Exploring The Hormonal Route. Hair=life.

[JaneyElizabeth]

No. But it was his last post on here. And it was long ago. @Itsnoahkennedy might know more than anyone else on here.

I think that he might be able to be contacted via Reddit. Someone gave me his screen name there and it was Bridgeburn.

 

[JaneyElizabeth]

Some have accused me of not being persistent enough. But in fact, if you continue to go bald during treatment, it means that the scheme does not work. After 1,2,3,4 and 5 months on Bicalutamide I saw a deterioration, so there was no doubt that it was not helping me. Now I am on HRT and I will be evaluating the first results in 3 months.

There is a myth that you need to give treatment for at least half a year in order to conclude whether it helps. Sometimes these periods are extended to a year or two, which is even more absurd when we have to rush to treatment. In fact, more often than not, three months are enough. You should have had an improvement in hair quality and an increase in hair diameter before new ones began to grow.

It took me six years to regrow most of my hair and that can be typical for many people apparently but age might have an effect but then again, I am no spring chicken, officially anyway.

There's no doubt that MtF's have an advantage here compared to guys using HRT for hair in that we can proceed without worrying about breast growth or excessive feminization.

 

[JaneyElizabeth]

I've already posted several pictures of myself here, from every possible angle.
I even posted my blood tests, you have no idea what you're talking about, I've been posting things here for almost 1 year; I come here to expose information for free for people like you to challenge what I say, this is impolite.

I've posted pictures of myself here more than 3 times, you can check, don't be lazy.
Sorry, I won't post pictures of myself every time, because one or another user didn't see.


I'm sorry.

Believe if you want.

Talk is cheap, do something, i do, and u?

Wow. I think that it is pretty well established that HRT can regrow a full head of hair in the best cases but we don't know exactly why hair restoration comes so easy for many and so hard for most.

 

[JaneyElizabeth]

I think Noah's success in part may be due to the fact that he used Minoxidil (before starting HRT), which prevented permanent follicular death and scalp fibrosis. I even thought about oral minoxidil, but I am annoyed by its deceptive nature: it will grow your hair, but when you stop it, it will quickly disappear. There is an option to use it all the time, but I don't know ... I'll try to do just hormones

Pretty much all treatments are ineffective without either dutasteride or estrogen, when you go off them. I have so many treatments but oral min to me, seems far more effective than using it topically, which didn't do anything but maintenance for me.

 

[JaneyElizabeth]

First out, first in is not at all how I would characterize my regrowth. It seems to improve hair everywhere not just on top or in the corners. One thing is that if successful, many people will notice an ovalization of the hairline which seems to sort of roll forward gradually.For MtF's having such a canopy hairline improves passability as does having a lower hairline.

I thought so too, but no. Hair is smaller in diameter and miniaturized. Basically, if I answer HRT, the first improvement should occur in these areas, because they started to go bald last.
View attachment 164018

 

[JaneyElizabeth]

Your pattern is like mine. You answered HRT, that's encouraging. Typically, no one shows their hair from the back and side when sharing progress. I have not found any success stories of retrograde alopecia on HRT
Is your hair better now than in this photo? I hope HRT has improved the sides

Retrograde hair loss to me, seems to be related to thinning but rarely full hair loss. As mine has come in, the fringe and sides look much better. I also microneedle my entire scalp and face once a week which probably helps.

 

[JaneyElizabeth]

Where to buy oral minoxidil if Im from Russia? Some Indian online markets? Cant find any with international shipping

Drink topical.

 

[JaneyElizabeth]

How is this different from what you are doing? I just chose a cheaper and more convenient option. But we'd both be on HRT, man
I have no ulterior motives. I am afraid of body changes. I'm just a very desperate guy who decided to go for it so as not to kill myself. nw0 or die

I mean, it doesn't really matter whether one has subconscious desire for feminization upon going on HRT. Some people think that HRT causes dysphoria but that's a stretch in my view. People should consider their life and family goals and many seem to think marriage won't be an option without hair. I still worry about breast growth and facial feminization making me male fail. I have to wear a lot of jackets to hide my incipient breast growth which might put off the females that interest me. My face seems more and more androgynous especially as my hair grows and very few males over the age of 30, say, can grow their hair to my length without it looking like a rat's nest. HRT improves the "quality" of every single hair shaft in terms of shine, texture and manageability.

