Hair Follicle Primordiums - Is 2020 The Year Where It All Ends?

[Marcaronii]

I mostly agree but i really think (and hope) the rich guys among us will get their hands on this treatment in 2021. If I m right informed the infrastructure to make this available is built up parallel to the trials. Which shows their confidence!

I'm not rich but I'll find a way to get this no matter what. That's how much I want my hair back. Balding is a horrible disease that fucks with someone emotionally on so many levels.

 

[Heinrich Harrer]

I'm not rich but I'll find a way to get this no matter what. That's how much I want my hair back. Balding is a horrible disease that fucks with someone emotionally on so many levels.

So, what are we stealing?

 

[disfiguredyoungman]

I'm not rich but I'll find a way to get this no matter what. That's how much I want my hair back. Balding is a horrible disease that fucks with someone emotionally on so many levels.

Same here, my dad gets 230k from his insurance and I will BEG him for a loan if Tsuji ever delivers.

 

[H]

So, what are we stealing?

If you guys need a 3rd man ive watched The Town a couple times.

 

[disfiguredyoungman]

I’d be so down for a bald bank robbery with you guys to get my hair back, even if it meant that I had to listen to Heinrich’s frantic psychobabble 24/7 while he shoots people in the back.

 

[byebyehair]

So, what are we stealing?

I heard rumors this stuff is valuable.
It belongs to some old lady in england.

 

[Heinrich Harrer]

I’d be so down for a bald bank robbery with you guys to get my hair back, even if it meant that I had to listen to Heinrich’s frantic psychobabble 24/7 while he shoots people in the back.

Make sure you glue your wig beforehand tho, once inside the bank we’ll have to move fast.

 

[disfiguredyoungman]

Make sure you glue your wig beforehand tho, once inside the bank we’ll have to move fast.

No toup gets left behind shall be our credo.

 

[Robert Robertson]

"Painstaking research began with the bioengineering of various types of hair-follicle germs, which were grafted onto bald mice. The germs carried tiny nylon guides to nudge the growing hairs in the right direction.

Once that proved successful, the team moved on to bioengineering human hair-follicle germs and transplanting them in mice.

The human hairs grew in 21 days with the correct shafts, inner root sheaths and surrounding cells that normal human hair would, the study said.

Further tests proved the human hairs were, indeed, human."

Sources:
https://www.nature.com/articles/ncomms1784
https://www.thestar.com/news/world/...ese_scientists_regrow_human_hair_in_mice.html

Thank you kindly!

Does anyone else here feel like even in a 'best case scenario', where their safety trials succeed and human clinical trials succeed, you would still wait 5 years before going through with it just in case? Personally, I trust the US FDA and would wait for them to clear it before I would proceed in that scenario.

 

[byebyehair]

Thank you kindly!

Does anyone else here feel like even in a 'best case scenario', where their safety trials succeed and human clinical trials succeed, you would still wait 5 years before going through with it just in case? Personally, I trust the US FDA and would wait for them to clear it before I would proceed in that scenario.

If you wait for FDA you wait way longer than 5 years in a best case scenario.

 

[iamgotham]

Thank you kindly!

Does anyone else here feel like even in a 'best case scenario', where their safety trials succeed and human clinical trials succeed, you would still wait 5 years before going through with it just in case? Personally, I trust the US FDA and would wait for them to clear it before I would proceed in that scenario.

Nah, I would be a pioneer!

 

[Francesco17]

So as some of you know Riken will start human trials next year, for the HF Primordiums treatment, developed by Dr. Takashi Tsuji.

This new treatment is probably our best chance for a cure in the next following years, however nothing is guaranteed since nobody knows if the treatment will work in humans. Unfortunately we already saw several treatments working in mice, that failed when applied to humans.

I made this thread, for the community to start discussing the possibility of a 2020 release date, and to share new updates regarding Riken's treatment.

So, do you believe in a 2020 release date (in Japan)? Are you optimistic about this new approach?

(sorry for the bad English, but is not my native language)

--

View attachment 100483

June 4th, 2018

Problems and solutions for clinical application to humans

There were two major challenges to applying hair follicle regeneration technology to humans. 1) The need to develop an in vitro amplification method for epithelial stem cells and dermal papilla cells Previously, epithelial stem cells had not been identified, and it was known that the hair follicle regenerative capacity of cells disappears while cultured in vitro. However, we have overcome these problems with mouse and human cells after research activities over 7 years. 2) The development of a robust method for the mass production of regenerated hair follicles Conventionally, regenerated hair follicles were produced manually by compartmentalizing two types of stem cells into a collagen gel at a high density in a cell suspension of ten thousandth of a milliliter. Therefore, it was very difficult to stably mass-produce regenerated hair follicles, and we needed to develop a new technology to overcome this for the clinical application. We succeeded in developing this technology with collaborative research with Kyocera Corporation, which began in 2016. With the success of these developments and by overcoming the other challenges to carrying out clinical research, we have advanced to the P0 stage (preclinical testing) in RIKEN Program for Drug Discovery and Medical Technology Platforms. Based on this program, RIKEN is playing a role in the preclinical research and academic validation of the amplification and cultivation technology of human cells. Organ Technologies, Inc. will establish the manufacturing and quality-control system for conducting the preclinical tests. Kyocera will provide novel methos for manufacturing regenerated hair follicles.

