Information On Rch-01, Tsuji, Follica And Brotzu

[Kagaho]

Also, to entertain the idea is pitiful. Why wouldn't he just post to a website such as Folliclethought once? Instead, he rather repeat himself to a bunch of forum users; then call it "helpful".

As if his cliche username doesn't convey it all.

I think he is onto something, but like i said i cant be sure.

But suggesting a website like Folliclethought to publish this kind of info its laughable.

Lets wait till october.

 

[hanginginthewire]

I don’t handle my emotions too good but I still have a working brain.

 

[Kagaho]

I don’t handle my emotions too good but I still have a working brain.

well prove it doing something helpful for the community and stop the meaningless whinning.

Its really annoying for most of us

 

[hanginginthewire]

The community is beyond help. That’s why we’re here.

 

[CrownBalding]

Do you believe rch-01 is going to be a significantly better treatment than finasteride+minoxidil? Many studies show how well fina worked in regrowth but a lot of us here beg to differ...

 

[Kagaho]

@Insider , do you know something about the current state of relationship between Shiseido and Replicel.

I remember a beef regarding the non-compliance of the realization of phase 2 by Replicel.

That could affect commercialisation somehow?

 

[CrownBalding]

Earlier you said finasteride would not be of benefit after rich-01. How can we know for sure that rch has the same long term maintenance as fina? Can you elaborate on that on that answer?

 

[Kagaho]

Shiseido is not informing replicel on the states of the trial. But when they have the results they must share them with replicel (it is in the contract). That is believed to be one of the reasons why it takes so long for shiseido to make the results public.

Thats what i was afraid of. Replicel is definitely not a serious company.

 

[Kagaho]

This was the theory. To see if that is true long term results of phase 2 needs to be evaluated.

Fina reduces dht levels in the scalp (unfortunatly in the whole system). RCH-01 makes the hair follicle resistant to dht. So if the follicle is immune to dht reducing the dht level is no benefit. Only long time studies with serveral injections can show if the follicle really become immune.

Totally agree. Immunity and resistance are not the same thing. It will require a big, costly long term trial to prove immunization against DHT, i hope shiseido plans are to continue research for at least 5 more years.

But even a small sample follow up can help to provide valuable data.

 

[Feelsbadman.jpg]

I' am in a network of scientific advisors in the field of hairregeneration. Here i present you all information I was able to gather on the new treatments that are about to come out in the next 2 years. Excuse my english i m not a nativ speaker.

RCH-01:
Results from phase 2 Study. 17% regrowth and 85% of tested person responded above 10% regrowth.
The results will be published 1st october and the treatment will be available starting february 2019 (only in japan). The plan is offer the treatment in china in 2020 as well.

Tsuji:
The new study with mice is on shedule and the results so far look as expected. A new anouncment wont be made till march 2019 when they start human trials.

Follica:
The results of phase 2 weren't good enough to risk the money on a phase 3 trial. If the product development is continued or not depends on the optimisation trial.

Brotzu:
The Brotzu lotion is released mid october. It is less effective than minoxidil and finasteride together and for user who allready use minoxidil and finasteride wont get a benefit of the lotion. (In the board there were no clear decission in the past if the product should be released or not. Because some were against the release due to little effectivness. But the company had to pay fees to the inventor so that they needed to make a decision fast and they decided now to release the product.)

I am going to LARP that this guys is not LARPing.

RCH-01 is progressing exactly as intended. Not surprised at all. This, along w/ Tsuji are the only treatments that really matter imo.

Some questions about RCH-01 dosing for the phase II w/ Shiseido.

Were all the subjects male?

How many injections were administered?

What was the frequency/time interval between injections?




These results are similar to the phase I which held up even after 5 years for the most part (the slight decrease to me looks like it could be within normal hair cycle fluctuations).

 

[Feelsbadman.jpg]

Totally agree. Immunity and resistance are not the same thing. It will require a big, costly long term trial to prove immunization against DHT, i hope shiseido plans are to continue research for at least 5 more years.

But even a small sample follow up can help to provide valuable data.

This is impossible to prove as this will differ from one individual to the next. RCH-01 can only give your Androgenetic Alopecia hair the DHT resistance that your donor hair has which will vary from individual to individual. Some people thin in the donor area too, especially into old age. So if your donor region was genetically susceptible to start balding in your 70s, then your RCH-01 treated hair would suffer the same fate since it's the same cell line.

