Exploring The Hormonal Route. Hair=life.

[Mr. Grey]

Guys, dexametazone is useful? It is real gave result with 2 time a week applications? If yes, how many mg it should be consist, 1, 4?

 

[DHTcel]

Gonna make a separate post/thread about this. (PSA) Prostate Specific Antigen is the marker for prostate growth and prostate growth is stimulated via androgenic activity in the tissue. The lower Androgenic activity=less damage for hair. This is order from strongest AA to weakest.

 

[bridgeburn]

Gonna make a separate post/thread about this. (PSA) Prostate Specific Antigen is the marker for prostate growth and prostate growth is stimulated via androgenic activity in the tissue. The lower Androgenic activity=less damage for hair. This is order from strongest AA to weakest.

This is fantastic

 

[DHTcel]

This is fantastic

https://www.hairlosstalk.com/interact/threads/list-of-strongest-to-weakest-antiandrogens.123173/
here Is the thread

 

[DHTcel]

Bicalutamide is stronger than any other anti-androgen. It completely shuts the receptors.

Correct. "Although the affinity of bicalutamide for the AR is approximately 30 to 100 times lower than that of DHT (IC50 ≈ 3.8 nM),[37][13][1][38] the main endogenousligand of the receptor in the prostate gland, sufficiently high relative concentrations of bicalutamide (1,000- to 10,000-fold excess) are able to completely prevent activation of the AR by androgens like DHT and testosterone and subsequent upregulation of the transcription of androgen-responsive genes and associated effects.[39][20][40][41] At steady-state, relative to the normal adult male range for testosterone levels (300–1,000 ng/dL),[42]circulating concentrations of bicalutamide at 50 mg/day are roughly 600 to 2,500 times higher and at 150 mg/day around 1,500 to 8,000 times higher than circulating testosterone levels" 100mg Bicalutamide is enough to prevent AR activation completely, hence why more people with prostate cancer survive on bicalutamide in comparison to those who are on CAB: Combined Androgen Blockage (Castration +Gnrh agonist)

 

[Father_of_Shiseido]

Correct. "Although the affinity of bicalutamide for the AR is approximately 30 to 100 times lower than that of DHT (IC50 ≈ 3.8 nM),[37][13][1][38] the main endogenousligand of the receptor in the prostate gland, sufficiently high relative concentrations of bicalutamide (1,000- to 10,000-fold excess) are able to completely prevent activation of the AR by androgens like DHT and testosterone and subsequent upregulation of the transcription of androgen-responsive genes and associated effects.[39][20][40][41] At steady-state, relative to the normal adult male range for testosterone levels (300–1,000 ng/dL),[42]circulating concentrations of bicalutamide at 50 mg/day are roughly 600 to 2,500 times higher and at 150 mg/day around 1,500 to 8,000 times higher than circulating testosterone levels" 100mg Bicalutamide is enough to prevent AR activation completely, hence why more people with prostate cancer survive on bicalutamide in comparison to those who are on CAB: Combined Androgen Blockage (Castration +Gnrh agonist)

Can someone post the link to ein’s thread?

 

[DHTcel]

Can someone post the link to ein’s thread?

https://www.hairlosstalk.com/intera...-initial-shedding-from-anti-androgens.111183/ here

 

[Capone]

Kinda scared to start. Don’t want shrinkage or deeper wrinkles.

 

[Ikarus]

Kinda scared to start. Don’t want shrinkage or deeper wrinkles.

Looks like you have joined the dark side!

 

[Capone]

Looks like you have joined the dark side!

Lol don’t know about the dark side but I will use the smallest of pea amounts, along with minoxidil and dermapen. Here’s hoping. Botox sess next weekend. We only get one shot at this life. Do whatever makes you happy.

 

[I'mme]

Looks like you have joined the dark side!

She's a female, right?

 

[Ikarus]

Lol don’t know about the dark side but I will use the smallest of pea amounts, along with minoxidil and dermapen. Here’s hoping. Botox sess next weekend. We only get one shot at this life. Do whatever makes you happy.

You should use bicalutamide. In all honesty, there’s such a false stigma behind it but people don’t even bother considering the use of it, even at low doses...

 

[DHTcel]

She's a female, right?

hahahaha

 

[Ikarus]

She's a female, right?

A fe(male) now

 

[Capone]

Nope

You should use bicalutamide. In all honesty, there’s such a false stigma behind it but people don’t even bother considering the use of it, even at low doses...

what about Bica as a topical?

 

[Obsessive]

Nope

what about Bica as a topical?

Best of luck with the e-gel. Give it a shot. Although the last 6 months have had ups and downs, all in all estrogel has not delivered the results I had hoped for. Probably bc I'm not using oral AA in combo.

