Gadgetine

Exploring The Hormonal Route. Hair=life.

Adri23

Adri23

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dar3k said:
Hi, maybe some of you guys remember me… So I decided to give a try to HRT to save/reverse my hairloss. Unfortunately NOTHING works on me.

I have been on 50mg bicalutamide ed + 4 mg estradiol + 10mg oral minoxidil ed + 0.5mg dutasteride ed + 1mg finasteride ed + 150mg RU58841 + 20mg Pyrilutamide (2 x 10mg) + Topical minoxidil 2 x day + Rosemary Oil ed

My blood test after 1 month on HRT:
T: 1.5nmol/l
E2: 239 pg/ml
DHT: 39pg/ml

After 3 months:
T: 0.9nmol/l
E2: 289pg/ml
DHT: 26pg/ml

After 6 months:
T: 0.6nmol/l
E2: 233pg/ml
DHT: undetectable

I also did a blood test for thyroid tsh, ft3, ft4, ferritin, iron, b12, prolactin and everything was fine.


It slowed down a bit my hair loss but after 8 months my hairs are thinner. My crown is much thinner, still receeding, temple peaks literally disapeared, my hairs are still miniaturizing.

All I want to say to you guys, HRT - even with proper female levels, even with undetectable DHT values is not guarantee to hairloss. As you can see for example on Reddit /femalehairloss a lot of women with normal female hormone levels are going bald too. They have diffuse thinning/female pattern baldness/receeding hairlines etc.

If you want to try HRT/pyrilutamide/RU etc. of course you can do it, but remember that there is no GUARANTEE to stop/reverse hairloss.
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f*****g hell I feel so identify with this guy. He went through hell with this curse just like I am now.... Poor guy... I wonder if he is still alive cause this sh*t can really consume you when you've tried everything and you keep thinning...
 
Ryuzaki hedeki

Ryuzaki hedeki

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Adri23 said:
You guys are really lucky tbh. It's easy to forget you are really lucky when you manage to recover your hair(despite the treatment) I hope you never goes through the agony of balding even using the most effective hair loss treatment, I do and it is the worst mental torture I've ever had, the fact that you can control the hair miniaturization is incredible frustrating and depressing. I only remember one guy here that kept balding despite using everything, he was @dar3k
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You deserve a full head of hair. You are the most sane person here after me
 
Ryuzaki hedeki

Ryuzaki hedeki

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Adri23 said:
f*****g hell I feel so identify with this guy. He went through hell with this curse just like I am now.... Poor guy... I wonder if he is still alive cause this sh*t can really consume you when you've tried everything and you keep thinning...
Click to expand...
He is the norwood repear himself:(
 
Adri23

Adri23

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Ryuzaki hedeki said:
You deserve a full head of hair. You are the most sane person here after me
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Thanks mate... Unfortunately for me there is no luck... Idk if I will be able to beat this with more mg of dutasteride but it seems like I won't. Hope your hair is going good
 
Adri23

Adri23

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And the thing that keep torturing me is not only the fact that I'm balding which is very bad itself, but that I managed to improve my hair during 2023, then on march my DHT increased x4 and months later my hair is so thin and fried just like it was pre HRT
 
Adri23

Adri23

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The difference of @dar3k and me is that he had undetectable DHT while in my case my DHT increased. I think I still have a tiny chance to solve it somehow, he unfortunately had none
 
Adri23

Adri23

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I think at the point of their life they are using this as entertainment so there's nothing other to do than troll here. Out of all the ppl active here I think im the only one balding, so they just use this as distraction. I don't think this thread is beneficial for me right now since I have so much distress with this curse, I don't even remember why I came back in the first place, guess it is just a matter of trying to escape the reality I've been forced to live
 
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Almas_NW0

Almas_NW0

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Adri23 said:
f*****g hell I feel so identify with this guy. He went through hell with this curse just like I am now.... Poor guy... I wonder if he is still alive cause this sh*t can really consume you when you've tried everything and you keep thinning...
Click to expand...
Yes, it's terrible. I have to appreciate what I have. I assume that the injections are more effective than the pills. I don't remember what form of estradiol he took. But I also remember a man who went bald on injections. I wish I had a better understanding of what that is and whether there is anything I can do about it... It's completely counterintuitive.
 
Adri23

Adri23

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Almas_NW0 said:
Yes, it's terrible. I have to appreciate what I have. I assume that the injections are more effective than the pills. I don't remember what form of estradiol he took. But I also remember a man who went bald on injections. I wish I had a better understanding of what that is and whether there is anything I can do about it... It's completely counterintuitive.
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Trust me it's just hell. Whenever you touch your hair, try to style, shower or look in the mirror is absolute pain. The most depressing stuff is that at the time you are watching the inevitable, you remind yourself you have nothing else to do, it is the end, I have reached the limit nothing will help anymore. I remember when I was depressed because dutas and oral minoxidil stopped to work, but I got really motivated when at least I still have something to try. Even on cpa and sublingual pills and gel my hair was not so good but still didn't lose the hopes since I still had injections which gives you higher and more stable e2 levels levels so there was still room of improvements, but now after using everything every f*****g thing that can help Androgenetic Alopecia im miniaturizing so f*****g fast is unbelievable. I only hope my theory makes sense and recover hair on the next months. Also need to get my stomach fixed because having uncontrolled Androgenetic Alopecia + shedding from not eating enough is definitely suicide.
 