Schedule

Under the plan, we will begin manufacturing samples for preclinical tests in July 2018 and we will conduct preclinical safety tests using animals. We plan to complete the safety testing in 2018. If the results of the preclinical safety tests are successful, we will apply for clinical research to the Certified Special Committee or Certified Committee for Regenerative Medicine. After receiving approval from the Committee, we will present a provisional plan to the Minister of Health, Labor and Welfare, and will shift toward implementation of clinical research. The details of the clinical research will be announced before the initiation of the research.

The problem, I believe, is cost. Self transplant is already a reality that will work for most, effectively and without serious side effects.

However, it costs more than what the average person could be easily spend at a stage of their life where it really matters.

Now, stunning new technologies will no doubt be developed in the coming years, but for a long time they will reserved for the few able to afford them, even more so than is the case for self transplants currently

 

[Armando Jose]

The germs carried tiny nylon guides to nudge the growing hairs in the right direction

This is a big problem, the direction of hair shaft, Maybe nylon can help.

 

[Hair ball]

There is maybe a problem for those of us with very curly hair...
F*@k!

 

[Joxy]

Is this something that will help scientists to maintain dermal papilla gene inductivity?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788059/

 

[Grasshüpfer]

So they have

• Created mouse follicles in the lab out of epithelial and mesenchymal cells that together grew a hair. ✓
• Created human follicles in the lab. ✓
• Implanted them on mice. ✓
• Found a way to grow mesenchymal cells in the lab. ✓
• Found a way to grow epithelial cells in the lab (actually a big deal for regrowing body parts in the future.) ✓
• Found a way to create human follicles in a way to allow mass production out of the two cell types. ✓
• Implanted those in mice ✓

Now what they still have to do:

• Implant the hair in humans
• Scale up the growing of both cell types
• Scale up the mass production of the hair follices.
• Figure out problems with yield ect.

And the third thing I'm worried about. This usually takes a few years.
Even if you have the method you have to design the machines and factory and keep testing them because scaling always causes things to stop working and you have to figure out what's wrong.
You get issues in yield of follicles and so on.


So while I guess we might hear awesome news in 2020 2021, until it comes out there will be a few more years.

 

[KevinMcElwee]

So they have

• Created mouse follicles in the lab out of epithelial and mesenchymal cells that together grew a hair. ✓
• Created human follicles in the lab. ✓
• Implanted them on mice. ✓
• Found a way to grow mesenchymal cells in the lab. ✓
• Found a way to grow epithelial cells in the lab (actually a big deal for regrowing body parts in the future.) ✓
• Found a way to create human follicles in a way to allow mass production out of the two cell types. ✓
• Implanted those in mice ✓

Now what they still have to do:

• Implant the hair in humans
• Scale up the growing of both cell types
• Scale up the mass production of the hair follices.
• Figure out problems with yield ect.

And the third thing I'm worried about. This usually takes a few years.
Even if you have the method you have to design the machines and factory and keep testing them because scaling always causes things to stop working and you have to figure out what's wrong.
You get issues in yield of follicles and so on.


So while I guess we might hear awesome news in 2020 2021, until it comes out there will be a few more years.

RIKEN has the plan to bring it to the market in 2020 and Kyocera announced it too. I think they have thought about release date extensively so I hope Tsuji is right.

 

[Hate da Bt]

So while I guess we might hear awesome news in 2020 2021, until it comes out there will be a few more years.

I agree.
I think 2025-2030 seems more realistic.

 

[KevinMcElwee]

I agree.
I think 2025-2030 seems more realistic.

WOUld you mind to read the announcement in which an aimed release date in 2020 is definitely mentioned? Or do you want to wait 12 years until it comes out?

 

[disfiguredyoungman]

WOUld you mind to read the announcement in which an aimed release date in 2020 is definitely mentioned? Or do you want to wait 12 years until it comes out?

I fear he might be right, even in the best case scenario release doesn’t equal wide distribution with economies of scale. It seems unlikely for them to service a vast amount of people in 2020... I still hope for a miracle though.