Exploring The Hormonal Route. Hair=life.

[Experimentality]

Unfortunately there is only the abstract available of the article that tested balding scalp derived DP cells, but it seems, with the limit of the in vitro model, the cells response break point happen at a lower concentration: >36 nM, so maybe 2X , so 72 nM?
The full text study says cell proliferation was increased starting from 180 nM and the study on hair shaft elongation model in vitro says 100 nM is suitable (even not optimal like the 10 nM).
I would go for a compromise concentration of 200 nM, that should be realized by a topical at 0.001 % order of magnitude, but you can make the math with your model based with the vehicle you have selected. Even assuming a full scalp application, namely 2 ml, the total estradiol would be 0.02 mg, that I don't think it's enough to cause unwanted sides.
I'm going to run a similar test with WAY-200070 and RU (just because I don't have a better AA in my hands now).

Thanks. Yes, I think these concentrations are in the ballpark where we want to be with such a topical regimen. 1mcg/mL (0.0001%) would give concentrations around 100nM (1000 times the EC50 value of 0.1nM, order of magnitude). I think 10mcg/mL (0.001%) is too much, since the concentration will then be closer to 1uM. Experimenting with WAY can probably give similiar results (since the scalp hardly has ER-alpha expression anyway), however I think it is redundant because E2 in such low quantities will not give systemic sides anyway, and it is way (no pun intended) more expensive and harder to source than plain E2. I am also still not sure if WAY is a full agonist of the ER-beta, which is a requirement to be effective. I have never seen evidence that this is the case, which makes me sceptical. For an AA, RU is absolutely inferior to Apalutamide or Darolutamide. I recently switched to Darolutamide (because the half-life is more favorable than Apalutamide) and it is really only needed at 0.1% (that may be overkill as well). Add in Finasteride or Dutasteride and the whole balding cascade has essentially been shut down. I really like how everything works in tandem:

-Finasteride/Dutasteride removes the most potent androgen (DHT), which increases the efficiacy of the AA.
-Darolutamide/Apalutamide blocks the AR, will cause AR upregulation.
-E2 directly counteracts AR upregulation.

I added Cyclosporine A (at 0.1%) because the extensive research I ran on it points at a reasonable safety profile at such topical concentrations. Cyclo addresses many problems of the balding cascade: in addition to stimulation the Wnt pathway by inhibiting sFRP-1, it also provides direct suppression of interleukins which are further down the chain (they are produced as a reaction of an androgen binding de AR in a "male pattern baldness-sensitive" follicle). So, it is both a growth stimulant through Wnt as well as a preventive agent through inhibiting IL's. Some people are running WAY-316606 instead, but that compound only inhibits sFRP-1 (and does nothing to counteract IL's).

I am still torn on Minoxidil (sulfate). It is very effective as a growth simulant, but it gives me horrible skin texture. Currently I am not using it and not really planning on using it again. If you can run it without any bothersome sides I would definitely include it in the topical formulation. Another bonus of the topical is that all drugs are FDA-approved: long term effects are all known and safety warnings have been published where applicable. I still recommend anyone who wishes to try this to research everything you are going to use extensively. FDA approved does not necessarily mean safe or without side effects.

 

[JaneyElizabeth]

If my body ended up looking like that I would be pretty happy. Even the persons breast growth looks quite acceptable and easy to hide in those pictures.

That's fairly typical for many but eh, not me.

 

[JaneyElizabeth]

I kind of don't mind your illeism, it make you unique, and conversations with you are interesting, even more so with your quirks

Right, hence the absent-minded professor stereotype.

 

[Pls_NW-1]

Where'd Tato go? I miss him. I didn't know that about the bica. And what's your plan again? You amassed all of this knowledge for nothing the way that the world sees things but not Janey. All knowledge, particularly when acquired freely and on purpose is to know the infinite, a tiny bit more towards that goal janey says.

I currently can't take any medication due to having an unknown reasoning for hormonal imbalance. I will keep you guys updated after my appointment for the mrt investigation of my abdomen.

 

[Pls_NW-1]

Yes, that's true that it's pretty heavy on the liver. But apparently at doses up to 150mg it's not too bad. Definitely safer then other AAs. But still I will do a liver functions blood test after a month on it, just to be sure everything is ok.

