Kintor has started Phase 3 trial in China for Pyrilutamide

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Modill

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badnewsbearer said:
so your claim is that both CB and pyrilutamide have sexual side effects associated with them? I mean with pyrilutamide I am inclined to believe you because there is no proper mechanism that would prevent this form happening. with CB I am not sure, the molecules properties are so that once it hits the bloodstream it gets converted to a cortisol like molecule that itself has no anti androgenic properties. that is why it was hyped and the only reason it wasn't at some point is because it was not that effective against hair loss after 12 months. basically this would mean all the studies are inherently untrustworthy and fake and the design of the molecule is flawed.

on a different note, if you got sides on pyr after 5 weeks the only way I can explain this is that there was some accumulation. because otherwise you'd probably get them almost immediately because the anti androgen acts within hours. it makes no sense to have libido on a fixed concentration of the drug and 5 weeks later no libido on the same concentration. normally even for finasteride side appear within the first 3-4 weeks.

so if there was accumulation it can be of the metabolite only because pyrilutamide itself has a short half life and saturation would have happened much faster. if it is the metabolite I suppose you can either reduce the dose or use it for 4 weeks, then stop 3-4 days. this will not ruin your hair but it will give your body enough time to clear out the metabolite enough so that further accumulation should not cause any problems. maybe using 2.5% alternating once and twice a day. that would yield a 2/3rd reduction in pyrilutamide and metabolites in the blood. at a certain dose accumulation to the extent where it becomes a problem will not be possible because the body also gets rid of the drug and an equliibrium is reached.

I think the difference between anti androgens and finasteride really is that lowered dosing actually makes a difference. with finasteride if you use 1/4th you still get basically the same effect. with pyrilutamide you get probably 1/4th of the effect but also probably far less side effects. studies have shown that 2.5% does at least something so it might be worth trying. maybe combined with an equally low dose of CB because they do work different not in terms of action but in terms of metabolism and side effects and so they might not add up side wise but efficacy wise they might.

so to sum up id try low dose CB and low dose pyrilutamide because I think it makes sense playing with dosing as opposed to finasteride dosing which always nukes DHT by at least 30-40% no matter the dose
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Hi @badnewsbearer ,

I know well what the CB study states: it says that it regenerates the hair very well during the first year and then it stops working, and that it does not produce side effects because as you say, CB disintegrates quickly in the blood.

And I tell you that if that were true, everyone could stop taking the terrible poison that is finasteride FOR 1 YEAR, recover their erections and their hair, no? But the truth is that I don't know any story, neither here nor in the Spanish forum https://foro.recuperarelpelo.com

I'm not saying the study is wrong, I'm saying what I see.

Changing the subject, you say I could leave Pyri 4 days every 4 weeks, but the study says it takes 19 days for the metabolism to clear. Pyri works great for hair, I'm going to use less and give it a try.

Are you trying Pyri or CB? Or are you going to start testing? What do you plan to do?

Regards

Translated with www.DeepL.com/Translator (free version)
 
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badnewsbearer

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kiwi666 said:
I got nothing for you but I wish you luck.

You’re being dim. But I think you’re probably just a mad and sad individual. So it’s understandable.

There are other factors I don’t see you taking into account. Which is at odds with your “thorough” discourse.

We don’t know if what modill is using is pure / EXACTLY the same as what they made in their own labs. We don’t know by a long shot if he’s using the same doses - despite him trying his best. We don’t know if the vehicle is the same. We don’t know if he has the equipment to get dosing exactly right.

Despite your research and knowledge there’s no way to compare controlled million dollar lab results with our back yard chemistry.
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well then that means just even more so that we cannot determine that a particular drug has side effects based upon online reports. experiementation is for us to find out what can work without having to wait years until the Pharma company gets something going(in the case of CB, phase 2 trials where done in 2019 and it was said it would be on the shelves in 2021) sure covid hit but they are just under miserable management. Kintor is doing better but I do not trust them to be honest because of other supsicious reports about them and because a trial like this could be easily manipulated. also the sample size and duration of the trial was far too short. Cassiopea did a lot better on that front.

maybe in 3 years or so we can get real pyrilutamide. until then the only guidance to whether it works or not should be the phase 3 clinical trial with a bigger sample size that will complete in July. it should be hundreds of people on the high dosage. however their problem is that they have marketed pyrilutamide as a sexual side effect free finasteride replacement. so what if someone gets sexual sides in their trial? it seems to me that it would be very much in their interest to hide this in some shady statistics and cover it up. after all otherwise their drug is just a much more inconvenient and far less proven finasteride analogue and would probably not be very popular. why apply a creme twice a day with no long term studies when you can pop a pill that provenly works very well if both cause sexual side effects. makes no sense. so it would be quite a business failure for them if this turns out to be this way. this is why I have my suspicion about the accuracy of their reporting. it is not reviewed by western scientists. of course they are also currently doing a phase 2 safety trial in the US and this will be much more interesting when they need to let the FDA review it. while the FDA is not an angel organization it is much better than the Chinese variant. they'd certainly be able to pick up poor mythology or tinkering with the samples etc.
 
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badnewsbearer

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Modill said:
Hi @badnewsbearer ,

I know well what the CB study states: it says that it regenerates the hair very well during the first year and then it stops working, and that it does not produce side effects because as you say, CB disintegrates quickly in the blood.