Regards,

Janey

 

[JaneyElizabeth]

If you did that, with the aromatase change, it might make things worse hair-wise, I would think. The second thing is that only rarely does conjecture offer us a new way or approach that hasn't already been tried. I would advise you to read some of the non-binary posts related to Serms on Reddit as they pop up because we still don't know all of the parameters.

@ChemHead

 

[JaneyElizabeth]

yeah mate here’s a little list of things I can remember from the top of my head, no blood work ever done mate. While on high dosages of loniten I kept an eye on my blood pressure.

Loniten 5-10mg - no side effects.
Loniten side effects at 30-40mg.. irregular heart beats, low energy, weak.. excessive nose bleeds, puffy eyes apon waking up in the morning, sore heads

Avodart - first 6months - 1yr - no sex drive (none). Extended sheds.

bic - small gyno, sore to touch, lower sex drive, sore heads, rashs/pimples.

Mate, I have used oral min (drinking topical) at 12.5mg twice daily and along with weight gain and water retention and puffy eyes but I will taper down to 6.25mg and then get a feel for whether that hurts anything. I doubt it will for someone on HRT or using dutasteride/finasteride. You have a dream protocol so to speak and since it is oral, you don't have the ingestion issues that others have. I do think that a full recovery is possible just from HRT but why wait if oral min can get us there more quickly. The puffy eyes improve during the course of the day but they make me look strange when I first wake up. I use moisturizers and concealer but hopefully at only 12.5mg daily divided into two doses will resolve my eye issues. People can also try filler in the eye area although I haven't done that yet but in general, filler is amazing and costs an amazing amount of money.

 

[JaneyElizabeth]

Very good find, although I am not completely sure how to interpret these results (or actually I am, I think the results are incomplete the way they are presented here). Of course, we have the binding affinities on the left, indicating good selectivity of WAY-2000070 for ER-beta. On the right, we have the transactivation of the receptor, however, it is not specified to what extent the receptors are activated. For example, the compound 7-alpha-hydroxy-DHEA (7-HD) only has an EC50 of 20 uM, but is able to activate ER-beta with 60-70% potency of E2*. So, we see that the EC50 for transactivation of WAY-2000070 for ER-beta is 31nM, but it does not specify the transcriptional activity of the receptor at that concentration. This is a really important difference, since you might end up with a compound that can only activate a small part of ER-beta associated genes.

As a side note, the more I read about estrogens and their relation to hair growth, the more I am starting to doubt E2's real global efficacy (and the more I realise estrogens are very poorly understood, with many pathways other than ligand-binding that influence tissue genetic expression). In my previous post I mentioned that E2 lengthens anagen in frontotemporal male follicles (FMF), but induces catagen in the same female follicles (FFF)**. The authors of the associated paper conclude that E2 may have vastly different local effects depending on the scalp region. To complicate things even further, E2 is also known to strongly decrease AR density***, which may or may not account for some if not all of its positive effects on FMFs. If we were to replace E2 with a selective ER-beta ligand, we might not get any positive effects or maybe even induce catagen, like in the FFFs. To me, it is not clear enough whether ER-beta truly is the holy grail for hair growth. There has been only one study to my knowledge on these positive effects, and that one was executed on mice****. Since male and female human follicles already behave differently, these results are absolutely not transferable to human (male) follicles.

Personally, I think that E2 can definitely be useful. However, based on the current knowledge it should preferably be used locally, only on the frontotemporal region (for males, that is). Whether the positive effects are coming from direct estrogen-related gene transcription or AR supression is still unknown, unfortunately (at least to me). Also, anyone wanting to experiment with E2 (or any hormone for that matter) should be aware of all its direct and downstream effects, some of which are especially detrimental to males. Of course I am always open for discussion on this topic, as we can all learn from each other.

