It's the major player in angiogenesis.
Could be. I like the idea, but I'm focusing on intense wounding.
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- Thread starter pegasus2
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It's the major player in angiogenesis.
Could be. I like the idea, but I'm focusing on intense wounding.
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I have gotten very good results with a roller especially related to autophagy of scar tissue for which it is wondrous.
damn man. That progress is wild, keep it up.
What do we think about the incremental cost/benefit of applying your regrowth topical twice daily vs. only once?
Twice daily is obviously better, but for lifestyle and compliance factors if I'm being honest with myself I have a better shot at sticking with once a day.
Is there any science around that question or could it be as simple as once daily you will get 50% of the regrowth results as twice daily?
What do we think about the incremental cost/benefit of applying your regrowth topical twice daily vs. only once?
Twice daily is obviously better, but for lifestyle and compliance factors if I'm being honest with myself I have a better shot at sticking with once a day.
Is there any science around that question or could it be as simple as once daily you will get 50% of the regrowth results as twice daily?
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I don't think that it is actually that clear whether such meds need to be taken so that there is always some in the blood stream. This doesn't seem to matter in HRT related to external effects for MtFs, meaning the chicks on pills taken once a day do just as well as the chicks on the patch which is steady state. Now, Peg is using things that might not react like hormones but the half-life question is one that I bring up often on MtF boards because so many on there assume that it matters to "results".
Some meds like estrogel can be stored in fat reserves and then released gradually making it hard to use "too much" I wonder whether constant application of a topical hormone throughout the day might be necessary even beyond half-life. It could be that spikes or peak levels matter more in terms of "results" or it could be that lower levels that don't go past a certain serum level work best but generally, I don't think we know with any precision.
Some meds like estrogel can be stored in fat reserves and then released gradually making it hard to use "too much" I wonder whether constant application of a topical hormone throughout the day might be necessary even beyond half-life. It could be that spikes or peak levels matter more in terms of "results" or it could be that lower levels that don't go past a certain serum level work best but generally, I don't think we know with any precision.
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Some of the compounds have no need to be applied twice a day, but others have shorter half-lives. If you are use them once a day then use a higher concentration than you otherwise would. 2% minoxidil twice a day gives about the same results as 5% minoxidil once a day. I don't think it's critical to use anything here twice a day except maybe BIM-I for the first six days after wounding, and even that would probably be ok. Alternatively you could use erlotinib which has a longer half-life and would definitely be ok with once daily applications.
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Even if variable blood concentration didn't matter in terms of estrogenic transcriptional effects, blood levels that spike and fall are less effective at suppressing LH than steady levels, and therefore more androgens will be produced as a consequence unless another LH antagonist such as a GnRH analog is used concomitantly.
The reason why pills and patches have similar suppression of androgens (although effectively you need a higher dose on pills for the same LH reduction) is because patches tend to give much lower levels. Oral pills also give lower levels like patches, and provide similarly consistent levels, the drawback being higher estrone relative to estradiol. Estrone has a significantly longer half-life compared to estradiol.
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What are your thoughts on using topical otc estrogen creams? (as described in a previous thread you shared by IdealForehead)
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My thoughts are that four more big fat tubes of Estrogel arrived today from Thailand, $115 shipped 10 days or less.
Low concentrations so you need to use a lot of it, but they are good.
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I've put in an order for some compounds through Wuhan HHD. How long did it take you to receive your order from China?
Also, what's the best source for DMSO to use in the vehicle?
Also, what's the best source for DMSO to use in the vehicle?
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What will be your regimen now, what you adding? I am thinking of starting CB, estriol, SW, PGE2, Eplerenone, TM (don't want insomnia though), and maybe WAY+CHIR if finances allow. Since I couldn't understand the papers well I still need to reread them before I decide on SAG, is BIM-I useful if it is used without SAG? As you mentioned it prevents epidermal differentiation. Still trying to wrap my head around these lol. @pegasus2
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I'm not going to be changing up much. Right now, topically I'm using generic minoxidil liquid with RU and crushed up finasteride tablets dissolved and a separate otc estriol cream. I think this probably had really poor absorption, so I'm going to be changing to making my own topical solution with ethanol, PG, and DSMO, a higher percentage of minoxidil (7% to 10% probably), RU, dutasteride (at a much higher dose than my shitty finasteride solution), and estriol. I expect this new topical to function better if for no other reason than it has better absorption. All these above compounds were purchased from China on Alibaba, so hopefully they will arrive soon. I'll also be swapping out my over the counter retinol cream for a prescription strength tretinoin cream, once that arrives from India.
I've been seeing modest results on my current regimen, so I'm going to wait a few months before changing things up too much to see how well this will work.
If I'm not happy with regrowth in a few months, I'll consider adding more topicals (Dinoprost/bimatoprost and SW look like top contenders) or using exogenous E2 instead of E3
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Glad to hear you are seeing results from this, happy for you man. I am sure that added duta and dmso will do your hair good. I know I asked this a couple weeks back but have you seen improvements since adding estriol, wondering if there is a powder form we could get?
Also, this is prob in another threat but do we know if topical finasteride actually helps? I realize that oral finasteride Doesnt block as much dht in the scalp compared to serum, but if topical worked as derek mentioned by disproportionately reducing dht, we wouldnt need oral? Can it actually reduce serum dht by more than 70%, if not then there is no possible harm of adding it to oral.
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Does that mean in terms of level of effectiveness topical dutasteride > topical finasteride > oral dutasteride> oral finasteride? If we’re talking about suppressing scalp dht
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I wish I knew, both go systemic but some users do report less sides from topicals. In terms of potency in scalp dht suppression it seems ideally you would want to block as much as possible orally and add a topical on top of that to clean up whatever is left as there is higher 5AR enzyme density in the scalp. Studies comparing topical to oral were not great so its hard to draw conclusions from what I have seen. If you can take oral, then take oral, this way you know for sure it will be getting to every HF in the scalp whereas with topical you may have poor permeability or coverage.
What I am more interested in is whether adding topical will cause any additional sides, finasteride can only inhibit 70%. Even if you add both, it will only inhibit up to 70% of serum dht. Does that mean that you will not get any additional risk of sides by adding a topical? Or are there other factors that contribute to sides other than lower DHT levels? Doctors do prescribe 0.5mg for less sides and same efficacy as it suppresses very similar amount.
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In terms of effectiveness, if you were only choosing as a monotherapy without factoring in sides... oral>topical. I think just about everyone on this forum would agree with that.
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It does seem like topical AA and oral AA would work best in a synergistic type way. Since you’re attacking scalp dht from angles. I just thought since there was a study showing topical finasteride doing more against scalp dht than oral finasteride then maybe topical properly applied really is more effective by itself compared to oral by itself.
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I thought so too, but wasn’t there a study showing topical finasteride does more against scalp dht compared to oral? Maybe it’s not as consistent at stopping scalp dht? Maybe that’s why overall it’s not as effective
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Im not aware. From my understanding, the current studies are unreliable. The thing is once you go topical there exists user error. From oral, its hard to make an error. Not to mention the convenience of oral that everyone enjoys.
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Right, my plan would be to just use both and hope sides don’t affect me too much.