Kintor new AR degrader w/o side effects

[Micky_007]

I should reformulate, not absorption but deliver to the target cells. sure you can absorb more by doing various things, using warm water on the skin before to provide better vascularisation, needling etc. but what happens when you have an androgen receptor degrader and then you needle and open the micro vasculature, it goes directly into the blood stream, then the androgen receptors in your brain, heart or penis will also get degraded which is pretty problematic, more so than finasteride even. in their description they talk about localized deliver and that it stays in tissue for many days and that in animal models systemic activity was very low but they never talk about the technique that assures this. after all Kintor has been in attention recently for exaggerating effects of drugs without proper evidence. but I guess we will see as it is in phase 1 clinical trials rn and if it does have systemic action we will most certainly find out except if chines men are not reliant on androgens

I agree that systemic absorbtion would obviously be a problem. And so far all we have as to why the drug won't go systemic from the company is "just trust me bro" - which obviously isn't enough for most people, especially for the many who have seen topicals in the past say it won't go systemic, only to find out the hard way that it does go systemic.

I'm excited as everyone at the speed Kintor is moving but I am keeping my eye out for how exactly it won't go systemic.

We've seen FDA trials even like Finasteride do "seemingly well" only for it to be the most controversial hairloss drug in terms of its actual safety.

 

[RolfLeeBuckler]

when will this fuc..cking phase II data ever released ?!?!

 

[Micky_007]

when will this fuc..cking phase II data ever released ?!?!

By the end of this year.

 

[RolfLeeBuckler]

By
By the end of this year.

which is now…
How do you know? Where Did Kintor mentioned that they will release By the end of this Year?

 

[poopfeast420]

which is now…
How do you know? Where Did Kintor mentioned that they will release By the end of this Year?

Jan 14 dermatology conference

 

[trialAcc]

when will this fuc..cking phase II data ever released ?!?!

Who cares, they already greenlit phase 3. You will see the results before it is approved lol

 

[Micky_007]

which is now…
How do you know? Where Did Kintor mentioned that they will release By the end of this Year?

No, as in by December 31st. Thats more than 2 weeks from now.

I've seen it in multiple posts by Kintor, that's how I know. I don't have the time to find the links.

 

[trialAcc]

where did you see kintor get approved by fda for phase 3?

Phase 3 was greenlit in China where phase 2 was actually completed (and the results they are waiting on in here). Phase 2 in the USA will start in early 2022.

 

[John Difool]

Kintor's KX-826 Pyrilutamide Meets Goal In Phase 2 Trial - Follicle Thought

Kintor Pharmaceutical of China brings us some timely good news today regarding its lead candidate drug KX-826 for the treatment of androgenetic alopecia. Phase 3 Will Be Soon A well respected company in the hair growth industry, Kintor Pharmaceutical, continues to outpace the competition. In a...

www.folliclethought.com

This is the thread everyone is trying to interpret here, some with more success than others apparently.

 

[RolfLeeBuckler]

Kintor's KX-826 Pyrilutamide Meets Goal In Phase 2 Trial - Follicle Thought

Kintor Pharmaceutical of China brings us some timely good news today regarding its lead candidate drug KX-826 for the treatment of androgenetic alopecia. Phase 3 Will Be Soon A well respected company in the hair growth industry, Kintor Pharmaceutical, continues to outpace the competition. In a...

www.folliclethought.com

This is the thread everyone is trying to interpret here, some with more success than others apparently.

the biggest mistake you Can do in this hairloss industry is to Trust folliclethought.com .
He is such a big liar like Youngjet or Tsuji

 

[John Difool]

I don't care about their opinion. I read the press releases. They just summarized what's out there. You seem to have a problem with everything Kintor. Just take a deep breath and relax. Things will be happening eventually and soon enough with the Chineses. People speculate on what's coming up, so what? No big deal. The world will still continue to exist with your bald scalp or not.

 

[fashy]

Some of the users on this forum need to chill the f*** out. What are you frantically panicking about and coming in here, and wreaking havoc and whining on various posts all the time for? We all know as much as you know. When there's any news about Kintor, everyone on this forum is going to know the second they are released. Stop coming in here and f*****g whining all the time about how this or that company missed some arbitrary deadline and just wait patiently like the rest of us.

Kintor or anyone else ain't coming with news just because some autist on hairlosstalk decided to leave angry messages today because he didn't get what he wanted on time. If you're gonna seethe every single day at least do so privately and don't sour everyone else's day with your annoying presence on the forum.

 

[poopfeast420]

the biggest mistake you Can do in this hairloss industry is to Trust folliclethought.com .
He is such a big liar like Youngjet or Tsuji

Folliclethought puts out a ton of exclusive interviews, you dont know what you're talking about.

 

[Micky_007]

Folliclethought puts out a ton of exclusive interviews, you dont know what you're talking about.

Exactly. He is a good source of information who always links the source.

Blaming the admin of Follicle Thought and Youngjet for the incompetency of a company like Tsuji's to meet their own targets and lack of communication is crazy. They simply passed on the message they got from the horses mouth.

 

[RolfLeeBuckler]

Folliclethought puts out a ton of exclusive interviews, you dont know what you're talking about.

for example his TissUse/j hewitt Story was veeeery exciting. „J hewitt starts hair cloning trial in end of 2019“

Furthermore the dates of the Shiseido RCH-01 Market launch were interesting. „Shiseido will commercialize in Q4 2018“
„Shiseido will commercialize in Q2 2019“
„Shiseido will commercialize until end of 2019“
„Shiseido will commercialize in 2020“

- very nice making those claims and playing with the hopes of hairloss sufferers. Je could start in the Team of Takashi Tsuji. I am sure je would Collect a lot of money For the sh*t je writes

 

[Micky_007]

for example his TissUse/j hewitt Story was veeeery exciting. „J hewitt starts hair cloning trial in end of 2019“

Furthermore the dates of the Shiseido RCH-01 Market launch were interesting. „Shiseido will commercialize in Q4 2018“
„Shiseido will commercialize in Q2 2019“
„Shiseido will commercialize until end of 2019“
„Shiseido will commercialize in 2020“

- very nice making those claims and playing with the hopes of hairloss sufferers. Je could start in the Team of Takashi Tsuji. I am sure je would Collect a lot of money For the sh*t je writes

Dude.

