Exploring The Hormonal Route. Hair=life.

[Almas]

@Almas Please don't worry much, this has not to mean everything for EVERYONE. As Ein said, your genetics have to be completely fucked up for Finasteride + Bicalutamide not to work.

I know. However, I am not insured not to end up in the same situation. Especially considering that even my mother is going bald. Plus, I'm just upset by the fact that we can't cure everyone. I wanted to help all people overcome this, but in some cases we are powerless. Life is full of sh*t, sometimes it's hard to put up with

 

[Pls_NW-1]

I know. However, I am not insured not to end up in the same situation. Especially considering that even my mother is going bald. Plus, I'm just upset by the fact that we can't cure everyone. I wanted to help all people overcome this, but in some cases we are powerless. Life is full of sh*t, sometimes it's hard to put up with

Pray for stem cell research to have a breakthrough, and that we'll get treatment in 10-15 years. We can do so much with blockers and exogenous hormones, battling against genetics is sometimes really hard. But actually USING your genetics is a step forward (such as multiplication).

 

[Almas]

Pray for stem cell research to have a breakthrough, and that we'll get treatment in 10-15 years. We can do so much with blockers and exogenous hormones, battling against genetics is sometimes really hard. But actually USING your genetics is a step forward (such as multiplication).

In 15 years I will come to terms with baldness, and my youth will be behind me. I need hair right now. The prices will be huge

 

[JaneyElizabeth]

I guess you could say I've given up (for now) and have gone the hair system route. I'm still taking estrogen, finasteride and progesterone for a multitude of reasone, but I'm sick of my hairline affecting my confidence. It sucks that not even HRT has worked for me, and I'd love to have my own natural hair but after over a year of this still sub par results I caved.

I would copy one of @bridgeburn's protocols because you know that it worked for at least someone. It doesn't make much sense for HRT to work so well for some of us and for others to be getting no results to speak of.

 

[JaneyElizabeth]

Even at 75mg bica, with my T in the undetectable range I continued to go bald.

Estrogen matters for regrowth but I don't think that T levels being low are enough on their own for regrowth. I continue to believe that non-responders to HRT are not using enough estrogen and oral minoxidil likely works in unison with estrogen to regrow hair.

 

[Norwoody]

Is there a drug out there that is basically the opposite of an aromatase inhibitor?

 

[Almas]

Estrogen matters for regrowth but I don't think that T levels being low are enough on their own for regrowth. I continue to believe that non-responders to HRT are not using enough estrogen and oral minoxidil likely works in unison with estrogen to regrow hair.

It should at least stop ...

 

[JaneyElizabeth]

It should at least stop ...

One would think. Franz's situation puzzles me. A lot of the non-success stories don't make a lot of sense unless we are missing say, some genetic pre-disposition to hair restoration with estrogen which perhaps would have to do with aromatase and T conversion. But it's not just the hair counts as I think most of us thoroughly agree now, that matters. It is rather overall attractiveness and for many us, the ability to grow our hair long.

I feel as though anyone following my protocol or either of the @bridgeburn protocols would be successful but what we are doing is still rare and we just don't have that much participation still except for MtF's and MtF's often wear wigs and take years for hair improvement and these are years that many/most XY's don't have to wait although as mentioned, we would think hairloss would stop as per eunuchs throughout history upon chemical castration. I am still really interested in these different aspects.

One issue that comes up is whether it is either impossible or extremely difficult to regrow hair in the temples. I think that it is doable but that like with children, this is one of the last areas to respond and fill in at around the ages of say six to eight. It's hard to see why HRT could restore hair everywhere else but not in the temples but it might be that the hair stressors on this area are extra hard to overcome.

 

[JaneyElizabeth]

Not saying that I am an expert in chemistry but I sure never thought in 11th grade that I would be using knowledge of molecular weight and structure to assist in battling hair loss. Many of us have learned a fair amount about prostate cancer and different types of RI expression and the prostate/hair connection is difficult because it is clearly related and yet prostate cancer and hair loss do not appear to be especially correlated strongly.

