I’ve read this study and it’s pretty interesting. However many of this is predicting what may happen based on aging and trying to correlate time periods of getting BPH and neurological diseases. Of course I’ve also made my statement why at this point in time rat studies are pretty useless in terms of correlating severity of side effects to human when taking finasteride.Interesting new study:
Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role - Current Sexual Health Reports
Purpose of Review Here, we summarize current knowledge of androgens’ action gained over the recent years. Recent Findings Neurosteroids are produced in the brain and peripheral nerves, independent of endocrine glands have been investigated for how they are regulated, and have actions via...link.springer.com
Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role
Recent Findings
Neurosteroids are produced in the brain and peripheral nerves, independent of endocrine glands have been investigated for how they are regulated, and have actions via non-steroid receptor targets to mediate social, affective, and cognitive behavior and to protect the brain. Androgens’ organizing actions in the peri-natal period have effects throughout the lifetime that may be recapitulated later in life during critical periods and at times of challenge. Developmental changes in androgens occur during mid-childhood, adrenarche, puberty, adolescence, young adulthood, middle age, and andropause. Changes in androgens with a 5α-reductase inhibitor, such as finasteride, result in disruptions in organizational and activational functions of androgens that can be unremitting.
Summary
Normal developmental or perturbation in androgens through other means can cause changes in androgen-sensitive phenotypes throughout the lifespan, in part through actions of neurosteroids.
Again we break down as we age and we actually know testosterone and androgenic compounds in general are not good for long term health in high doses. Again though it’s a balancing act. Many guys on trt may only live till 65-75 but live a more “virile lifestyle” compared to the healthy individuals who doesn't try to supplement test, will live longer but not have youthful characteristics and lifestyle.
A huge reason topical testosterone is typically not suggest is actually due to greater rates of CVD mainly because of testosterone being to much converted to DHT and which at high quantity’s be harmful to many body parts.
Again simple studies need to be done. Take individuals, put them on finasteride, over the span of 5-10 years compare to placebo and measure the cognitive testing scores as well as overall well-being. I think when people try and get to a*** about digging deep into any drug or supplements you can come up with 100 of theories, predictions and correlations.
Anyways everyone who hasn’t please read the article, had lots of good info on the basic spectrum of neurosteriods and androgens.
good night