to ten day period the Department of Dermatology and Allergology at the Fredrich-Shiller University in Jena, Germany and the University Hospital Schelswig-Holstein, University of Lubeck, Germany found that Testosterone alone inhibited growth, Caffeine alone stimulated growth, and that testosterone and caffeine together produced normal growth and EVEN SLIGHTLY above normal growth. All entire hairs in test tubes.
Tested in vivo over four months, the caffeine complex seen hair counts increase in Androgenetic Alopecia men, but I have not committed the specifics to memory.
RU58841. We all know this. Receptor blocker, Bryan posted on it. Whole follicles for two weeks. Beard hair denied testosterone slows growth, head hair denied testosterone grew much better. Head hair with just testosterone had growth slowed 23% in regards to keratinocyte activity and 12% polymerase DNA/RNA activity. WHOLE FOLLICLES
Copper peptides in South Korea................this was written:
Here is one study:
P38 THE EFFECTS ON HAIR GROWTH OF TRIPEPTIDE-COPPER COMPLEX L-ALANINE-L-HISTIDINE-L-LYSINE-CU2+(AHK-CU) IN CULTURED HUMAN OCCIPITAL DERMAL PAPILLA CELLS
Pyo HK, Yoo HG, Choi SJ, Won CH, Chung JH, Cho KH, Eun HC, Kim KH
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging & Hair Biology Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
INTRODUCTION: Tripeptide copper complex L-Alanyl-L-histidyl-L-lysine Cu2+ (AHK-Cu) is a growth factor for many kinds of cells. AHK-Cu is also known to increase growth factors such as VEGF and FGF, and to promote wound healing. OBJECTIVE: To evaluate the effect of tripeptide copper complex L-Alanyl-L-histidyl-L-lysine Cu2+ (AHK-Cu) on hair growth. METHODS: Cultured human dermal papilla cells (DPCs) were exposed to AHK-Cu (1 x 10-9 mol/L). The cytotoxicity and proliferation of cultured human DPCs were evaluated by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide). Annexin V-FITC staining was used for identifying apoptotic cells. We measured the expression of caspase-3, PARP (poly ADP-ribose polymerase), Bcl-2, and Bax by Western blot. We measured the length of the hair follicle in vitro organ culture. RESULTS: AHK-cu stimulated growth of DPCs. Apoptotic cells were decreased compared with control. The level of caspase-3 and PARP was decreased in AHK-cu treated group than serum-free control. In human hair follicle organ culture, the elongation of hair was increased over 155% in AHK-cu treated group. CONCLUSION: AHK-Cu seems to promote the survival of human DPCs by anti-apoptotic effects. Those results were confirmed by the decrease of the expression of caspase-3 and PARP, and by the increase of the ratio of Bcl-2/Bax. AHK-cu promotes the growth of human hair follicle and also has anti-apoptotic effects on the DPCs, which may play an important role in hair growth.
The study above didn't use whole follicles. HOWEVER, the peptides protected the hair cells from apoptosis, excited their growth RIGHT ALONG with what we would expect given to how well they did in phase 2 trials, where they achieved improved hair counts slightly better than minoxidil. The peptides tested were the alanine/histidine/lysine amino complex that is available in Tricomin and American Crew Revitalize.
http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract. The scientists studying it in Japan attribute its growth induction in hair to it being an analogue of prostaglandin F2alpha. They used another analogue of prostaglandin F2alpha, isorophyl unoprostone, and got stimulatory effects in the mice hair they tested it on in vivo. They ended in saying that the "stimulatory effects of PGF2 and PGE2 on hair growth have been discussed with regard to the role of protien kinase C and mast cells. This is what the scientists think about how this drug effects hair growth. It improved hair growth on macaques.
Minoxidil. Opens potassium channels, ups prostaglandin release, fights hardening of the connective tissue sheath that restricts dermal papilla enlargement that we see in male pattern baldness, ups VEGF.................very explainable.
Jack Daniels for hair?
quote:
Separation and identification of phytoestrogenic compounds isolated from bourbon.
Alcohol Alcohol Suppl. 1987; 1:551-5 (ISSN: 1358-6173)Rosenblum ER ; Van Thiel DH ; Campbell IM ; Eagon PK ; Gavaler JS
University of Pittsburgh School of Medicine, PA.