 

[JaneyElizabeth]

It makes no sense to increase the dosage of Bicalutamide if it is castrated. I do not even know what to say. I don't understand how this is possible ... I want to die

You still only have a few months in and you aren't using oral min so you have to be patient. I tend to view estradiol as essential. DHT destroys and estrogen repairs. Just getting rid of T, without estrogen at least anecdotally, isn't enough once follicles go dormant. I still feel that to a large extent we don't really understand how receptor blocking AA's really work to promote feminization. It seems to spoof higher estrogen but why do we need to do that instead of just using more E2?

So in this sense, I don't think that we know if AA's do anything different from estradiol in terms of helping against hair loss and to promote recovery.

 

[Almas]

One would think. Franz's situation puzzles me. A lot of the non-success stories don't make a lot of sense unless we are missing say, some genetic pre-disposition to hair restoration with estrogen which perhaps would have to do with aromatase and T conversion. But it's not just the hair counts as I think most of us thoroughly agree now, that matters. It is rather overall attractiveness and for many us, the ability to grow our hair long.

I feel as though anyone following my protocol or either of the @bridgeburn protocols would be successful but what we are doing is still rare and we just don't have that much participation still except for MtF's and MtF's often wear wigs and take years for hair improvement and these are years that many/most XY's don't have to wait although as mentioned, we would think hairloss would stop as per eunuchs throughout history upon chemical castration. I am still really interested in these different aspects.

One issue that comes up is whether it is either impossible or extremely difficult to regrow hair in the temples. I think that it is doable but that like with children, this is one of the last areas to respond and fill in at around the ages of say six to eight. It's hard to see why HRT could restore hair everywhere else but not in the temples but it might be that the hair stressors on this area are extra hard to overcome.

I think that the frontal region has the worst blood flow, and it is hardest to increase aromatase in this area even at high levels of E. This part of the scalp is primarily subject to fibrosis, so treatment should be started while the follicles are still producing hair. My follicles are alive, I have tiny hairs, this is encouraging

 

[Almas]

You still only have a few months in and you aren't using oral min so you have to be patient. I tend to view estradiol as essential. DHT destroys and estrogen repairs. Just getting rid of T, without estrogen at least anecdotally, isn't enough once follicles go dormant. I still feel that to a large extent we don't really understand how receptor blocking AA's really work to promote feminization. It seems to spoof higher estrogen but why do we need to do that instead of just using more E2?

So in this sense, I don't think that we know if AA's do anything different from estradiol in terms of helping against hair loss and to promote recovery.

I want to find a way to stop the progression. Because I'm not capable of growing my hair if I'm not even capable of stopping this sh*t. Moreover, I do not want to sit on HRT for life. Bicalutamide is my hope. It should be equivalent to castration, but as I learned yesterday, even castration does not always stop the Androgenetic Alopecia.

 

[JaneyElizabeth]

I think that the frontal region has the worst blood flow, and it is hardest to increase aromatase in this area even at high levels of E. This part of the scalp is primarily subject to fibrosis, so treatment should be started while the follicles are still producing hair. My follicles are alive, I have tiny hairs, this is encouraging

I have been massaging my temples and especially forehead and pushing them gently forward a great deal to loosen them up in case that matters. It might be that males have larger foreheads and slightly larger head sizes and that could have adverse effects on blood flow. One thing that I challenge is the idea that hair in fringe areas is not susceptible to DHT. I think that it is but it is just the flip side of the temples in terms of the scalp being less tight in such areas.

 

[JaneyElizabeth]

I want to find a way to stop the progression. Because I'm not capable of growing my hair if I'm not even capable of stopping this sh*t. Moreover, I do not want to sit on HRT for life. Bicalutamide is my hope. It should be equivalent to castration, but as I learned yesterday, even castration does not always stop the Androgenetic Alopecia.

