@Einstein i had the same problem you describe. I ended up cutting my dosage in half (2.5mg morning, 2.5mg night) and the frequency/severity for which I had the intensely puffy eyes (I had it every day until noon-ish) subsided greatly. The good news is that I didn’t see a decrease in the efficacy of the oral minoxidil when doing this. Oral minoxidil >>>> topical if you can do it safely.
Like a couple others in this thread, I monitored my blood pressure several times a week for the first few weeks to ensure it was okay for me to take. I first got a baseline, then started taking the drug and went to a local CVS to get my pressure taken (they didn’t have an automated machine, but the pharmacist had no problem coming out and taking it manually for me). My bp did change a bit, but then leveled off back to baseline..:if I recall correctly, I have a pretty low resting heart rate (low 40s, maybe— it’s been a while), so once the bp decrease a little bit, my hr increased slightly to make up for it. Not by any extremes, and I was/am still very much well in the safe / healthy range. For everybody else reading this, before going full trottle into loniten, please do your due diligence.