Search HairLossTalk.com, many(subjective term) have found success in using higher dose vitamin d either by itself or with other things.
For Your Viewing Pleasure-Vitamin D Deficiency & Hair Loss: A Case Report
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Stepping thru a few of observations noted in table 1:
1) androgens- already discussed above and dht is used by the body to mitigate vit d deficiency.
2) inflammation- broad topic but interferes with IL-17 and stops peroxynitrite formation too.
Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson's Disease - PubMed
Parkinson's disease (PD) is a chronic low-grade inflammatory process in which activated microglia generate cytotoxic factors-most prominently peroxynitrite-which induce the death and dysfunction of neighboring dopaminergic neurons. Dying neurons then release damage-associated molecular pattern...
pubmed.ncbi.nlm.nih.gov
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Vitamin D can regulate the production and degradation of prostaglandin D2 (PD2) and other inflammatory substances, such as prostaglandin E2 (PGE2):
4) microrganism- unknown probably thru sebum
5) fibrosis- inflammation disrupted by vitamin d
6) blood vessel calcification-
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Yes, vitamin D deficiency can contribute to capillary calcification:
- Vitamin D deficiency and CAC
Vitamin D deficiency can increase the risk of developing coronary artery calcification (CAC) in people who don't already have CAC. - 7) sebaceous gland size-
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Vitamin D levels and sebaceous glands are related in several ways:- Sebaceous gland function
Vitamin D can inhibit the proliferation, differentiation, and secretion of sebum, which are all key factors in sebum production.
- Sebaceous gland inflammation
Vitamin D can inhibit the upregulation of inflammatory biomarkers by P. acnes and UVB irradiation.
- Seborrheic dermatitis
Low vitamin D levels are associated with seborrheic dermatitis, and patients with severe vitamin D deficiency develop it earlier.
- Acne
Vitamin D deficiency can potentiate the inflammatory process in severe acne patients.
- Sebaceous gland therapy
Sebaceous glands may be potential targets for therapy with vitamin D analogues.
- Sebaceous gland function
- 8) vascularity-
The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus
- https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-015-0029-y
9) - APM- unknown but probably inflammation related
- 10) skull shape-
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Vitamin D deficiency can cause a skull shape abnormality in newborns and infants called craniotabes, which is characterized by soft, thin skull bones that deform when pressure is applied:
Other signs of vitamin D deficiency in children include:Craniotabes Description Soft, thin skull bones that deform when pressure is applied Effect Skull bones may remain soft and malleable for a longer period, predisposing the infant to skull deformation Signs Skull bones collapse inward when pressure is applied, but snap back when the pressure is relieved Associated conditions Rickets, congenital syphilis, and osteogenesis imperfecta Treatment Oral cholecalciferol supplementation can normalize serum 25-hydroxyvitamin D levels and resolve the skull softening - Slow growth
- Uneven teeth
- Slow walking and crawling
- Wide fontanelles
- Deformed ribs and rib cage
- Scoliosis and bow legs
11)GA AKA galea aponeurotica- muscle contraction problems occur in muscular dystrophy 1 patients too(who also get Androgenetic Alopecia) and are helped by vit d supplementation and short term effects with botox for Androgenetic Alopecia.
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The galea aponeurotica is a dense fibrous membrane that underlies hair follicles that are prone to androgenic alopecia (Androgenetic Alopecia). Androgenetic Alopecia is a common hair loss disorder that causes progressive, patterned hair thinning in the scalp regions above the galea aponeurotica.
Here's some information about Androgenetic Alopecia and the galea aponeurotica:- Pathogenesis
Androgenetic Alopecia is thought to be caused by a combination of genetics and androgens, particularly dihydrotestosterone (DHT), a metabolite of testosterone. DHT attaches to an androgen receptor in Androgenetic Alopecia-prone hair follicles, which can lead to hair follicle miniaturization.
- Scalp tension
A hypothetical model suggests that chronic scalp tension from the galea aponeurotica can cause an inflammatory response in Androgenetic Alopecia-prone tissues. This response can lead to the thickening of the dermal sheath, perifollicular fibrosis, and calcification, which can restrict the growth space, oxygen, and nutrient supply for hair follicles.
- Pathogenesis
Frontiers | Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health
Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, ...
www.frontiersin.org
Furthermore, mounting evidence suggests that vitamin D may play an important role during muscle damage and regeneration. Muscle damage is characterized by compromised muscle fiber architecture, disruption of contractile protein integrity(ME:meaning the galea aponeurotic muscle is never/partly contracts hense the effectiveness of botox), and mitochondrial dysfunction
12) muscular- mentioned above:
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When I was living at home my mother would basically always recommend I drink milk which is vitamin d3 fortified . I was never a fan of cow milk and definitely tried to minimize it. I started balding at about age 17 around the age of when I was starting not to prefer milk.
