@tato123 So what is your pov for the treatment we elaborated together in the last few weeks? (finasteride,bica,metf.,resveratrol,etc.)
?
What do you think, how long can we stay on it, and what would you say about efficacy, how long are you personally on these drugs?
First of all I would like to say that this is nuclear. I will always repeat this in all posts. Some may just read this post.
I think at the moment with my knowledge I confess somewhat limited but hardworking, I would say that
50mg bicalutamide + 5 air blocker + metformin 500mg -1000mg
is the maximum treatment today, it would only be necessary to change the dose of bicalutamide to make it stronger if necessary.
But I believe that this formula will solve almost everything if it is androgenic alopecia and if you don’t want to use a complete MTF treatment, maybe in this scheme I fit some E2 cycles to decrease TOTAL Testosterone, little, for a short time, 4 weeks 8 weeks, as a bodybuilnd cycle, I think it would be less toxic to the testis
Some considerations
Bicalutamide will act by increasing endogenous levels of T and clearly everything as a result via enzymatic conversion (example: ESTRADIOL, DHT) and as already discussed and discussed it has proved to be the most "safe" AA compared to its analogs (FLUT, ENZA) , Bicalutamide does not cross the blood-brain barrier, patients do not have seizures which is a potential side effect of their analogs, preserves bone density, sexual function, spermatogenesis, hepatoxically light up to 50mg and the best is an AR receptor blocker and effective in that, but it will block practically 100% of its AR receptors, say that bicalutamide has only a peripheral effect so it preserves bone density and muscle mass, and there are others that say it preserves because of the increase in E2 so it is not clear to know.
The truth is that the AR receptor blocker in men is not all good, so it is one of my fears with it, along with hyperandrogenicity and positive regulation of the AR receptor.
is other thing is GYNECOMASTIA the chance you have is great, in general 50mg will be about 52% of patients according to the laboratory study with 370 volunteers
Here comes the second point
The 5th blocker would block the increase in DHT caused by the T outbreak caused by bicalutamide
Theorizing according to the articles, metformin would help in the regulation of AR receptors, and in "defective" cells it would cause apoptosis.
And not only that does bicalutamide inhibit the PAR-2 receptor as well, and messing with it can cause cancer and others .
The AMPK pathway prevents cancer and inflammatory disease by inhibiting the NK pathway (iflamation process)
This is the CIS nuclear bomb, now if you want to go to hydrogen bomb just add oral minoxidil
But this is the extreme, you can try a lot before I even made other posts about it.
But this is the only extreme treatment that function will maintain, some ejaculation volume, better erections, preserved fertility, in other words, in general it is still a "male" treatment
In addition I think that only GNrh inhibitors and full MTF treatments.
They are all drugs that need a long time to give results, so consider for a lifetime, maybe someday if you have solid results stable for a long time, you can change the dosages to change, but between knowing it is for a long time.
I think this is the summary of everything at the end
www.nature.com
