Fluridil and shutting down AR! (best idea?)

[Bryan]

There aren't any studies that I know of that show that, but I'd be very surprised if the cell didn't respond in the same to androgen receptor blockage that it does to DHT suppression.

BTW, just for the sake of completeness, I should mention here that a famous name in hairloss research (you'd recognize the Doctor's name if I were to mention it) apparently doubts Sawaya's findings in the first place that finasteride usage causes an alleged "upregulation of androgen receptors". I don't know for sure who is right and who is wrong about that, but I tend to lean in favor of Sawaya...

Bryan

 

[viperfish]

Bryan,
Did you ever read the other study that I posted? I know I did once awhile back, but I can't seem to come across it now. I have no clue where I was able to download it from without paying for it. :roll:

 

[bombel]

bombel, You say you thought you had good results. Then you say Fluridil didn't work for you. Did it stop your hairloss or did it not work for you because you couldn't handle the high alcohol content and it made you hair look like sh*t in the morning?

Thing is, I don't see the problems with my hair like some of the others. I'm losing a normal amount of them each day. I just noticed that they do not regrow and so I've been having bigger and bigger problems with my hairline.

As for the start I used minoxidil based product for regrowth and eucapil as the blocker. I had a small regrowth here and there but nothing spectacular. And in addition I had shitty-looking hair. Maybe it was a good direction to use eucapil for a year or so, but I just had to stop. I care about how mu hair look like. The eucapil-effect was just not acceptable

 

[bombel]

I used it for a few months as one of the very first things I used to stop hairloss. I thought I had good results, but I was not sure if it is of minoxidil or eucapil

It's expensive and for me not worth the money. I have very long hair and that alcohol was messing them so much, that I had to stop it! They say, that you should not wash your hair too often while using it, but I was not able to wash my hair other than once a day, because my hair looked like sh*t after I was waking up (I used eucapil before going to bed)

So, these are my thoughts. Some people claimed it worked for them. It certainly didn't for me

Dan

You used eucapil for 2 months? How can you even begin to conclude that it did not work? Unless, I'm misunderstanding you here? Interpharma Praha now claims that you can wash your hair every morning if you want.

Where did I say that I used it for 2 months? I've written 'a few months' and if I remember well, it was about 5-6 months.
They claimed it's recommended to wash your hair not often than twice a week or so (maybe because of water<->eucapil interaction) Maybe they changed it - I don't know. I don't read their news since I dropped the product

So just to be clear - I think it didn't work for me. It's pretty expensive and I really expected some noticable results after a few months. I haven't seen that, so I dropped it

 

[viperfish]

I used it for a few months as one of the very first things I used to stop hairloss. I thought I had good results, but I was not sure if it is of minoxidil or eucapil

It's expensive and for me not worth the money. I have very long hair and that alcohol was messing them so much, that I had to stop it! They say, that you should not wash your hair too often while using it, but I was not able to wash my hair other than once a day, because my hair looked like sh*t after I was waking up (I used eucapil before going to bed)

So, these are my thoughts. Some people claimed it worked for them. It certainly didn't for me

Dan

You used eucapil for 2 months? How can you even begin to conclude that it did not work? Unless, I'm misunderstanding you here? Interpharma Praha now claims that you can wash your hair every morning if you want.

Where did I say that I used it for 2 months? I've written 'a few months' and if I remember well, it was about 5-6 months.
They claimed it's recommended to wash your hair not often than twice a week or so (maybe because of water<->eucapil interaction) Maybe they changed it - I don't know. I don't read their news since I dropped the product

So just to be clear - I think it didn't work for me. It's pretty expensive and I really expected some noticable results after a few months. I haven't seen that, so I dropped it

Oh, sorry! I thought you said you only uised it for two months. I would agree that it does have a slight impact on the cosmetic appearance of the hair. Did you use the newer version of eucapil with the grape seed oil??

 

[Full Head of Hair]

You're only reccomended to wash your twice a week on eucapil???

 

[viperfish]

You're only reccomended to wash your twice a week on eucapil???

Now they say you can wash it every morning if you wish.

 

[bombel]

I used it for a few months as one of the very first things I used to stop hairloss. I thought I had good results, but I was not sure if it is of minoxidil or eucapil

It's expensive and for me not worth the money. I have very long hair and that alcohol was messing them so much, that I had to stop it! They say, that you should not wash your hair too often while using it, but I was not able to wash my hair other than once a day, because my hair looked like sh*t after I was waking up (I used eucapil before going to bed)

So, these are my thoughts. Some people claimed it worked for them. It certainly didn't for me

Dan

You used eucapil for 2 months? How can you even begin to conclude that it did not work? Unless, I'm misunderstanding you here? Interpharma Praha now claims that you can wash your hair every morning if you want.

Where did I say that I used it for 2 months? I've written 'a few months' and if I remember well, it was about 5-6 months.
They claimed it's recommended to wash your hair not often than twice a week or so (maybe because of water<->eucapil interaction) Maybe they changed it - I don't know. I don't read their news since I dropped the product

So just to be clear - I think it didn't work for me. It's pretty expensive and I really expected some noticable results after a few months. I haven't seen that, so I dropped it

Oh, sorry! I thought you said you only uised it for two months. I would agree that it does have a slight impact on the cosmetic appearance of the hair. Did you use the newer version of eucapil with the grape seed oil??

Yes, I did..

 

[Norwoody]

I'm not quite sure I understand your questions. Let me make some general comments about androgen receptors: they are a specific complex protein that's produced by certain androgen-sensitive cells, just like any other protein. That protein is coded for by a certain gene (there's also apparently an "A" and "B" form of the androgen receptor, but let's not get in over our heads here! :wink: ). Like other proteins, it's produced by the cells on a regular basis, with a steady turnover as old proteins eventually get degraded and replaced by the new ones. The androgen receptors are dispersed through the cell's cytoplasm, as they await the binding of androgen molecules. Once they bind with androgens, the receptor/androgen complex migrates to the cell's nucleus where it binds with DNA to stimulate the activation of various androgen-sensitive genes (which may well include the gene which codes for the production of the androgen receptors themselves!).



As I indicated before, they are being produced steadily, with a regular turnover. According to one physiology textbook I've read, a typical cell may contain somewhere around 3,000-10,000 androgen receptors at any one time. Their production may be stimulated (or "upregulated") by certain conditions. For example, Sawaya claims to have found an intense upregulation of the production of androgen receptors in men who use finasteride. If that's correct, it's probably a natural "balancing" mechanism, as the cell attempts to maintain a certain level of androgenic stimulation.

The doctors who wrote that fluridil study seem a little vague to me about their claims for the drug. They _appear_ to be saying that it's an androgen receptor blocker like spironolactone and RU58841, but then they also seem to be saying that it may also downregulate the production of androgen receptors. I wish we could get a clarification of that! They may not know for sure THEMSELVES exactly what all the drug does.

Bryan

@DoctorHouse Legendary posts back when the forum wasn't a breeding ground for trolls.