There are some threads around about the association with heavy sweating with male pattern baldness. Here's one but there are more around:
In high school when I started balding and always outsweated my team mates like 3 to 1 that could have been the start of the deficiency. Not to mention it seemed like I had chronic fatigue syndrome too.
www.youtube.com
The thing is...vitamin d3 isn't going to work for everybody about like everything else. I'm pretty sure over 50% of the US population is deficient in vitamin d and I don't even have to take a test because: I eat no fatty fish, don't drink vit d3 enriched milk and not in the sun that much.
Some videos about d3 and K2.
This guys vitamin d3 figures out after conversion to 230 ng/ml which is 2x the upper limit range. 30-100 is supposedly normal. The guys vitamin d3 is off the charts yet he doesn't suffer from hypercalcemia.
Vitamin d3 looks like it didn't work too well for Dr. Mandell:
Yet it looks like it worked for this guy that caught it early:
Worked here too:
www.youtube.com
Don't overdose or especially without K2 this may happen:
So..clearly vitamin d3 is involved with the Androgenetic Alopecia process BUT WHY doesn't it work for everybody? Aside from the always correct genetics answer could it be the capillaries were already too calcified to benefit them?
There are some threads around about the association with heavy sweating with male pattern baldness. Here's one but there are more around:
In high school when I started balding and always outsweated my team mates like 3 to 1 that could have been the start of the deficiency. Not to mention it seemed like I had chronic fatigue syndrome too.
8 Signs Your Body Is Begging for Vitamin D
What are the signs of vitamin D deficiency? Vitamin D greatly influences the systems of our body from ensuring calcium supply to our bones to strengthening o...
www.youtube.com
The thing is...vitamin d3 isn't going to work for everybody about like everything else. I'm pretty sure over 50% of the US population is deficient in vitamin d and I don't even have to take a test because: I eat no fatty fish, don't drink vit d3 enriched milk and not in the sun that much.
Some videos about d3 and K2.
This guys vitamin d3 figures out after conversion to 230 ng/ml which is 2x the upper limit range. 30-100 is supposedly normal. The guys vitamin d3 is off the charts yet he doesn't suffer from hypercalcemia.
Vitamin d3 looks like it didn't work too well for Dr. Mandell:
Yet it looks like it worked for this guy that caught it early:
Worked here too:
HAIR LOSS NIGHTMARE? DISCOVER THE SECRET TO RAPID REGROWTH WITH VITAMIN D
HAIR LOSS NIGHTMARE? DISCOVER THE SECRET TO RAPID REGROWTH WITH VITAMIN DToday, we're examining clinical case studies on vitamin D supplementation for hair r...
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Don't overdose or especially without K2 this may happen:
So..clearly vitamin d3 is involved with the Androgenetic Alopecia process BUT WHY doesn't it work for everybody? Aside from the always correct genetics answer could it be the capillaries were already too calcified to benefit them?
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So the non-responders to vitamin d probably have a VDR mutation while those who do respond are just low in vitamin D.
Yes, vitamin D receptor (VDR) mutations can cause hair loss, including androgenetic alopecia:
The occurrence of alopecia depends on the location of the VDR mutation. For example, mutations in the VDR-RXR interaction domain can cause alopecia, but mutations in the ligand-binding domain do not.
Children with VDR defects that cause alopecia may require intravenous calcium infusions to bypass the defective VDR. There is no cure for androgenetic alopecia, but holistic therapies may help halt the process and boost hair growth.
Yes, vitamin D receptor (VDR) mutations can cause hair loss, including androgenetic alopecia:
- Alopecia
A clinical feature of hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR), which is caused by VDR gene mutations. Alopecia can include sparse body hair, lack of eyebrows and eyelashes, or total scalp and body alopecia.
- Androgenetic alopecia
Vitamin D deficiency may be associated with early onset androgenetic alopecia.
- Derepressing genes: The unliganded VDR can lose its suppressor activity, which may derepress genes that lead to alopecia.
- Disrupting ligand binding: Mutations can disrupt the VDR's ability to bind to ligands like calcitriol.
- Disrupting DNA binding: Mutations can disrupt the VDR's ability to bind to DNA.
The occurrence of alopecia depends on the location of the VDR mutation. For example, mutations in the VDR-RXR interaction domain can cause alopecia, but mutations in the ligand-binding domain do not.
Children with VDR defects that cause alopecia may require intravenous calcium infusions to bypass the defective VDR. There is no cure for androgenetic alopecia, but holistic therapies may help halt the process and boost hair growth.
