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- 213
Italian Hair Loss Lotion To Hit The Market In 2016
- Thread starter paleocapa89
- Start date
People saying, that a lotion targeted at females is a marketing strategy? Lmfao
They could have created a lotion marketed at all target groups, but seperating them creates more validation. Genetic alopecia affecting both genders differently is not rocket science. What i wonder about though, is how much effectiveness the lotion may have lost (?) to bring it to the market as a cosmetic product.
Nonethless, the thing im most glad about is them showing results from proper trials, thats what matters the most. To be honest, if this ends up as a truly valid product, it will be another case in medicinal history were a solution to a problem is found by accident. It's crazy how true this is with so many products, hope everything work out well for us.
They could have created a lotion marketed at all target groups, but seperating them creates more validation. Genetic alopecia affecting both genders differently is not rocket science. What i wonder about though, is how much effectiveness the lotion may have lost (?) to bring it to the market as a cosmetic product.
Nonethless, the thing im most glad about is them showing results from proper trials, thats what matters the most. To be honest, if this ends up as a truly valid product, it will be another case in medicinal history were a solution to a problem is found by accident. It's crazy how true this is with so many products, hope everything work out well for us.
- Reaction score
- 475
The question is which one is more effective.
Will be the irony of the year when it comes out and the ones who hated on it the most will be one of the first to probably order it lmfao. Pathetic bunch
- Reaction score
- 475
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- 1,242
University of Naples → Napples → APPLES!
- Reaction score
- 520
trump is going to crash the new world order, so i see no chances for apples anymore.
- Reaction score
- 1,623
beps63 posted this 1 hour ago on BelliCapelli. This seems the abstract of the scientific research which will be presented/introduced at SITRI's next month. The participation of Brotzu (and probably FIDIA too) was confirmed by my dermatologist on the thread, who is the president of SITRI's association.
Translation: (by me with the help of Google)
Abstract Naples 14/4/18
'Liposomal solution containing DGLA, Equol and Carnitine for the treatment of androgenetic alopecia.'
G.Brotzu, G. Brotzu, F. Consolaro, C. Secchieri.
Bioricerca snc, Fidia Farmaceuticici SPA,
Presents Giovanni Brotzu
In 2012 KITAGAWA e coll. showed that cationic liposomes, with a diameter of around 100 nm, could easily penetrate through the dermis and thereby improving the release of lipophilic molecules. Based on this research, it was studied if it was possible to use liposomes for the release of molecules able to stimulate endothelial cells of the hair bulbs. Previously it was observed that PGE1 was able to stimulate endothelial cells and to increase tissue capillarization.
It is known that di-homo-gamma-linoleic acid (DGLA) is the biochemical precursor of PGE1. In fact it is transformed by cyclooxygenase into PGE1. It has been ascertained that in the various forms of alopecia there is a diminished capillarization and therefore, a deficit in the functionality of the capillaries which supply the hair bulbs of both O2 and the other molecules.
The other molecules transported by liposomes are: the Equol and the Carnitine.
The Equol is a flavonoid that inhibits the 5α-reductase enzyme by preventing testosterone from turning into dihydrotestosterone; carnitine promotes the beta-oxidation of the circulating lipid chains and increases the local metabolism.
Dihydrotestosterone is one of the main culprits of Androgenetic Alopecia.
Tests performed: the efficacy of two liposomal lotions was tested on 30 male subjects and 30 female subjects. The following checks were performed: efficacy against hair loss by results of phototrichogram and wash test, evaluation of hair resistance by Pull Test, clinical evaluation of tolerability and subjective evaluation of the effectiveness and tolerability of the lotion. Tests were performed at the beginning of treatment (T0) and after 1 (T1), 3 (T3) and 6 (T6) months of treatment.
The results showed that a daily and constant application of the above mentioned lotion favors the growth of new hair and reduce the fall of existing hair. In addition, the hair becomes more resistant and the lotion is well tolerated by the subjects.
Sorry for eventual grammar errors. I would like to say that we know that Equol does NOT inhibit 5AR but binds to DHT itself, so please don't make boring comments stating that, also because in a month we could possibly know everything.
There are other things I wanted to say more, but right know that the congress is confirmed, I guess writing tons of lines here is kinda useless.
Translation: (by me with the help of Google)
Abstract Naples 14/4/18
'Liposomal solution containing DGLA, Equol and Carnitine for the treatment of androgenetic alopecia.'
G.Brotzu, G. Brotzu, F. Consolaro, C. Secchieri.
Bioricerca snc, Fidia Farmaceuticici SPA,
Presents Giovanni Brotzu
In 2012 KITAGAWA e coll. showed that cationic liposomes, with a diameter of around 100 nm, could easily penetrate through the dermis and thereby improving the release of lipophilic molecules. Based on this research, it was studied if it was possible to use liposomes for the release of molecules able to stimulate endothelial cells of the hair bulbs. Previously it was observed that PGE1 was able to stimulate endothelial cells and to increase tissue capillarization.
It is known that di-homo-gamma-linoleic acid (DGLA) is the biochemical precursor of PGE1. In fact it is transformed by cyclooxygenase into PGE1. It has been ascertained that in the various forms of alopecia there is a diminished capillarization and therefore, a deficit in the functionality of the capillaries which supply the hair bulbs of both O2 and the other molecules.
The other molecules transported by liposomes are: the Equol and the Carnitine.
The Equol is a flavonoid that inhibits the 5α-reductase enzyme by preventing testosterone from turning into dihydrotestosterone; carnitine promotes the beta-oxidation of the circulating lipid chains and increases the local metabolism.
Dihydrotestosterone is one of the main culprits of Androgenetic Alopecia.
Tests performed: the efficacy of two liposomal lotions was tested on 30 male subjects and 30 female subjects. The following checks were performed: efficacy against hair loss by results of phototrichogram and wash test, evaluation of hair resistance by Pull Test, clinical evaluation of tolerability and subjective evaluation of the effectiveness and tolerability of the lotion. Tests were performed at the beginning of treatment (T0) and after 1 (T1), 3 (T3) and 6 (T6) months of treatment.
The results showed that a daily and constant application of the above mentioned lotion favors the growth of new hair and reduce the fall of existing hair. In addition, the hair becomes more resistant and the lotion is well tolerated by the subjects.
Sorry for eventual grammar errors. I would like to say that we know that Equol does NOT inhibit 5AR but binds to DHT itself, so please don't make boring comments stating that, also because in a month we could possibly know everything.
There are other things I wanted to say more, but right know that the congress is confirmed, I guess writing tons of lines here is kinda useless.
- Reaction score
- 198
I think It depends of how much the shedding is reduced, and how much regrowth we obtain; so we can then label the treatment as a "complement" or a "pillar treatment".
Lets not forget that finasteride could be described the same way: pills to reduce the hair loss, and regrowth a bit.
The only thing that bothers me, is that they say that equol attaches to/blocks alfa reductase, instead of DHT. I think that difference is crucial, not only for the effectiveness, but also to avoid sides...
I also think that the three ingredients create a good sinergy.
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- 1,401
That’s what finasterise does... attaches to alpha reductase to prevent T from turning into DHT. It’s the same thing...
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- 520
I wouldn't call this inconclusive because this study shows it works, but the question is to what degree. Yeah, it favors growth of new hair and reduces fall of existing hair but for that I can already use a weak keto shampoo. Very vague study in my opinion
- Reaction score
- 4,609
that doesnt really say anything ?