Kintor has started Phase 3 trial in China for Pyrilutamide

[badnewsbearer]

It is what it is.
I am reading the experience of plenty of people trying pyri and all of them have side effects. There is none that does not have.

But I wish it didn't give me side effects. But the truth is that yesterday morning I used 0.5ml of pyri, and at night after peeing I already dropped a few drops after peeing (like when I took finasteride). I can assure you 100% that nothing that happens to me is psychosomatic.

and that is the best indicator that either you are not using pyrilutamide or are all gotten insane. because it can totally be the case that pyrilutamide causes sides however they must be rare otherwise they would have shown up in the study. I dont think it is remotely plausible that 80% of users who got it from the china lab have sides and nobody in the study while suing the same product. they could not hide this from regulators in the US. remember nobody had sexual sides in the studies neither in the 5% twice daily or any other group. nobody. and here its almost everybody and intense ones as well? cant be quite right.

also everybody has different sides. one day you say you get them after 6 weeks because of accumulation, next day you put in half the dose with gloves and libido is lost that makes no sense biologically. other users have sides all over the place, headaches, mood disorders, severe sexual sides, none of them recorded in the studies and seem to be different in every users. why on earth e.g would it cause headaches. why would it cause loss of libido 1 day after applying when before you could do it 6 weeks. for example with finasteride I get sides on the exact same day +-1. I never got them suddenly at a completely different point in time. either your body can deal with lower androgens or it cant. we are not talking about years progressing where the body itself has different physiology. we talk about a month

i have read about the overwhelming negative reports regarding pyrilutamide. it seems as if every person has some issue or swears it is not effective. then the question becomes how can it be so anti androgenic when so many think its not even working?


I think you are completely psychosomatic. you are applying a FRACTION of the dose and get "immediate sexual dysfunction" when before just by pure magic your body could tolerate the same load of androgens for 6 weeks. you also said pyrilutamide almost killed you

 

[badnewsbearer]

Very happy to hear that there are people who have no side effects. But you have only been trying it a short time. Let's see if in 2 months you are well, it would be fantastic.

@FerBecken what do you mean with no results? Are you still suffering shedding as before starting with pyri?

but dont sides appear after one application with gloves? btw everybody here is using half of the dose from the studies

 

[FerBecken]

Very happy to hear that there are people who have no side effects. But you have only been trying it a short time. Let's see if in 2 months you are well, it would be fantastic.

@FerBecken what do you mean with no results? Are you still suffering shedding as before starting with pyri?

My hairloss is not aggressive. I'm NW2 and I apply it on the temples and frontal area, which has been thinning for years. Nothing has changed: no increase in shedding, no reduction in hairloss, no regrowth, no nothing. I'm using pyri as monotherapy. Have never used finasteride or minoxidil.

 

[FerBecken]

but dont sides appear after one application with gloves? btw everybody here is using half of the dose from the studies

In my case I'm actually using one of the doses tested in the study (5mg QD). Just not the one with the best results.

 

[Modill]

and that is the best indicator that either you are not using pyrilutamide or are all gotten insane. because it can totally be the case that pyrilutamide causes sides however they must be rare otherwise they would have shown up in the study. I dont think it is remotely plausible that 80% of users who got it from the china lab have sides and nobody in the study while suing the same product. they could not hide this from regulators in the US. remember nobody had sexual sides in the studies neither in the 5% twice daily or any other group. nobody. and here its almost everybody and intense ones as well? cant be quite right.

also everybody has different sides. one day you say you get them after 6 weeks because of accumulation, next day you put in half the dose with gloves and libido is lost that makes no sense biologically. other users have sides all over the place, headaches, mood disorders, severe sexual sides, none of them recorded in the studies and seem to be different in every users. why on earth e.g would it cause headaches. why would it cause loss of libido 1 day after applying when before you could do it 6 weeks. for example with finasteride I get sides on the exact same day +-1. I never got them suddenly at a completely different point in time. either your body can deal with lower androgens or it cant. we are not talking about years progressing where the body itself has different physiology. we talk about a month

i have read about the overwhelming negative reports regarding pyrilutamide. it seems as if every person has some issue or swears it is not effective. then the question becomes how can it be so anti androgenic when so many think its not even working?