Source list (again, no hyperlinks, still restricted on my account):

*Estrogen Receptor b Ligands: Recent Advances and Biomedical Applications
**Estrogens and the hair follicle
***The hair follicle as estrogen target and source (really nice, complete article with tons of information)
****Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling

​

I am pretty certain that HRT can restore a head of hair but since I have multiple treatments, I am not much of a data point and here I am referring to microneedling which can at times, it appears, vastly improve a person's hair and in some cases, produce spectacular growth. I use generally 2.0mg and 2.5 mg needles. Since Bridge didn't microneedle, he is a better source.

I use finasteride and duta together and never a single side but no regrowth either but these are more so maintenance drugs. Like me, Bridge added oral minoxidil later in the game but he had already had substantial success by then and that's how my situation with oral min is. I absolutely think that it helps and is probably, after HRT and perhaps microneedling, the number one treatment for hair growth.

I have looked at those articles, at least a couple of them and eh, I just didn't find any of it convincing. There's a one person study from 2016 involving an MtF who was almost bald then regrowing her hair substantially just from E2 and spironolactone. I think that a lot of XY's want to believe that HRT won't work for hair, subconsciously, so that they don't have to try it since "it's not guaranteed to work". People have difference life preferences. One type of person that I find exceedingly ridiculous are the MtF's who think that using HRT only for hair is some sort of sacrilege by infringing on their territory.

 

[JaneyElizabeth]

I've already posted several pictures of myself here, from every possible angle.
I even posted my blood tests, you have no idea what you're talking about, I've been posting things here for almost 1 year; I come here to expose information for free for people like you to challenge what I say, this is impolite.

I've posted pictures of myself here more than 3 times, you can check, don't be lazy.
Sorry, I won't post pictures of myself every time, because one or another user didn't see.


I'm sorry.

Believe if you want.

Talk is cheap, do something, i do, and u?

Just look earlier in this thread at Bridge's pics. Are those pics fake? How about the hundreds of pics that I have posted going back six years? I mean, life is too short for people to "spoof" hair regrowth for what purpose now? It's a lot of work doing this and most people feel too exposed to post pics which I completely understand. I have posted pics of every single body part and obviously hair and face so that people can see what they might be getting into. It's also an enormous amount of work to find the right cocktail and that took me well over 7 years before I noticed substantial regrowth. At times, (like today), I have meticulously used estrogel as a hair tonic, meaning all over the scalp regardless whether an area is balding or not and I apply it several times daily, especially on the hair line. Microneedling is painful and I don't usually enjoy it but two years now have I microneedled once weekly without fail.

I had a shed to complete baldness but I don't think that was my baseline so I am not a story of a cueball with dormant follicles that have woken up but still from bald to beautiful, so to speak, is impressive and my baseline had lots of corner recession and an incipient bald spot that was quite noticeable under bad lighting.

 

[JaneyElizabeth]

I wonder how deep their voice is

Now, now. Always look at the adam's apple and you can always do like the French and "tais-toi et soit belle".

 

[JaneyElizabeth]

“no offence your nipples say otherwise”

how is gyno a gym related side effect?

the people on this section of the forum are getting worse haha.

This is now a banter thread that has little to nothing to do with the first 400 pages or so when Bridge was contributing. There have always been naysayers but when you check, quite often, they have gone off on their own tangent and then complain that HRT didn't work for them. Except for microneedling and maybe oral min in some cases, HRT is the only thing that will restore a full head of hair and not just that, a head of hair that is "rock and roll" hair that looks good long, like maybe Roger Waters and Mick Jagger.

