RecedingBoy
Established Member
- Reaction score
- 0
WHEN IS THIS PRODUCT COMING OUT?
I'M GONNA BE F'N MR. CLEAN BY THEN!
I'M GONNA BE F'N MR. CLEAN BY THEN!
Troymaclure
Established Member
- Reaction score
- 0
won't be long now
austin powers
New Member
- Reaction score
- 0
Waiting IMpatiently
Dutasteride has been approved already by the Swedish regulatory authority, and Sweden will be the reference member state for the EU for this drug.
What is the next step for release in the EU? Does this mean its release is iminent there? [Sorry, I am not at all familiar with the approval and regulatory process in Europe, so hopefully someone can enlighten me.]
As a US resident, I am waiting impatiently for the approval of the sNDA by the USFDA. I was perusing the FDA website for any indication of dutasteride being discussed at any upcoming meetings, but I could not find anything. I guess its release is still on track for possibly in October???
Dutasteride has been approved already by the Swedish regulatory authority, and Sweden will be the reference member state for the EU for this drug.
What is the next step for release in the EU? Does this mean its release is iminent there? [Sorry, I am not at all familiar with the approval and regulatory process in Europe, so hopefully someone can enlighten me.]
As a US resident, I am waiting impatiently for the approval of the sNDA by the USFDA. I was perusing the FDA website for any indication of dutasteride being discussed at any upcoming meetings, but I could not find anything. I guess its release is still on track for possibly in October???
Axon
Senior Member
- Reaction score
- 9
The advantages, as far as I know, are as follows:
1. Better inhibition of BOTH types of 5 Alpha Reductase, and therefore, inhibition of type 1 and type 2 DHT. Finasteride only inhibits type 2. Dutasteride inhibits up to 90% of both DHT types; Fina does something like 50-70% of type 2.
2. Potential for less than a daily dosage. There is a fairly well know example of a "beta" Dutasteride user from hairlosstalk.com - Dr. Monahan. He claims that in 6 months of usage he went from an advanced N4 to an N2. He also claims that Duta did indeed regrow his temples, but like Fina it was more effective on the vertex. After six months he dropped the drug, and was able to maintain this supposed regrowth with Fina and I think an occasional Minoxodil application.
3. According to Glaxo, users reported 150 more vellous hairs than fina users.
Not sure if they also used NANO shampoos like the Fina trial people did. Still, it sounds very, very promising...
1. Better inhibition of BOTH types of 5 Alpha Reductase, and therefore, inhibition of type 1 and type 2 DHT. Finasteride only inhibits type 2. Dutasteride inhibits up to 90% of both DHT types; Fina does something like 50-70% of type 2.
2. Potential for less than a daily dosage. There is a fairly well know example of a "beta" Dutasteride user from hairlosstalk.com - Dr. Monahan. He claims that in 6 months of usage he went from an advanced N4 to an N2. He also claims that Duta did indeed regrow his temples, but like Fina it was more effective on the vertex. After six months he dropped the drug, and was able to maintain this supposed regrowth with Fina and I think an occasional Minoxodil application.
3. According to Glaxo, users reported 150 more vellous hairs than fina users.
Not sure if they also used NANO shampoos like the Fina trial people did. Still, it sounds very, very promising...
RecedingBoy
Established Member
- Reaction score
- 0
finasteride trial ppl used Neutrogena T-Gel, not Nano.
i've heard from doctors though that anything that contains coal tar is not good for the scalp.
i've heard from doctors though that anything that contains coal tar is not good for the scalp.
G
Guest
Guest
Dr Lee is a big fan of combining TSAL and Nizoral.
I just started this routine about 2 weeks ago.
You can read about it on Dr. Lee's web site.
Brucelee
I just started this routine about 2 weeks ago.
You can read about it on Dr. Lee's web site.
Brucelee
Itchy
New Member
- Reaction score
- 0
Dutasteride Facts!
The maximum effect of daily doses of dutasteride on the reduction of DHT is dose dependent and is observed within 1 to 2 weeks. After 1 and 2 weeks of daily dosing with dutasteride @ 0.5 mg, median DHT serum concentrations were reduced by 85% and 90%, respectively.
In patients treated with 0.5 mg/day for one year, the median decrease in serum DHT was 94%.