There is considerable evidence that several plant metabolites have estrogenic properties. Given that many alcoholic beverages are made from plants which have been shown to possess estrogenic activity, we considered the possibility that alcoholic beverages may contain estrogenically active substances. To evaluate this hypothesis we first extracted and then used gas chromatography/mass spectrometry to identify two phytoestrogens, biochanin A and beta-sitosterol in the bourbon extracts. Based on these findings we suggest that the feminization observed in chronic male alcoholics with liver disease may reflect, at least in part, the presence of biologically active phytoestrogens in the alcoholic beverages they consume.
PreMedline Identifier: 3426733
That was posted by Wookie on hair loss-R. Tom Hagerty mentioned a man that was admitted to a clinic in his hometown who drank a PINT of JD a day. He had very little body hair growth, b**ch-tits, 3+edema of his legs, testicular atropy, a phucked up liver.........................and probably a pretty damn good head of hair. Ive been interested in beta sis for a while because I think it mimics estrogen. Recently its been found out that stone/bronze/iron age Celts in Ireland used Pine oil as a hair gel. Pine oil has (BY VERY FAR) the highest amount of beta-sis of any known substance (about 18%). Avacoda oil only has .5% but is accredited with Mexicans having such a low incidence of prostate problems because they eat tons of the stuff. Rice bran oil (in American Crew Revitalize) has .75%. Its in sugar cane pulp (Garnier Fructis shampoo) and Soy also (.5%). I think it inhibits receptors or mimics estrogen in some fashion and yes, Im going to test it on my body hair to see what it does (currently a bit of avocado oil thats in garnier fructis hair gel, but going to buy some pine oil to really test it.................will let folks know in about six months. Its on the back of one hand---Im a fairly hairy guy).
Proanthocyanidins
http://www.ncbi.nlm.nih.gov/entrez/quer ... query_hl=7 That was used to show it sped up hair cell growth 140 percent in vitro (epilitheal cells) and induced anagen in vivo.
why is that important if it only is a hair cell test? because as a stimulant the results were exactly the opposite of what DHT and T does to hair cells and whole hair follicles in tests. It grew hair where male hormone has been shown to slow its growth or even kill it (apoptosis) in in vitro tests.
Now for my own experience with revivogen. I used revivogen on one wrist for 2 and a half months. Both my arms are fairly hairy (good density). I take propecia and drink green tea (which should inhibit type one DHT a tad). Revivogen has beta sis and saw palmetto and vitamin b6 (lessens receptor expression). The hair on the treated wrist grew very weakly compared to the untreated one. I was so convinced, I stopped my little test a bit earlier than I should have because I was persuaded that revivogen was a good anti-androgen. I have come to believe that since I was inhibiting DHT already to a great extent, that the beta-sis, and the .1-.4% of beta sis in the saw palmetto extract and the lessened receptor production induced by the vitamin b6 or pyrxidine (the correct and expensive form of it) is why it worked so well. It either must have mimicked estrogen or blocked the receptors to a great degree, because the hair growth on the treated wrist (despite the grape seed proanthocyandins therein) was really shitty. It must have lost androgenic stimulation of Testosterone also. I was convinced, anyway.
A HUGE amount of researchers would have to be dead wrong for Stephen to be right. Maybe they are, as Stenn and Costarialis are working for a company called FOLLICA now on a "novel" hair growth product at the cellular level. We, over at hairsite, have not been able to find out why they are either splitting time with Aderans or have left it completely. Aderans has STILL NOT ENTERED phase one HM tests. ICX is promising it will begin phase 2 shortly, but have been delayed all year. They are only going to test one measly f*****g centimeter of scalp. This is NOT inspiring confidence in those of us who have followed cloning.
One more additive.........................body hair to the scalp for the most part has seen the circumference of the body hair being so weak be a huge issue for men whove taken the plunge. Was reading a post the other day by a Doctor who does them, saying you need 2-4 body hairs on your head for 1 scalp hair moved to get the same hair mass in his experience. Its not enlarging to head hair width. A Korean Study over six years time demonstrated that head hair moved to the body will adjust its anagen phase to fit that of whatever recipeint site its placed on, BUT its VOLUME stays the same. Like that big fat black hair Colin Jahoda moved to Amanda Reynolds arm. It indicates that there is a genetic difference in head and body hair just like every single test on the subject has shown thusfar