 

[Rysteve93]

Mate, I have used oral min (drinking topical) at 12.5mg twice daily and along with weight gain and water retention and puffy eyes but I will taper down to 6.25mg and then get a feel for whether that hurts anything. I doubt it will for someone on HRT or using dutasteride/finasteride. You have a dream protocol so to speak and since it is oral, you don't have the ingestion issues that others have. I do think that a full recovery is possible just from HRT but why wait if oral min can get us there more quickly. The puffy eyes improve during the course of the day but they make me look strange when I first wake up. I use moisturizers and concealer but hopefully at only 12.5mg daily divided into two doses will resolve my eye issues. People can also try filler in the eye area although I haven't done that yet but in general, filler is amazing and costs an amazing amount of money.

The puffy eyes are a b**ch lol.

 

[michel sapin]

i don't know how you achieve to handle the hypertrichosis side effect which might be insane with 5 mg dosage... Or i might be extra sensitive fo this particular side. Taht suks because i had no side effect from the oral except this one.

 

[JaneyElizabeth]

i don't know how you achieve to handle the hypertrichosis side effect which might be insane with 5 mg dosage... Or i might be extra sensitive fo this particular side. Taht suks because i had no side effect from the oral except this one.

Laser removal except for the beard area, is pretty reasonable and if the question is hair or no hair, I don't have any bodily issue since most or almost all of such issues can be managed alternately but hair you pretty much still have to grow it yourself so you could titrate downwards but you might be facing something entirely difference if you are talking about bear-like body hair growth and then, that does trump hair loss. I had a buddy with an incredible head of hair but he literally had hair every single centimeter and thick too.

 

[Experimentality]

I am pretty certain that HRT can restore a head of hair but since I have multiple treatments, I am not much of a data point and here I am referring to microneedling which can at times, it appears, vastly improve a person's hair and in some cases, produce spectacular growth. I use generally 2.0mg and 2.5 mg needles. Since Bridge didn't microneedle, he is a better source.

I use finasteride and duta together and never a single side but no regrowth either but these are more so maintenance drugs. Like me, Bridge added oral minoxidil later in the game but he had already had substantial success by then and that's how my situation with oral min is. I absolutely think that it helps and is probably, after HRT and perhaps microneedling, the number one treatment for hair growth.

I have looked at those articles, at least a couple of them and eh, I just didn't find any of it convincing. There's a one person study from 2016 involving an MtF who was almost bald then regrowing her hair substantially just from E2 and spironolactone. I think that a lot of XY's want to believe that HRT won't work for hair, subconsciously, so that they don't have to try it since "it's not guaranteed to work". People have difference life preferences. One type of person that I find exceedingly ridiculous are the MtF's who think that using HRT only for hair is some sort of sacrilege by infringing on their territory.

I absolutely agree. HRT can definitely regrow hair everywhere on the head as proven countless times. However, we do not know the exact mechanism behind it - is it due to actual transcriptional activity at the ER or just AR suppression? Studies actually point to the latter, hence I am more and more leaning towards AR suppression, which E2 is extremely effective at, as the main driver behind regrowth. Castrates generally do not regrow any hair, but they do not have the AR suppression that E2 may provide. Backdoor and adrenal androgens are still abundant in castractes and local synthesis of DHT can still happen at a rate high enough to make regrowth impossible (5AR is highly expressed in the skin, making even minute amounts of residual testosterone dangerous for hair). Theoretically, a highly effective regimen for regrowth would consist of an antiandrogen to prevent AR binding, E2 to prevent AR upregulation as a response, and a 5ARI to remove highly potent androgens (DHT). Using an AA would probably be superfluous for people on HRT already, but it would not hurt either. I also postulate that such a regimen would be highly effective when used topically as well, which is the only viable option for males (even then, it is risky and should not be done without sufficient background knowledge).