I think you are completely psychosomatic. you are applying a FRACTION of the dose and get "immediate sexual dysfunction" when before just by pure magic your body could tolerate the same load of androgens for 6 weeks. you also said pyrilutamide almost killed you

You can believe what you want. The forums are full of people who say that Finasteride does not cause side effects and that people who suffer from Post Finasteride Syndrome are psychological and that Finasteride does not cause side effects. I tell you what happens in my body, and you should thank the people who comment on their experience and not call people crazy.

As for why I am affected so much now by a single application? I don't know, I guess because Pyri takes 19 days to leave the body and my body is very sensitive. For your information, very little hair falls out, almost none, and the last application was 3 days ago and 0.5ml. That makes me think that it takes a long time to metabolize the compound, because my shedding is always a lot.

As for it almost killing me, when I noticed lack of libido and erectil disfunction at 6 weeks, I was also super tired, slept a lot, couldn't work, I was taking a nap everyday when I never take naps, didn't feel hungry, and was very unmotivated. I couldn’t going to the gym because I was super super tired, just wanted to sleep, when I usually go 3 or 4 times a day, and I run 30 min also 3-4 times a day.

You keep thinking it's psychological and keep attacking those of us who are experiencing it.

Cheers

 

[Jack Ito]

You can believe what you want. The forums are full of people who say that Finasteride does not cause side effects and that people who suffer from Post Finasteride Syndrome are psychological and that Finasteride does not cause side effects. I tell you what happens in my body, and you should thank the people who comment on their experience and not call people crazy.

As for why I am affected so much now by a single application? I don't know, I guess because Pyri takes 19 days to leave the body and my body is very sensitive. For your information, very little hair falls out, almost none, and the last application was 3 days ago and 0.5ml. That makes me think that it takes a long time to metabolize the compound, because my shedding is always a lot.

As for it almost killing me, when I noticed lack of libido and erectil disfunction at 6 weeks, I was also super tired, slept a lot, couldn't work, I was taking a nap everyday when I never take naps, didn't feel hungry, and was very unmotivated. I couldn’t going to the gym because I was super super tired, just wanted to sleep, when I usually go 3 or 4 times a day, and I run 30 min also 3-4 times a day.

You keep thinking it's psychological and keep attacking those of us who are experiencing it.

Cheers

What so you’re telling me you have a total of 6-8 fitness sessions a day? 4 runs and 4 gym sessions.. come off it pal and stop talking sh*t

 

[Modill]

What so you’re telling me you have a total of 6-8 fitness sessions a day? 4 runs and 4 gym sessions.. come off it pal and stop talking sh*t

No, the same day I go to the gym 45 min, after gym I go to run another 30 min. In total I train 3 days per week, 1 hour and 15 min.
Best

 

[baldingisthedevilscurse]

No, the same day I go to the gym 45 min, after gym I go to run another 30 min. In total I train 3 days per week, 1 hour and 15 min.
Best

do you do dermarolling?

 

[Modill]

do you do dermarolling?

I did at the beginning, the first week. Then I stopped

 

[badnewsbearer]

pyr taking 19 days to leave the body is completely inaccurate and that is recorded in pharmacological studies. the metabolite has very low anti androgenic potency and in this concentration probably cant do much

 

[Modill]

pyr taking 19 days to leave the body is completely inaccurate and that is recorded in pharmacological studies. the metabolite has very low anti androgenic potency and in this concentration probably cant do much

I know, Pyri 2 days, but its metabolite 19 days.

Man, I am the most affected by this situation. I hate being bald. Finasteride gives me erectile dysfunction. I had all my hopes in Pyri. Imagine how happy I was for 6 weeks to see how my hair grew and my libido was unaffected, and then all of a sudden BOOM! Same situation as finasteride. What I can do? Tell me something positive. The truth is I can’t understand tue results of Kintor's study, I feel very angry.

 

[RU serious]

I know, Pyri 2 days, but its metabolite 19 days.

Man, I am the most affected by this situation. I hate being bald. Finasteride gives me erectile dysfunction. I had all my hopes in Pyri. Imagine how happy I was for 6 weeks to see how my hair grew and my libido was unaffected, and then all of a sudden BOOM! Same situation as finasteride. What I can do? Tell me something positive. The truth is I can’t understand tue results of Kintor's study, I feel very angry.

I got screwed by finasteride, couldn't handle it at all. Like literally got permanent gyno from a tiny dose over a couple months.

