Thanks for responding. As I mentioned before, that partial agonist effect of SAAs is troubling with my mind, but now that I reassess, I kinda understood that the partial agonist effect it’s like binding to the AR receptor and “deactivate” it in some extent BUT not fully like NSAAs, for example Bicalutamide. I am asking this because I am kinda worried if AR upregulation could happen from this agonist activity, and If somehow the things are going to get worse. But as I said I think it’s not the case and probably the partial agonist working like that: not fully binding to the AR , but this that left behind maybe still do harm or not like the success stories showed (only way to know is if you try/experiment). I haven’t tried CPA yet , I am just trying to understand how it will affect the things if I start it. I agree about Spironolactone. Thank you.You are not bothering anyone; this is the point of the site to discuss hormonal medications and their effects on baldness/regrowth. Those are pretty high-level questions you are asking and the answer may indeed lie in prostate cancer research. It also helps in a practical way if you mention your current regime because others might have tried something similar. Is there some aspect of the CPA experience that perturbs you?
I have only tried spironolactone, primarily at 200 mg and I can't recommend it but others do report good results. spironolactone's side effects are immediate/short-term while bica and CPA mostly have longer-term side effects which likely makes spironolactone the safest for long-term use.
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