Having a drug, that is extremely expensive to produce. You can either push on a trial for one illness where having a treatment will be covered by health insurance everywhere and therefore it will be easy to get back the investment or you will go for illness where you will get even bashed, that is not a real issue, is nowhere covered by health insurance and because of the production costs are high you wont be able to sell that large amount + you still have a risk of a failure in trial. And on top of that the patent expiration is doing tick tock. What do you choose?