 

[JaneyElizabeth]

I absolutely agree. HRT can definitely regrow hair everywhere on the head as proven countless times. However, we do not know the exact mechanism behind it - is it due to actual transcriptional activity at the ER or just AR suppression? Studies actually point to the latter, hence I am more and more leaning towards AR suppression, which E2 is extremely effective at, as the main driver behind regrowth. Castrates generally do not regrow any hair, but they do not have the AR suppression that E2 may provide. Backdoor and adrenal androgens are still abundant in castractes and local synthesis of DHT can still happen at a rate high enough to make regrowth impossible (5AR is highly expressed in the skin, making even minute amounts of residual testosterone dangerous for hair). Theoretically, a highly effective regimen for regrowth would consist of an antiandrogen to prevent AR binding, E2 to prevent AR upregulation as a response, and a 5ARI to remove highly potent androgens (DHT). Using an AA would probably be superfluous for people on HRT already, but it would not hurt either. I also postulate that such a regimen would be highly effective when used topically as well, which is the only viable option for males (even then, it is risky and should not be done without sufficient background knowledge).

That's one of the best comments that I have seen and it reflects what many MtF's tell me and even gals in their 20's might not get regrowth. But why, Goddess-Damit why? A lot of this stuff is all but circular so that makes it difficult to determine. I know less about receptor activity than I do about all female HRT meds.

You touch on one of my ideations which is that beard growth and scalp hair growth are just two different places to be hairy and yes, beards go bald too. It might be that laser hair-removal might help restart hair growth. HRT did nothing or my dermatitis on my face; yep, beard removal cured that too. Yes, it wasn't that long ago that people were gaslighting MtF's who stated that they re-masculinized after castration. Rob English seems to think that both elimination of DHT plus estrogen might result in full or almost full restoration but shh. I don't want to jinx it. I have been under 10pg/ml my last two tests with the lab but I also have hit some extremely high numbers.

Once I used an entire tube of Estrogel in a day and I was regularly around pregnancy levels for E2 which correlated with hair regrowth but I have been using estrogen of USP quality so I might argue that it took all 7 of those transition years and my hair just got better and better but it feels much more like I induced this recently and I still think that extremely high E2 levels might be worth trying along with oral min for folks who are not seeing hair improvement. Mine is getting longer and less disruly but I still look better in my wig because hair length makes a huge difference in terms of passing as does, sigh, breast growth.

 

[Almas]

Effective Testosterone Suppression for Prostate Cancer: Is There a Best Castration Therapy?

Achieving and maintaining effective suppression of serum testosterone levels in men treated with androgen ablation is one of the essential strategies in the management of prostate cancer. Historically, a serum testosterone below 50 ng/dL was considered ...

www.ncbi.nlm.nih.gov

Hair growth is provided by a decrease in the T level to the castration level and an increase in the E level
T levels below 50 ng / dl are normal, but the ideal level is less than 20 ng / dl, this corresponds to castration levels and affects prostate cancer outcomes. Thus, we need to reduce T as much as possible. To do this, our E levels must be at least 250-300 ng / dL
It is not advisable to raise estradiol levels above 700 pg / ml, because in this case SHBG will go crazy, the level of free estradiol will decrease. This reduces the effectiveness of HRT. Therefore, "one cannot be mistaken in the big direction" is not quite a true statement. Ideal E levels are in the 300-700 pg / ml range, SHBG levels below 115. But because the main thing is to lower the T level to the castration level, then the error in the big direction is not as critical as in the lower one, and you will still get the result

If you do injections of Enanthate every 2 weeks with a minimum of 300 pg / ml on the last day, then according to my calculations, the peak level is around 1500 pg / ml, which is a lot. If injections are done once a week, then the peak level at the same minimum does not exceed 700 ng / dl. Therefore, I will consider giving injections once a week.

The Ikarus T level was above 100 ng / dl and the E level was 195 pg / ml. These are poor numbers and this could be one of the reasons why he was unable to restore the hairline.


View attachment 165180

Injections are ideal for T suppression because they are easiest to reach 250 + pg / ml estradiol, which will give you castration T levels below 20 ng / dL. Castration levels of T + estradiol give the best chance of success
My level is now 35 pg / ml, which is not bad either.