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Almas_NW0

Almas_NW0

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Adri23 said:
Trust me it's just hell. Whenever you touch your hair, try to style, shower or look in the mirror is absolute pain. The most depressing stuff is that at the time you are watching the inevitable, you remind yourself you have nothing else to do, it is the end, I have reached the limit nothing will help anymore. I remember when I was depressed because dutas and oral minoxidil stopped to work, but I got really motivated when at least I still have something to try. Even on cpa and sublingual pills and gel my hair was not so good but still didn't lose the hopes since I still had injections which gives you higher and more stable e2 levels levels so there was still room of improvements, but now after using everything every f*****g thing that can help Androgenetic Alopecia im miniaturizing so f*****g fast is unbelievable. I only hope my theory makes sense and recover hair on the next months. Also need to get my stomach fixed because having uncontrolled Androgenetic Alopecia + shedding from not eating enough is definitely suicide.
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Nutrition is overrated. I hope you can find a way to improve the situation by eliminating the root of the hormonal problem.
In theory, E should desensitize the AR and make the remaining androgen levels too low to cause baldness. Androgenetic alopecia is common in women, but it is easier to treat. I have never seen a young girl with serious baldness.
 
Adri23

Adri23

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Almas_NW0 said:
Nutrition is overrated. I hope you can find a way to improve the situation by eliminating the root of the hormonal problem.
In theory, E should desensitize the AR and make the remaining androgen levels too low to cause baldness. Androgenetic alopecia is common in women, but it is easier to treat. I have never seen a young girl with serious baldness.
Click to expand...
Yeah but DHT is so powerful it can still strongly cause you lot of androgen issues if not under a threshold. I think cis women has better chances at recovering their hair and less aggressive balding not only because e2 but men also have stronger AR expression overall, even with e2 they response to DHT is usually stronger. Also for some reason men tend to upregulate androgens(specially DHT) more than women. Also some men like me(i did a genetic test) have more active 5ar enzyme than the rest which means if I ovesupress T my DHT tends to increase by other pathways. Also my DHT last blood test is 21 ng/dl which is no joke at all. DHT is a paracrine hormone so blood serum only shows a small fraction of what is made on tissues, so imagine from 5 ng/dl dht to 21 ng/dl dht on serum, how much could my dht increase specifically on the scalp? A lot more than serum.

I still don't understand why you laugh about my theory. It actually makes sense on science's eyes. I have a genetic test, many blood test(6 specifically) with all the hormones you can imagine(except oxo androgens), and a change in some hormones that can potentially lead to creation of DHT(which in my case they got converted because my DHT is. x4 more than december). Also the timing was perfect(the controversial bica increase). I know it is not happening to you, nor 414 nor exwhyyou but remember that every body is different and maybe your 5ar enzyme (specially 5ar1 which converts backdoor pathways androgens to DHT) is not as overactive as mine is that's why the rest of you don't have the upregulation
 
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losingbattle88

losingbattle88

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Adri23 said:
Yeah but DHT is so powerful it can still strongly cause you lot of androgen issues if not under a threshold. I think cis women has better chances at recovering their hair and less aggressive balding not only because e2 but men also have stronger AR expression overall, even with e2 they response to DHT is usually stronger. Also for some reason men tend to upregulate androgens(specially DHT) more than women. Also some men like me(i did a genetic test) have more active 5ar enzyme than the rest which means if I ovesupress T my DHT tends to increase by other pathways. Also my DHT last blood test is 21 ng/dl which is no joke at all. DHT is a paracrine hormone so blood serum only shows a small fraction of what is made on tissues, so imagine from 5 ng/dl dht to 21 ng/dl dht on serum, how much could my dht increase specifically on the scalp? A lot more than serum.

I still don't understand why you laugh about my theory. It actually makes sense on science's eyes. I have a genetic test, many blood test(6 specifically) with all the hormones you can imagine(except oxo androgens), and a change in some hormones that can potentially lead to creation of DHT(which in my case they got converted because my DHT is. x4 more than december). Also the timing was perfect(the controversial bica increase). I know it is not happening to you, nor 414 nor exwhyyou but remember that every body is different and maybe your 5ar enzyme (specially 5ar1 which converts backdoor pathways androgens to DHT) is not as overactive as mine is that's why the rest of you don't have the upregulation
Click to expand...
My god just let your body be. U basically torture your body. I decided to throw ALL hairloss products in the bin. And im never turning back.
 
losingbattle88

losingbattle88

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Adri23 said:
Trust me it's just hell. Whenever you touch your hair, try to style, shower or look in the mirror is absolute pain. The most depressing stuff is that at the time you are watching the inevitable, you remind yourself you have nothing else to do, it is the end, I have reached the limit nothing will help anymore. I remember when I was depressed because dutas and oral minoxidil stopped to work, but I got really motivated when at least I still have something to try. Even on cpa and sublingual pills and gel my hair was not so good but still didn't lose the hopes since I still had injections which gives you higher and more stable e2 levels levels so there was still room of improvements, but now after using everything every f*****g thing that can help Androgenetic Alopecia im miniaturizing so f*****g fast is unbelievable. I only hope my theory makes sense and recover hair on the next months. Also need to get my stomach fixed because having uncontrolled Androgenetic Alopecia + shedding from not eating enough is definitely suicide.
Click to expand...
LOL dutas and oral min never ever worked on me. Hair got worse wayy faster without even shedding at all. Im a different breed. This is also why I decided to give up on treatments entirely. Hey at LEAST it worked for you.
 
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