There are probably "back doors" to getting around a VDR mutation..Many of the compounds mentioned below have been tried but what was their vitamin d status? Does the success of treatments hinge around vitamin d in adequate levels? What if a person has an adequate vitamin d level but still has inherited resistance?
www.mdpi.com
Vitamin D resistance can be inherited or de novo acquired; in the former case is caused by the mutation of VDR or RXR genes or the genes involved in calcitriol activation, catabolism, and signaling, in the latter case the resistance can be environment-dependent.
The resistance to vitamin D could be overcome by altering the epigenetic control of VDR. In our analysis we considered three molecules, sulforaphane, curcumin, and butyrate produced by the intestinal microbioma, which if added to the diet could enhance the expression of VDR through epigenetic mechanisms, facilitating the transcription of the VDR gene and the activity of this transcriptional factor.
Natural Epigenetic Modulators of Vitamin D Receptor
Vitamin D plays an important role in every tissue due to its differentiating properties and the control of calcium homeostasis. The reversion of the epigenetic repression of the vitamin D receptor (VDR) could lead to an increased sensitivity of the cells to the beneficial activity of the hormone...
www.mdpi.com
Vitamin D resistance can be inherited or de novo acquired; in the former case is caused by the mutation of VDR or RXR genes or the genes involved in calcitriol activation, catabolism, and signaling, in the latter case the resistance can be environment-dependent.
Sulforaphane(brocolli extract)
Because VDR is regulated by epigenetic mechanisms, it would be interesting to carry out a clinical study testing the enhancement of vitamin D efficacy in patients treated with SF. The evidences supporting the hypothesis that SF could be beneficial in incrementing the response to vitamin D are provided by the study of Schwab et al. [88], investigating the anti-inflammatory effect of SF on three different human colorectal cancer cells.Curcumin
Probiotics and Butyrate
The resistance to vitamin D could be overcome by altering the epigenetic control of VDR. In our analysis we considered three molecules, sulforaphane, curcumin, and butyrate produced by the intestinal microbioma, which if added to the diet could enhance the expression of VDR through epigenetic mechanisms, facilitating the transcription of the VDR gene and the activity of this transcriptional factor.
Interesting that retinoic acid(Retin-a) does work to an extent but again what was their vitamin d3 status? I've seen one video claim _90%_ of the world is deficient in vitamin d3.
So if you are supplementing with vitamin d3 also try topical retinoic acid or add sulforaphane, curcumin or butyrate producing probiotics into the mix.
Abnormal VDR protein
Some VDR gene mutations can cause the production of an abnormally short VDR protein, or an abnormal receptor that can't bind to calcitriol, RXR, or DNA.
The retinoid X receptor (RXR) is involved in the nuclear signaling pathways for both retinoic acid and vitamin D. The use of all-trans-retinoic acid (ATRA) or 1,25-dihydroxyvitamin D3 (1,25D) as a differentiation therapy may be a promising treatment for AML.
Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia.
Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months
So if you are supplementing with vitamin d3 also try topical retinoic acid or add sulforaphane, curcumin or butyrate producing probiotics into the mix.
Abnormal VDR protein
Some VDR gene mutations can cause the production of an abnormally short VDR protein, or an abnormal receptor that can't bind to calcitriol, RXR, or DNA.
The retinoid X receptor (RXR) is involved in the nuclear signaling pathways for both retinoic acid and vitamin D. The use of all-trans-retinoic acid (ATRA) or 1,25-dihydroxyvitamin D3 (1,25D) as a differentiation therapy may be a promising treatment for AML.
Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia.
Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months
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Butyrate and vitamin D can have synergistic effects on vitamin D receptor (VDR) expression, which can help with disease resistance and may be a potential antibiotic alternative:
If you're taking a vitamin D supplement but aren't seeing improvement, you can try adding a synergistic component like butyrate to help with absorption.
Or maybe even GABA(gamma amino butyric acid) taken sublingually or orally?
However, emerging evidence has demonstrated that changes in both circulating and brain levels of GABA are associated with changes in gut microbiota composition and that changes in GABA levels and microbiota composition play a role in modulating mental health. This recent research has raised the possibility that GABA may be a potent mediator of the gut–brain axis. This review article will cover up-to-date information about GABA-producing microorganisms isolated from human gut and food sources, explanation why those microorganisms produce GABA, food factors inducing gut–GABA production, evidence suggesting GABA as a mediator linking between gut microbiota and mental health, including anxiety, depression, stress, epilepsy, autism spectrum disorder, and attention deficit hyperactivity disorder, and novel information regarding homocarnosine-a predominant brain peptide that is a putative downstream mediator of GABA in regulating brain functions.