He posts what these companies disclose to him. They give their expected timelines and information and he simply shares it with the public. Without his website most people wouldn't know about half the stuff in the pipeline.

I repeat, it's not his fault that the companies didn't keep to their initial targets. He is doing a favor to people by getting information.

 

[RolfLeeBuckler]

Dude.

He posts what these companies disclose to him. They give their expected timelines and information and he simply shares it with the public. Without his website most people wouldn't know about half the stuff in the pipeline.

I repeat, it's not his fault that the companies didn't keep to their initial targets. He is doing a favor to people by getting information.

Shiseido Never gave any timeline For commercilaizing RCH-01.
Maybe Lee Buckler said that they would commercialize in end of 2018.
But the 2019 Dates or the 2020 Release Date was NEVER communicated of Shiseido or lee Buckler. It was a date setted by folliclethought.com to attract the readers of his blog that they Come again and again to his site.

the thing with J Hewitt was the strangest thing. He Stucks under a blanket with Jon Knight, a man which is maybe not existing. The story that he finds No Cell processing center because all clinics in Japan Are loyal to Shiseido is laughable and sad. They Both folliclethought and Jon Knight wanted to make a Big story out of These sh*t SHT-Technology TissUse wanted to get rid of.
It Just was a Big SCAM

 

[Micky_007]

Shiseido Never gave any timeline For commercilaizing RCH-01.
Maybe Lee Buckler said that they would commercialize in end of 2018.
But the 2019 Dates or the 2020 Release Date was NEVER communicated of Shiseido or lee Buckler. It was a date setted by folliclethought.com to attract the readers of his blog that they Come again and again to his site.

the thing with J Hewitt was the strangest thing. He Stucks under a blanket with Jon Knight, a man which is maybe not existing. The story that he finds No Cell processing center because all clinics in Japan Are loyal to Shiseido is laughable and sad. They Both folliclethought and Jon Knight wanted to make a Big story out of These sh*t SHT-Technology TissUse wanted to get rid of.
It Just was a Big SCAM

LOL this is just funny because Follicle Thought admin repeatedly says the dates are his estimated predictions based on the information given. People ASK constantly for dates and it is for that reason he created that table of treatments in the pipeline with their estimated dates on the Ultimate Guide to Hair Regeneration 2021. He mentions it always in the comments section that there's no guarantee on timelines but it's best to stay hopeful.

Looking for people to blame is silly. You're an adult and you should know that no one knows an exact date for anything in the hairloss pipeline. He puts an ESTIMATED timeline in his table so that readers can have a visual idea of his predictions based on the current stage of progress per company and any feedback he gets from the companies + he factors in approximately how long each trial should take (whilst still giving some leeway) , so that he doesn't cut it too early.

He is not there to create click bait.

I literally see nothing wrong with him putting up predictions. Literally most people on this forum post about what their timeline predictions are for treatment in the hairloss pipeline.

There's many different hairloss websites which do similar, as well as hair articles on the internet + on YouTube. Trying to put the blame on Follicle Thought admin when he is simply trying to help people get a visual idea of the progress and possible end dates is retarded especially if you're thinking Follicle Thought admin conspired with Jon Knight.

Again, lack of progress or failure from any hairloss company has nothing to do with Follicle Thought.

He also states explicitly multiple times "estimated". Can't you read?

 

[clarence-forgotpassword]

LOL this is just funny because Follicle Thought admin repeatedly says the dates are his estimated predictions based on the information given. People ASK constantly for dates and it is for that reason he created that table of treatments in the pipeline with their estimated dates on the Ultimate Guide to Hair Regeneration 2021. He mentions it always in the comments section that there's no guarantee on timelines but it's best to stay hopeful.

Looking for people to blame is silly. You're an adult and you should know that no one knows an exact date for anything in the hairloss pipeline. He puts an ESTIMATED timeline in his table so that readers can have a visual idea of his predictions based on the current stage of progress per company and any feedback he gets from the companies + he factors in approximately how long each trial should take (whilst still giving some leeway) , so that he doesn't cut it too early.

If the only source is the companies' own claims, that's not an estimate. That's just hype. You are a retard. I mean, according to these claims, Follica would've been out 2017, Replicel/Shiseido 2018, Fuji/Riken 2020, and let's not say anything about Histogen...

 

[Micky_007]

If the only source is the companies' own claims, that's not an estimate. That's just hype. You are a retard. I mean, according to these claims, Follica would've been out 2017, Replicel/Shiseido 2018, Fuji/Riken 2020, and let's not say anything about Histogen...

No. You are a retard if you think the source shouldn't be from the company itself.
Who else would have an estimate of time of any product in a pipeline besides the very company making it.

Also, you should research the definition of what the f*** an estimate is, those timelines given where estimates. None of those companies explicitly said that they "guarantee" they will have their products out at a certain time, there were all estimated timelines.

Companies fail all the time, doesn't mean it wasn't a "source" of information.

It's like expecting Mercedes Benz to give an estimate on the release of the new BMW. Doesn't make sense. The only source that can give the most accurate estimate would be BMW for the release of their own car. Same concept.