 

[Marky]

Kinda scared to start. Don’t want shrinkage or deeper wrinkles.

wrinkles from E?

 

[Ikarus]

Nope

what about Bica as a topical?

I wouldn't bother using it topically, since it still ends up systematic...

 

[DHTcel]

1 - I agree, never said otherwise.
2 - I took Dutasteride alongside Bicalutamide/Cyproterone/Lupron and it was useless.

I really don't get why you're saying all of this to me, I never asked you to explain - especially badly. I know what I'm dealing with, and I don't think you know a lot about endocrine system.

And don't forget, you're not a specialist, doctors, so don't tell people "you should take". Because you don't really know what they should take.
And what we are taking shouldn't be recommended ... especially when we don't really know the long term real issues.

I could be wrong, but you probably didn't stay on bicalutamide for long enough (1-2 years to see results). A lady who was balding on 50mg cpa + ethinyl estradiol, and finasteride, but she stopped balding with flutamide 250mg and regrew 21% of her hair.

see study: https://www.fertstert.org/article/S0015-0282(02)04551-X/fulltext

she was a cpa/finasteride non responder like yourself, "Flutamide resulted in a reduction of 21% in Ludwig scores (2.3 ± 0.2 to 1.8 ± 0.1). The other treatment effects were not statistically significant."

the conclusion of the study was that "Flutamide at a dose of 250 mg daily induced a modest improvement in alopecia after 1 year, whereas cyproterone acetate and finasteride were not effective. Treatment for more than 1 year may be required for better results."

this tells us that treatment with AR blockers like flutamine/bicalutamide may take up to 1-2 years to show results.

remember(750mg flutamide=50mg bicalutamide) so 250mg flutamide=16mg bicalutamide and you said you were using up to 200mg bicalutamide. Thats more than 10x the relative dose she was using. Again I could be wrong but Im just trying to give some hope

 

[DHTcel]

See, when using any medication remember, YMMV. This goes for OCPs, SSRIs, 5-AR inhibitors, Accutane - you name it. For example, I can't tolerate TRUVADA very well, and although not a listed side-effect of the drug - the high acidity I experienced on it caused me to shed quite a bit.

Spironolactone most often doesn't lower hormone levels at standard doses, and in any case, that is not the primary anti-androgenic mechanism of the drug. Spironolactone attaches itself to androgen receptors, thus blocking the effects of male hormones. The fact that it is steroidal should signal to the HPA that less testosterone production is needed, but that was not how it worked for me at all, and I was on 300mg for 4 months. Mind you, I broke out on 300mg and not on 100mg. Bizarre, right?

If I were you, I would give Finasteride more time and evaluate your success - it is much slower than Bicalutamide or CPA for sure, but it can be very effective and its feminization is negligible. As evidenced on this thread - your follicles will grow back on the right medication for you, but as you are young and only recently experienced Androgenetic Alopecia you are likely to find decent regrowth as your follicles cannot miniaturize that fast. My best regrowth on Flutamide came through in Fall 2013 and I had started in Jan 2012. It only improved thereafter, although reducing the dose would precipitate massive synchronized sheds and breakouts so I stayed on until Jan 2018. Don't internalize bromides on the internet about hair loss. eg: diffuse responds better to drugs; DUPA is incurable; finasteride is a scam; younger persons with Androgenetic Alopecia are likely to go bald faster - NO. Diffuse just means your genetic pattern is different - I never had temple recession until I went off Flutamide and that's not the pattern my dad has either; DUPA, if caused by Androgenetic Alopecia, will respond to anti-androgens; finasteride works wonders for many; and your genetic sensitivity is also a continuum with ups and downs - some men recede a bit and freeze there for decades. Androgenetic Alopecia is better identified as a component of androgenization than aging.

I think the biggest mistake I made was not understanding Androgenetic Alopecia and treatment when I was 20, and experienced my first synchronized shed on my crown - after discontinuing finasteride - and accepted Flutamide therapy from my doctors without questioning them. I was so terrified that those hairs were indeed lost that I was keen to do anything to control it. If you're losing hair, remember, you can always regrow it on the right support.
My dad actually experienced a bit of regrowth on Nutrafol (wtf?!) - and here I am more than half his age having popped all kinds of heavier medications. At the end of the day, no one cares about your hair as much as you do, and in my case absolutely no one remembered that I had a bald patch at 20 when my hair regrew x 9999 at 22 on Flutamide ; )

You're on top of it and things will work out for you! Only because I would have advised myself the following at your age (and I in no way mean to be disparaging or dismissive of your awareness and understanding of your own body and needs) - be strategic and deploy the AAs in the order they are needed.

xx KSA

what dose of flutamide did u use, how long did it take to see results, what were sides, how much regrowth, pls tell me, thanks.