LMFAO at thinking Minoxidil cross the blood brain barrier
BiL0giEy
"Absorption and Metabolism Minoxidil is at least 90% absorbed from the GI tract in experimental animals and man. Plasma levels of the parent drug reach maximum within the first hour and decline rapidly thereafter. The average plasma half-life in man is 4.2 hours. Approximately 90% of the administered drug is metabolized, predominantly by conjugation with glucuronic acid at the N-oxide position in the pyrimidine ring, but also by conversion to more polar products. Known metabolites exert much less pharmacologic effect than minoxidil itself; all are excreted principally in the urine.
Minoxidil does not bind to plasma proteins and does not cross the blood brain barrier. , and it its renal clearance corresponds to the glomerular filtration rate. In the absence of functional renal tissue, minoxidil and its metabolites can be removed by hemodialysis."
Source : DEPARTMENT OF HEALTH AND HUMAN SERVICES
https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2015/018154Orig1s026ltr.pdf
What is the Blood Brain Barrier ? ==>
https://en.wikipedia.org/wiki/Blood–brain_barrier
You would be f*****g dead if it did cross it
When you smell a fart, there's no actual sh*t that goes into your brain