I'm on 2.5mg Pyri a day, noticed some mild anti-androgenic sides like ball ache at a higher dose so I tapered it down. But generally seem to be handling it OK.

 

[badnewsbearer]

I know, Pyri 2 days, but its metabolite 19 days.

Man, I am the most affected by this situation. I hate being bald. Finasteride gives me erectile dysfunction. I had all my hopes in Pyri. Imagine how happy I was for 6 weeks to see how my hair grew and my libido was unaffected, and then all of a sudden BOOM! Same situation as finasteride. What I can do? Tell me something positive. The truth is I can’t understand tue results of Kintor's study, I feel very angry.

I mean just lower the dose. if it took 6 weeks to accumulate to an extent it tipped off on a lower dose hair growth can still be achieved but with even slower accumulation. at some dose you won't reach a certain threshold because of the half life. then no further accumulation will occur.

however it might not be due to the accumulation of the drug at all. in my opinion with most drugs with a half life like this, accumulation should be achieved much sooner than 6 weeks.

in finasteride microdosing studies have shown that a small dose of 0.04% topical applied finasteride reduces DHT by 35% as opposed to 60% with the tablet. some people claim that no matter the dose you will eventually get the same DHT reduction however they would be wrong. it has been shown that after just 2 weeks, serum DHT reduction plateaued and no further accumulation of finasteride in blood was detected. so we know that this is the maximum impact finasteride will have on DHT.

however, some people get side effects many weeks after the maximum reduction has been reached. for example just 3 pills of finasteride are enough to reach this plaque yet most people dont get sides after 3 days but rather many weeks even months. why is that? there must be some slow acting mechanisms in the body that only slowly turn on once the hormonal changes take place. like increased aromatization or something.

i find this quite odd that someone can be fine with 30% DHT and higher estrogen for weeks and suddenly their body would not function anymore sexually or mentally. yet this is the case. In my case I get sides with oral finasteride after exactly 2 weeks +_2 days. yet my DHT is reduced by 70% after just 4 days. however at that point my libido is unaffected. why? I do not know either. some say its due to higher T and then later this is converted to estrogen however this makes no sense, why would the T not be converted to E in the first 2 weeks? it might have something to do with gene expression slowly changing or something who knows.

however, in contrast to finasteride on pyrilutamid a lower dose can make sense as the dose effect curve is probably more linear and not exponential as it is with finasteride.

 

[Left4bald]

Sorry for you man... i'm feel sad for you with this sh*t (hairloss). Maybe with a very low dose of pyri and not combine with cb, it would works. For all of us, there is also hair transplant but.. Stay strong

 

[badnewsbearer]

maybe combination of low dose CB, topical liposomal finasteride and pyrilutamide can work as they all work different and synergistically and might not add up in terms of sides as they have different metabolites.

 

[Modill]

I got screwed by finasteride, couldn't handle it at all. Like literally got permanent gyno from a tiny dose over a couple months.

I'm on 2.5mg Pyri a day, noticed some mild anti-androgenic sides like ball ache at a higher dose so I tapered it down. But generally seem to be handling it OK.

I am happy you can use 0,25% per day. How long have you been using it?

 

[Modill]

maybe combination of low dose CB, topical liposomal finasteride and pyrilutamide can work as they all work different and synergistically and might not add up in terms of sides as they have different metabolites.

I wonder if any batch of Actifolic has more than the specified amount, although I don't think so, because it would be more expensive for them.

The truth is that I doubt very much that at this point, a pharmaceutical company would lie so much with some results. Would they have used a different vehicle?

It would be interesting to find a laboratory that could measure our blood pyri levels to know if we have the same levels as shown by Kintor in the study, or on the contrary we are doing something wrong and we have much more than the study claims. Does anyone know how this is done?

Thank you,

 

[HansMetjen]

Is that Chinese laboratory legit?

"Sabrina" and Jumpman @ Discord claim so, but how do we know that they don't sell rat poison?

 

[Modill]

Is that Chinese laboratory legit?

"Sabrina" and Jumpman @ Discord claim so, but how do we know that they don't sell rat poison?

Actifolic? I think they are from Netherlands

 

[HansMetjen]

Actifolic? I think they are from Netherlands

No, that Chinese lab from the Discord Group Buys. It's located in Wuhan.