I don't think gyno should be too bad with monotherapy, with doses up to 150mg. Cancer patients tend to get much bigger doses, and most side effect studies are done on them. And yes I agree that every drug has it's risks, even Finasteride. What you do depends on how much you value hair, for me the answer is a lot.

You can check out my post history if you want to get more infos on bica, I re-disscused it with a lot of users back then. And yes, I agree at your statements. The best AA imo is bicalutamide.

 

[Pls_NW-1]

I think many people exaggerate the effects of HRT on the body. Although it certainly is, it is also individual

https://imgur.com/a/tZj1G

This person literally has milkers. I dunno what you guys think, but imo this is a no go for a male, I think gyno surgery or breast reduction won't do much, because you wouldn’t achieve stereotypical aesthetics. No HRT for me, sorry boyos.

 

[Almas_NW0]

This person literally has milkers. I dunno what you guys think, but imo this is a no go for a male, I think gyno surgery or breast reduction won't do much, because you wouldn’t achieve stereotypical aesthetics. No HRT for me, sorry boyos.

The breast is a completely solvable problem with the help of surgery. If you don't use HRT for too long, your physique will not become noticeably feminine, you will continue to look like a guy. HRT is overrated as a feminization tool. Without plastic surgery and cosmetics, this is not so much and will not turn you into a woman. In addition, hair and face have a greater influence on beauty.

Of course, it's up to you. But I want to be beautiful. And HRT helps me with this

 

[Catagen]

This person literally has milkers. I dunno what you guys think, but imo this is a no go for a male, I think gyno surgery or breast reduction won't do much, because you wouldn’t achieve stereotypical aesthetics. No HRT for me, sorry boyos.

Bodyfat distribution is also fucked up, more at the pelvis which is pretty bad. To avoid gyno you would have to cut the gland out completely before you start HRT and even then you might get more bodyfat there forcing you to be skinny.

 

[LouisSarkozy]

The breast is a completely solvable problem with the help of surgery. If you don't use HRT for too long, your physique will not become noticeably feminine, you will continue to look like a guy. HRT is overrated as a feminization tool. Without plastic surgery and cosmetics, this is not so much and will not turn you into a woman. In addition, hair and face have a greater influence on beauty.

Of course, it's up to you. But I want to be beautiful. And HRT helps me with this

what's the most significant effect on your face ? did it reverse skin aging and makes you look younger?

 

[JaneyElizabeth]

You can check out my post history if you want to get more infos on bica, I re-disscused it with a lot of users back then. And yes, I agree at your statements. The best AA imo is bicalutamide.

This used to be Bica Central or All Bica, All of the Time says janey.

 

[JaneyElizabeth]

This person literally has milkers. I dunno what you guys think, but imo this is a no go for a male, I think gyno surgery or breast reduction won't do much, because you wouldn’t achieve stereotypical aesthetics. No HRT for me, sorry boyos.

Certainly not because of size? Cause Bridge was way larger than that...

 

[JaneyElizabeth]

Bodyfat distribution is also fucked up, more at the pelvis which is pretty bad. To avoid gyno you would have to cut the gland out completely before you start HRT and even then you might get more bodyfat there forcing you to be skinny.

FtM surgery seems to bear out your warnings. Bridge, regardless janey continues on out here as your ahem, alter boy whenever you ask<bats eyes and then winks<<

 

[Solxama]

The breast is a completely solvable problem with the help of surgery. If you don't use HRT for too long, your physique will not become noticeably feminine, you will continue to look like a guy. HRT is overrated as a feminization tool. Without plastic surgery and cosmetics, this is not so much and will not turn you into a woman. In addition, hair and face have a greater influence on beauty.

Of course, it's up to you. But I want to be beautiful. And HRT helps me with this

You are absolutely right with the beauty aspect. Being a bald, hairy all over the body, wrinkled man is simply ugliness. And that would be my future If I didn't start HRT. I look forward to Estrogen making me look cute and more androgynous

Bodyfat distribution is also fucked up, more at the pelvis which is pretty bad. To avoid gyno you would have to cut the gland out completely before you start HRT and even then you might get more bodyfat there forcing you to be skinny.

