Hairhaircomeagain,
Ive seen Dr. Peter Proctor advise some folks to try to counteract baldness for the time being on all fronts. That would be to cut DHT, inhibit androgen receptors, repair tissue/counteract the immune response, fight inflammation, use a growth stimulant.
A life extension and bodybuilding writer that is well-known named Will Brink, has stated that using proxiphen, nizoral a couple of times a week and propecia is proboably about the best one could do for the time being. He is hoping for a really effective long-lasting receptor blocker like RU58841 to get approved here to add to that.
Problem is (for me anyway) proxiphen is a hundred damned bucks a month. But all it is is sprio/minoxidil/phenytoin (epilepsy drug that grows hair for some reason) and prox-N.
Prox-N can be had for 25 a month, minoxidil for 6 bucks, and spironolactone at Genhair.com for about 15. If you add propecia bought generically in the form of proscar..................that would be fifty five or so bucks, about the cost of prescript propecia for an effective receptor blocker twice a day, growth stimulant and anti-collagen agent in minoxidil, a superoxide dismutase, skin-remodeling copper peptide that should help counteract the immuno attack some in prox-n, and a type two alpha five reductase inhibitor in finasteride, and an anti-inflammatory with some growth stimulating properties and apparently weak anti-androgen activity in the ketoconazale shampoo, nizoral.
Folligen, of which a big-bottle that might last you nearly a year if applied every other night like Pickart advises, is only forty bucks if Prox-N is too pricey. It does not have the other SOD's other than the copper peptides themselves, however. The ingredients otherwise were about the same (Ive checked). The other SOD/Copper peptide products are Tricomin, American Crew Revitalising serum/spray, and Nanosal (new one). There is also Graftcyte out there still I think.
Ive considered (and bought a months supply of a bunch of things to see if I felt like they'd work). Fluridil is intriguing, but it gets scewed up by other topicals and degenerates in water. Revivogen, which I tested on a part of my arm to see if its anti-androgenic activity could reduce the body hair on the arm, impressed me in the fact that it did so quite well (even in spite of the fact that it has proanthocyanidrins (a growth stimulant) therein. That stuff can be had for less than thirty a month, and gives DHT inhibiton of type one and two, plus a growth stimulant. I tried Crinagen on the other wrist, and it didnt do anything except give me a bit of a rash.
I guess in the area of whats proven.....if you put a gun to me and said what should work.....that would be 1/Propecia or Dutasteride if youre
adventurous
2/spironolactone 2X a day applied with
3/Prox-N
4/minoxidil at least once a day
5/Nizoral 2X a week, possibly
mixed once with a bit of T-Sal
shampoo also
Other cheaper anti-inflammatory shampoos are a Salycic acid shampoo from the drug store brand, a Coal Tar shampoo like T-Gel or drug store brand, or a pyrithone zinc ant-dandruff shampoo like some Head and Shoulders brand instead of Nizoral if youre on a budget.
Another growth stimulant other than minoxidil that reportedly is good are proanthocyandrins which are almost assuredly found in apple cider vinegar that you could use in a shampoo pre-soak for a few minutes before the shower. I understand that this helps drive toxins out of the scalp or some such also. There is a company that makes spray-on proanthocyandrins and one study compared them favorably to minoxidil, but minoxidil has been proven over and over to grow hair. Research it yourself. Apple Cider Vinegar though, if you have no growth stimulant in your regimine, is EXTREMELY cheap. A bottle cost about a dollar for a cola-sized container. Apparenlty that stuff is used in cooking.
You know hairhaircomeagain,
When you think about it, the difference in those of us who lose our hair isnt we have more DHT (although we might have a bit more skin testosterone), or that ALL of us necessarily have more androgen receptors (the variant of the androgen receptor gene that 98.6 percent of bald men have is shared by 76 percent of non-bald men too). Its some chemical signals that happen in the dermal papilla when enough DHT (perhaps some other male hormones too) gets transcripted in our androgen receptors. What goes on in the papilla, is what really starts the whole damned thing. We know that instead of growth factors (mitogens), the papilla in us balding guys sends out antigens (inhibitors) to the rest of the follicle cells. Apparently the immune system senses this struggling micor organ (the hair unit) isnt part of you that is supposed to be there and attempts to kill it.
Im hoping some "smart" topicals can be created to nix this, but in truth cloning will proboably be there before then. I just got a letter back from Alpecin cosmetic that made me think of this. I asked them if they thought caffeine might interefere with androgen receptors. They told me no, and that their product worked by increasing the activity of the energy-messenger cAMP. They claim they have confirmed this in clinical trial biopsies of living hair organs (about 600 hairs in an experiment), and that they are going to get this published by the International Journal of Dermatology. Now Alpecin may very well be junk, BUT this is the kind of thing I hope to see in the future..............a shampoo or quick after shower liquid, that can get in the papilla and contradict the negative instructions being sent out to the rest of the follicle. That we we wouldnt have to scew with our hormones at all. You know when you think about it, even if you just use Revivogen and "block" the activity of scalp alpha five reductase type 2 found in the follicle and type 1 found in the sebaceous glands, and sebocytes.............................youre still "screwin" with your hormones. The Testosterone that DIDNT get changed into DHT like it would have, is coursin' through your veins when it wouldnt have been. Its not the androgens in a way.............its what the papilla does that starts this process in all proboability. Of course one week from now someone is gonna do a study proving that DHT binds to receptors in some freakish pattern and THAT sets off the immuno response making a fool out of my thinking out loud, but thats what Im goin with today.
What Bryan stated about the complexity of baldness is very true. Lotta bald scientist to research this gunk in their spare time, havent cured it yet. It sucks, dammit.
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