And I tell you that if that were true, everyone could stop taking the terrible poison that is finasteride FOR 1 YEAR, recover their erections and their hair, no? But the truth is that I don't know any story, neither here nor in the Spanish forum https://foro.recuperarelpelo.com

I'm not saying the study is wrong, I'm saying what I see.

Changing the subject, you say I could leave Pyri 4 days every 4 weeks, but the study says it takes 19 days for the metabolism to clear. Pyri works great for hair, I'm going to use less and give it a try.

Are you trying Pyri or CB? Or are you going to start testing? What do you plan to do?

Regards

Translated with www.DeepL.com/Translator (free version)
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it does not say that it stops working, we do not know how the curve will go after the 12 months, it could be stable after that and provide further maintenance. it would make no sense to just lose efficacy because it clearly is getting to the dermal papilla and thus has some rather potent anti androgenic activity even after 6 months. I do not know any story either but not because of side effects but lack of efficacy. and it would be odd if the drug is both, ineffective but also causes sexual sides. if it has not enough anti androgenic action where it is applied it has even less potency in other parts of the body like the penis.

yes it might take longer for the metabolite to clear but you do not need full clearance, apparently it is enough to stay under a certain level, otherwise you would have gotten sides after days and not 6 weeks. it took 6 weeks either for some process in your body to get kicked off or for the drug to accumulate. if it is the latter the only solution is experimentation.

I am currently not trying either of them. I am trying a low dose of topical finasteride. but if that does not work due to sides or lack of efficacy I will probably try pyrilutamide. I am not too excited about it however. most likely I will need to shave my head because there will be no other good opportunities
 
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badnewsbearer

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Modill said:
Yesterday I had my líbido back at 95%. I applied 0,5ml of pyri with gloves for not to touch it, and now bye bye libido and morning erection again.

Kintor is the biggest liar, more so than Merk.
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so your side took 6 weeks to show up then you stopped and they went away. and now you say the appeared after just a day of 1/4th of the dose? something cannot be right. it either takes so long to cause sides or not. I think your personal anecdotes are of no value at this point it just makes no sense
 
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Ralph Wiggum

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Modill said:
Yesterday I had my líbido back at 95%. I applied 0,5ml of pyri with gloves for not to touch it, and now bye bye libido and morning erection again.

Kintor is the biggest liar, more so than Merk.
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www.merriam-webster.com

Definition of PSYCHOSOMATIC

of, relating to, concerned with, or involving both mind and body; of, relating to, involving, or concerned with bodily symptoms caused by mental or emotional disturbance… See the full definition
www.merriam-webster.com www.merriam-webster.com
 
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Hope111

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I myself left it with my girlfriend with whom I had normal relations at the age of 27, having been on Finasteride for 9 years. Seeing that I was losing a little hair, I read about Finasteride on the Internet again and there I found out that there were people who had dysfunction. After a few days with another girl she didn't get up and that relationship went to sh*t because of that.
I'm sorry to get out of the thread, but it is clear that everything adds up. Lower the level of androgens, the passing of the years and suggestion.
But it is true that nobody here knows what is going on in the body of "modil" or perhaps his mind or both. I myself, who am still on Finasteride, do not know if I am impotent by suggestion or by Finasteride
 
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Modill

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badnewsbearer said:
so your side took 6 weeks to show up then you stopped and they went away. and now you say the appeared after just a day of 1/4th of the dose? something cannot be right. it either takes so long to cause sides or not. I think your personal anecdotes are of no value at this point it just makes no sense
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It is what it is.
I am reading the experience of plenty of people trying pyri and all of them have side effects. There is none that does not have.

But I wish it didn't give me side effects. But the truth is that yesterday morning I used 0.5ml of pyri, and at night after peeing I already dropped a few drops after peeing (like when I took finasteride). I can assure you 100% that nothing that happens to me is psychosomatic.
 
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Gonalgique

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4 weeks and I apply it once a day.
I take another drug called amitriptyline for psynchosomatic pain.
At the moment, i don't shed but I have an high Norwood scale (So maybe no more hair to shed).
I have maybe vellus hair growing but i'm not sure.
I buy it from actifolic.
 
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Ralph Wiggum

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Modill said:
It is what it is.
I am reading the experience of plenty of people trying pyri and all of them have side effects. There is none that does not have.

But I wish it didn't give me side effects. But the truth is that yesterday morning I used 0.5ml of pyri, and at night after peeing I already dropped a few drops after peeing (like when I took finasteride). I can assure you 100% that nothing that happens to me is psychosomatic.
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No sides for me using it once a day for about a month or so. Got it from MinoxidilMax.
 
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Gonalgique

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Gonalgique said:
4 weeks and I apply it once a day.
I take another drug called amitriptyline for psynchosomatic pain.
At the moment, i don't shed but I have an high Norwood scale (So maybe no more hair to shed).
I have maybe vellus hair growing but i'm not sure.
I buy it from actifolic.
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I give Piry a shot because, i believe that i'm dht sensitive. Since my teenage, I have pimples and since i start balding, they pop on my scalp.
 
kiwi666

kiwi666

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Who gives a f*** if it’s psychosomatic or a chemical reaction if you can’t get your dick up - that’s a reason to experiment.

Balding blog posts weekly pics now of people growing their hair back micro needling with finasteride and minoxidil - and sometimes just micro needling and minoxidil.
 
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Modill

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Very happy to hear that there are people who have no side effects. But you have only been trying it a short time. Let's see if in 2 months you are well, it would be fantastic.

@FerBecken what do you mean with no results? Are you still suffering shedding as before starting with pyri?
 
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