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Butyrate and vitamin D can have synergistic effects on vitamin D receptor (VDR) expression, which can help with disease resistance and may be a potential antibiotic alternative:
- VDR expression
Butyrate and vitamin D can increase VDR mRNA expression in intestinal epithelial cells infected with Salmonella.
- Disease resistance
Butyrate and vitamin D can help make poultry more resistant to disease.
- Antibiotic alternative
Butyrate and vitamin D may be a cost-effective alternative to antibiotics for preventing and controlling diseases.
- Anti-inflammatory
Butyrate and vitamin D can reduce inflammation and the severity of Salmonella colitis.
- Antimicrobial peptides
Butyrate and vitamin D can increase the production of antimicrobial peptides.
If you're taking a vitamin D supplement but aren't seeing improvement, you can try adding a synergistic component like butyrate to help with absorption.
Or maybe even GABA(gamma amino butyric acid) taken sublingually or orally?
However, emerging evidence has demonstrated that changes in both circulating and brain levels of GABA are associated with changes in gut microbiota composition and that changes in GABA levels and microbiota composition play a role in modulating mental health. This recent research has raised the possibility that GABA may be a potent mediator of the gut–brain axis. This review article will cover up-to-date information about GABA-producing microorganisms isolated from human gut and food sources, explanation why those microorganisms produce GABA, food factors inducing gut–GABA production, evidence suggesting GABA as a mediator linking between gut microbiota and mental health, including anxiety, depression, stress, epilepsy, autism spectrum disorder, and attention deficit hyperactivity disorder, and novel information regarding homocarnosine-a predominant brain peptide that is a putative downstream mediator of GABA in regulating brain functions.
Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D3 - clinical implications for cardiovascular diseases
This effect accounts for the reduction of oxidative/
nitroxidative stress and the overall increase in bioavailable
NO – both a highly beneficial effect of vitamin D3 treatment
on endothelium and the cardiovascular system.
The process of restoring bioavailable NO production by vitamin D3 is
more efficient and comprehensive than other possible path-
ways of the restoration of dysfunctional endothelium, like
elevated levels of L-arginine, sepiapterin treatment, scav-
enging or dismutase of O2
−. As shown here, L-arginine, sepiapterin or NADPH inhibition can only partially restore
(20%–30%) endothelial function under physiologically
acceptable concentrations
The effect of vitamin D supplementation on the progression of benign prostatic hyperplasia: A randomized controlled trial
The intervention group received 50 000 units of vitamin D3 and the control group received a placebo every two weeks for six months.
BPH is associated with chronic inflammation and increased expressions of pro-inflammatory cytokines such as interleukin-15 [8] in stromal cells, interleukin-17 in T cells [9], interferon-gamma in basal cells and stromal cells, and IL-8 cells in growth factor-derived epithelial cells [10].
"It has been reported that a 6000 IU dose red(TYPO-per) day of Vitamin D analogs can reduce the prostate volume in BPH patients [17,26]."
Conclusion
In this study, we evaluated the effect of vitamin D supplementation on prostate volume, PSA levels, and patients’ symptoms according to the IPSS questionnaire. We found that vitamin D supplementation significantly reduced prostate volume and serum PSA levels in the intervention group compared to the control group. This effect was independent of age and the presence or absence of diabetes. Both groups had a reduction in clinical symptoms after the end of the study.Cannabidiol (CBD) Upregulates Vitamin D3 Receptors (VDRs) Expression That Modulates Cytokines (TNF-α, IL-6), Tissue Elasticity, Cellular Senescence, and Mitochondrial ATP Generation in Human and Rodent Cell Lines
Conclusion
Our data clearly show that CBD significantly increased VDR expression in human and rodent cell lines. CBD treatment also exerts anti-inflammatory effect, improved tissue elasticity, anti-senescence activity, and enhanced mitochondrial activity. In this study, for the first time, we showed the evidence suggesting that the VDR plays a critical and multifaceted role in various types of human cells.Hair Regrowth with Cannabidiol (CBD)-rich Hemp Extract –A Case Series
Menopause and estrogen deficiency are associated with apparent intestinal resistance to vitamin D, which can be reversed by estrogen replacement
Discussion
In this study, we have assessed not only the effect of aging on steroid hormone interaction in vivo but also the significance of changing estrogens levels on the bioresponse of vitamin D receptors in vitro. By using a ovariectomized model, we have simulated postmenopausal osteoporosis and by using an aging model we have assessed the effect of age-related bone loss in this interaction as well.There is evidence to suggest that estrogens regulate the activity and expression of VDR in target organs