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In the Beginning of 2023
HMI-115 PRLR antibody: The Most Promising Treatment Ever
- Thread starter pegasus2
- Start date
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Phase I Study of the Prolactin Receptor Antagonist LFA102 in Metastatic Breast and Castration-Resistant Prostate Cancer - PMC
Despite evidence for a role for prolactin signaling in breast and prostate tumorigenesis, a prolactin receptor-binding monoclonal antibody has not produced clinical efficacy. Increased serum prolactin levels may be a biomarker for prolactin receptor ...
www.ncbi.nlm.nih.gov
here is what we could expect from side effects. The only annoying one I have to say is the fact it increases prolactin serum.
Del is a trash antibody and LFA isn't a while lot better. Neither one mimics the PRLR knockout phenotype in mice, only HMI-115 does. LFA greatly increases serum prolactin, but for some reason HMI does not. At least not at the doses tested. Perhaps it doesn't cross the bbb while LFA does?Phase I Study of the Prolactin Receptor Antagonist LFA102 in Metastatic Breast and Castration-Resistant Prostate Cancer - PMC
Despite evidence for a role for prolactin signaling in breast and prostate tumorigenesis, a prolactin receptor-binding monoclonal antibody has not produced clinical efficacy. Increased serum prolactin levels may be a biomarker for prolactin receptor ...
here is what we could expect from side effects. The only annoying one I have to say is the fact it increases prolactin serum.
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If less prolactin is bound in PRLRs it makes sense it could cascade into more serum Prolactin tho? (like 5ARIs and Testosterone)
In any case I imagine its negligible enough to not matter
In any case I imagine its negligible enough to not matter
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More serum prolactin will make you less horny.
Glad to see we're full circle again.
I don't care tho. Will probably use p5p or caber in that case
Glad to see we're full circle again.
I don't care tho. Will probably use p5p or caber in that case
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I don't understand your post and I think you do not understand the MOA of HMI
Prolactin isn’t a trash hormone, that might even be worse scenario
Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European Male Aging Study (EMAS) - PubMed
Low PRL is related to several metabolic, psychological, and sexual unhealthy characteristics in European men. Checking PRL might be useful to stratify men for cardiovascular risk and to encourage appropriate lifestyle changes.
pubmed.ncbi.nlm.nih.gov
As I have said before, the side effect profile in men will be really interesting to see, they really need to be make it topical or reduce the profile to HF receptors
Not quite. UT has mechanisms independent of PRLR. Also it can affect the brain if the drug doesn't cross the bbb. HMI-115 is not shown to increase serum prolactin significantly so I don't know why it's being discussed.
All I can say is I'm glad you're not in charge of the FDA. We wouldn't have any approved drugs. You can Google anything and find a reason to be afraid of it. In reality every expert is not concerned about blocking every prolactin receptor.Prolactin isn’t a trash hormone, that might even be worse scenario
Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European Male Aging Study (EMAS) - PubMed
Low PRL is related to several metabolic, psychological, and sexual unhealthy characteristics in European men. Checking PRL might be useful to stratify men for cardiovascular risk and to encourage appropriate lifestyle changes.
As I have said before, the side effect profile in men will be really interesting to see, they really need to be make it topical or reduce the profile to HF receptors
There is zero chance that HMI-115 will ever be a topical treatment. It might not even work as a topical treatment. Macrophages carry their own prolactin receptors and modulate the HF. If HMI works through modulating the hair cycle altering activity of macrophages then topical HMI wouldn't work
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Again, the important hormones including prolactin are produced inside hair pilosebaceous unit, ..., then altering its levels in blood is worst than best and you dont regain hair loss.
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Don't you mean understatement? Overstatement implies that highly unlikely is an exaggeration. Understatement would mean that Pegasus is "under" estimating the improbability of his claim.
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SO, it's over?
Not people experiencing hairloss in 10 or more years…probably
For us yeah
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The wait is slowly killing me inside, only solution to buy time for HMI results is hair transplant or join pegasus rat lab, but im going with the first one because at least it is a guaranteed result
yeah kintor canceled HMI after multiple deaths in the trial
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I knew It. f*** Bayer
Where is this info from? Deaths from what?
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Definition of SARCASM
a sharp and often satirical or ironic utterance designed to cut or give pain; a mode of satirical wit depending for its effect on bitter, caustic, and often ironic language that is usually directed against an individual; the use or language of sarcasm… See the full definition
www.merriam-webster.com
several people in the trial who died came forward and told us
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