Well I hope staying skinny helps me minimize gyno, but something like in the pictures @Almas_NW0 shared is fully acceptable to me, it's literally not big at all compared to some of the breast growth from HRT I've seen online.

You can check out my post history if you want to get more infos on bica, I re-disscused it with a lot of users back then. And yes, I agree at your statements. The best AA imo is bicalutamide.

Yeah, your discussions with other users, mostly with Almas about Bica were something I read when lurking this thread, and they did play a part in me deciding to go with it as my AA. There is very interesting information in those discussions.

 

[JaneyElizabeth]

You are absolutely right with the beauty aspect. Being a bald, hairy all over the body, wrinkled man is simply ugliness. And that would be my future If I didn't start HRT. I look forward to Estrogen making me look cute and more androgynous


Well I hope staying skinny helps me minimize gyno, but something like in those pictures @Almas_NW0 shared is fully acceptable to me, it's literally not big at all compared to some of the breast growth from HRT I've seen online.


Yeah, your discussions with other users, mostly with Almas about Bica were something I read when lurking this thread, and they did play a part in me deciding to go with it as my AA. There is very interesting information in those discussions.

Yes. That's the hope for many boys she says but Goddess blessed Will to the proverbial hilt.

 

[JaneyElizabeth]

You are absolutely right with the beauty aspect. Being a bald, hairy all over the body, wrinkled man is simply ugliness. And that would be my future If I didn't start HRT. I look forward to Estrogen making me look cute and more androgynous


Well I hope staying skinny helps me minimize gyno, but something like in the pictures @Almas_NW0 shared is fully acceptable to me, it's literally not big at all compared to some of the breast growth from HRT I've seen online.


Yeah, your discussions with other users, mostly with Almas about Bica were something I read when lurking this thread, and they did play a part in me deciding to go with it as my AA. There is very interesting information in those discussions.

Strangely you forget that one of us said no AA needed at all but I shan't say says janey....

 

[JaneyElizabeth]

Yes. That's the hope for many boys she says but Goddess blessed Will to the proverbial hilt.

It's gotta be the beards janey says and so yes, at first we like the stubble cause it looks like a "man" but it keeps growing and growing and growing while we are shedding, shedding, shedding and then before you know it, the body drops out on scalp hair much more quickly than you could have though and it is unsettling psychologically but Will never asked for this<janey shudders>

 

[Solxama]

Yes. That's the hope for many boys she says but Goddess blessed Will to the proverbial hilt.

Literally I don't understand how can some people be ok with being bald. At the moment I realized that if I do nothing my future would be a dysphoric mess of ugliness, I thought to myself screw masculinity, I never liked it anyway but that realization was what drove me over the edge.

Strangely you forget that one of us said no AA needed at all but I shan't say says janey....

I know it's not really needed but I want to be on the safe side to start off. I want everything to do with Androgens out of my body. That means I want low T, blocked Androgen Receptors and no DHT production. The AA is there just to be certain that Androgens are no longer screwing up my body. I will probably drop Bica at some point and switch to high dose E2 injections. I plan to stay on HRT for life so I'll have a lot of time to experiment.

 

[JaneyElizabeth]

https://aeon.co/ideas/acting-changes-the-brain-its-how-actors-get-lost-in-a-role is similar to just in it for the hair.

 

[Solxama]

https://aeon.co/ideas/acting-changes-the-brain-its-how-actors-get-lost-in-a-role is similar to just in it for the hair.

Well I read the article and I know what you are trying to imply, that HRT can change a person's mindset and personality even if they don't expect it. Well my opinion about this is, like I already stated many times, that if it happens it happens. Literally anything is better then balding and further masculinization for me.

 

[JaneyElizabeth]

Well I read the article and I know what you are trying to imply, that HRT can change a person's mindset and personality even if they don't expect it. Well my opinion about this is, like I already stated many times, that if it happens it happens. Literally anything is better then balding and further masculinization for me.

No, I mean, it's enjoyable unless people are literally trying to make you feel as though you are off. If an alter comes out, either establishing themself or as part of a duo, it can me really be unnerving and circular about who runs what or is blamed for what. Why did I need this so much vs. how could anyone not see why I need this and I am consumed by it.