IMO, donor hair is not immune to DHT in anyone. It is just highly resistant and this resistance can vary. Given a long enough time line and high enough exposure to DHT, donor hair will also begin to experience the same adverse effects that hairs in the Androgenetic Alopecia region undergo. Similarly, given the presence of DHT, all men will eventually get prostate cancer. The ones that don't just happen to die from something else first.

So, people asking/thinking finasteride won't help after RCH-01. Does finasteride thicken hair in the donor(I believe it does and many hair transplant surgeons would affirm to this)? Why would it not? If yes, then finasteride will still help after RCH-01 however, you would probably die before you would actually see the benefit. If people lived for centuries, then I think finasteride would be a must along w/ RCH-01 in order maintain a full head.

 

[jamesbooker1975]

Can't believe people is still talking about Brotzu.

 

[Kagaho]

This is impossible to prove as this will differ from one individual to the next. RCH-01 can only give your Androgenetic Alopecia hair the DHT resistance that your donor hair has which will vary from individual to individual. Some people thin in the donor area too, especially into old age. So if your donor region was genetically susceptible to start balding in your 70s, then your RCH-01 treated hair would suffer the same fate since it's the same cell line.

IMO, donor hair is not immune to DHT in anyone. It is just highly resistant and this resistance can vary. Given a long enough time line and high enough exposure to DHT, donor hair will also begin to experience the same adverse effects that hairs in the Androgenetic Alopecia region undergo. Similarly, given the presence of DHT, all men will eventually get prostate cancer. The ones that don't just happen to die from something else first.

So, people asking/thinking finasteride won't help after RCH-01. Does finasteride thicken hair in the donor(I believe it does and many hair transplant surgeons would affirm to this)? Why would it not? If yes, then finasteride will still help after RCH-01 however, you would probably die before you would actually see the benefit. If people lived for centuries, then I think finasteride would be a must along w/ RCH-01 in order maintain a full head.

I agree to a certain extent.

I think you are being rather "purist" with your definition of immunization.

I was referring more to achieving the maximum degree of resistance you can given your genetics.

That will be revolutionary in itself

And it shouldnt be less than 8-10 years even for the most androgen sensitive cases.

 

[CrownBalding]

I agree to a certain extent.

I think you are being rather "purist" with your definition of immunization.

I was referring more to achieving the maximum degree of resistance you can given your genetics.

That will be revolutionary in itself

And it shouldnt be less than 8-10 years even for the most androgen sensitive cases.

Why shouldn’t it be less than 8-10 years? How do we know the effects of rch doesn’t last more than 5 years?

 

[Kagaho]

Why shouldn’t it be less than 8-10 years? How do we know the effects of rch doesn’t last more than 5 years?

Transplanted hair stays at least 10 years even if you have strong baldness genes.

IF RCH-01 give us the same degree of "immunity" than hair transplants it should last that long

 

[champpy]

@Insider
This is a long shot, but do you have any info on the injection pattern of RCH-01?
Does each injection cover a specific surface area of the scalp?
Im guessing one treatment would require multiple injection sites.
Thanks
Edit: you may have already answered above. Sorry man

 

[CrownBalding]

How much time did it take for results to be seen?

 

[Kagaho]

This is no insider information this is my own idea based on my knowledge.

Since rch-01 is reactivating follicle that are allready damaged by DHT and the cells merge to the hair follicle to increase it length I belive that rch-01 is increasing the resistance against dht and is reparing the already done damage. If that is true injections in the whole scalp should be performed in an intervall of severall years. And then there would be definitly no need for fina anymore.

Yeah, thats what i think too.

I think it was Hoffman who said he expected to reach "implanted cell dominance" after a set of injections spaced during months or years

 

[Rock12]

This is no insider information this is my own idea based on my knowledge.

Since rch-01 is reactivating follicle that are allready damaged by DHT and the cells merge to the hair follicle to increase it length I belive that rch-01 is increasing the resistance against dht and is reparing the already done damage. If that is true injections in the whole scalp should be performed in an intervall of severall years. And then there would be definitly no need for fina anymore.

So what would prevent this from increasing the resistance against dht in other parts of the body ? Do you have any info on systematic effects of the injections ?

 

[Btg]

So what would prevent this from increasing the resistance against dht in other parts of the body ? Do you have any info on systematic effects of the injections ?

arent they cells from the follicle ? i dont think they can migrate to a different tissue .