The median increase in serum testosterone was 19% but remained within the normal physiologic range.
Following the administration of a single 0.5 mg soft gel capsule, time to peak serum concentrations (Tmax) of dutasteride occurs within 2 to 3 hours.
The terminal elimination half life of dutasteride is approximately 5 weeks at a steady state. Due to the long half-life of dutasteride, serum concentrations remain detectable for up to 4 to 6 months after discontinuation of treatment.
Dutasteride pharmacoknetics have not been investigated in subjects less then 18 years of age.
Over 90% of the dutasteride study population was Caucasion.
The maximum effect of daily doses of dutasteride on the reduction of DHT is dose dependent and is observed within 1 to 2 weeks. After 1 and 2 weeks of daily dosing with dutasteride @ 0.5 mg, median DHT serum concentrations were reduced by 85% and 90%, respectively.
In patients treated with 0.5 mg/day for one year, the median decrease in serum DHT was 94%.
The median increase in serum testosterone was 19% but remained within the normal physiologic range.
Following the administration of a single 0.5 mg soft gel capsule, time to peak serum concentrations (Tmax) of dutasteride occurs within 2 to 3 hours.
The terminal elimination half life of dutasteride is approximately 5 weeks at a steady state. Due to the long half-life of dutasteride, serum concentrations remain detectable for up to 4 to 6 months after discontinuation of treatment.
Dutasteride pharmacoknetics have not been investigated in subjects less then 18 years of age.
Over 90% of the dutasteride study population was Caucasion.
09-25-2002
Dutasteride will be available as AVOLVE on 12/16 in Switzerland and 12/23 in Sweden. This is the latest information from GSK Europe. We are prepared to offer a liposomal topical version as soon as the product is released.
09-24-2002
http://WWW.LIPOXIDIL.COM
Dutasteride will be available as AVOLVE on 12/16 in Switzerland and 12/23 in Sweden. This is the latest information from GSK Europe. We are prepared to offer a liposomal topical version as soon as the product is released.
09-24-2002
http://WWW.LIPOXIDIL.COM
Rudiratlos
Member
- Reaction score
- 0
so do u guys think toppical Dusat.. wil be the solution...
i hope it will coz i would really like a toppical solution (not an oral one) coz
although the dust.. will come in your blood stream ..the concentration will probably be a lot lower (so less site effects?)
i hope it will coz i would really like a toppical solution (not an oral one) coz
although the dust.. will come in your blood stream ..the concentration will probably be a lot lower (so less site effects?)
Gizmo
Established Member
- Reaction score
- 3
willstar,
What I heard of it is what I heard about every topical besides minoxidil and spironolactone:
It works, but that the results are non-visual and the little results it give wares of after a short period of time.
As far as I know, well.... have you ever come across:"there are endless lotions and positions to regrow your hair."?
I think this is one of those.
I think they take advantage of the desperation of hair loss sufferers.
Like 97% of the hair loss industry.
By the way I just checked today...I’ve been taking Propecia for 11 months now (I thought it was less), and I’m getting no results.
Keep thinning.
My hair looks disgusting.
What I heard of it is what I heard about every topical besides minoxidil and spironolactone:
It works, but that the results are non-visual and the little results it give wares of after a short period of time.
As far as I know, well.... have you ever come across:"there are endless lotions and positions to regrow your hair."?
I think this is one of those.
I think they take advantage of the desperation of hair loss sufferers.
Like 97% of the hair loss industry.
By the way I just checked today...I’ve been taking Propecia for 11 months now (I thought it was less), and I’m getting no results.
Keep thinning.
My hair looks disgusting.
Rudiratlos
Member
- Reaction score
- 0
im sorry i meant toppical dusteride...its not on the market i guess ,,,.. but i know Merkx (i believe) is doing a trail studie with topical finasteride..
if that works probably topical duasteride will work even better.!
??
if that works probably topical duasteride will work even better.!
??
Rudiratlos
Member
- Reaction score
- 0
we will know in 2 to 5 years!! i think .. a least the effect will be scientifficly proven in a double blind study!
G
Guest
Guest
Agreed. Volume seems way down.
Where are Rocky and Troy Maclure?
Brucelee
Where are Rocky and Troy Maclure?
Brucelee