HRT for life could mean as little as two estradiol pills per day and certainly 4mg SL should get levels up and not being that big of a life stressor. It won't work for you otherwise because you are compulsive about your hair and you will always be waiting for the next shoe to fall as they say.

 

[Almas]

HRT for life could mean as little as two estradiol pills per day and certainly 4mg SL should get levels up and not being that big of a life stressor. It won't work for you otherwise because you are compulsive about your hair and you will always be waiting for the next shoe to fall as they say.

Usually, if Bicalutamide does not help you, estrogen does not help you either. First you need to find a way to stop baldness, and Estrogen is a growth stimulant that will not work if the problem with androgens is not solved. So I really hope I answer Bicalutamide like Maave / DHTcel

 

[Almas]

Plus, it will feminize me, change my face, make me physically weaker, etc.

 

[JaneyElizabeth]

Trying to do some research on P4 and hair regrowth and I get hit after hit saying that what we are trying to do is impossible, including this from a transplant clinic. Garbage in, garbage out:

With transgender hair transplants, another factor in the equation can be male pattern hair loss. Male-to-female transgender clients who begin transitioning at a young age are less likely to experience this type of hair loss, due to the early intervention of hormone therapy. However, if balding has begun at the time of transition, hair restoration treatment will be necessary. Estrogen therapy may prevent further loss, but cannot restore hair that has already been lost.

Transgender Hair Transplants – Becoming Your True Self, Beautifully - Tempus Hair

The journey to becoming one’s true self is filled with challenges when that journey involves transitioning from the gender assigned at birth to one’s authentic identity

hairdoctorflorida.com

 

[JaneyElizabeth]

Usually, if Bicalutamide does not help you, estrogen does not help you either. First you need to find a way to stop baldness, and Estrogen is a growth stimulant that will not work if the problem with androgens is not solved. So I really hope I answer Bicalutamide like Maave / DHTcel

I don't think you can provide data to indicate that and we know, more or less unless we are grossly all wrong, that estrogen regrows hair--with the AA's, we are less sure. Part of the problem is that no one defines what "regrowth" means. Greatly increasing anagen might be the same as "regrowth" or it could differ in terms of dormant follicles being very difficult to wake up. I have not seen any recountings of prostate cancer hair regrowth so we don't know even what the pervasiveness of any such regrowth was.

 

[JaneyElizabeth]

We believe that the mechanism responsible for achieving scalp hair regrowth in transgender women is the suppression of testosterone to normal female levels. In our experience, this usually requires therapy with both spironolactone and estradiol. However, if transgender women treated with estrogen alone can achieve testosterone at normal female levels, we would expect to see scalp hair regrowth in these patients as well. Furthermore, it would be interesting to determine whether more scalp hair regrowth occurs over time as this patient continues hormone therapy.

Scalp Hair Regrowth in Hormone-Treated Transgender Woman - PMC

Evidence of androgenetic alopecia, or male pattern baldness, can be distressing for transgender women. Here we present the case of a transgender woman with scalp hair regrowth after ∼6 months on oral estradiol and spironolactone therapy achieving ...

www.ncbi.nlm.nih.gov

 

[Almas]

I don't think you can provide data to indicate that and we know, more or less unless we are grossly all wrong, that estrogen regrows hair--with the AA's, we are less sure. Part of the problem is that no one defines what "regrowth" means. Greatly increasing anagen might be the same as "regrowth" or it could differ in terms of dormant follicles being very difficult to wake up. I have not seen any recountings of prostate cancer hair regrowth so we don't know even what the pervasiveness of any such regrowth was.

Yes, these are just my assumptions. There is very little information regarding Bicalutamide for the treatment of baldness, we know practically nothing. I assumed that this is guaranteed to stop further baldness 100%, but in practice this is not always the case.