Lactoferrin As A Promoter Of Hair Growth

[MrsS]

Thought we had issues with the plumbing. Turns out it's this stuff. Anyone else have a pretty pongy smell from their solution?!

Yep, I'm using Life Extensions lactoferrin and the solution smells pretty nasty. I assumed it was some kind of mold growing, but even after heavily sanitizing my containers it's still there.

My solution gets smell after a day or two too...

AOV Lactoferrin doesn't smell at all. I keep the bottle refrigerated. Where do you guys store yours?

 

[bluesuedeshoes]

AOV Lactoferrin doesn't smell at all. I keep the bottle refrigerated. Where do you guys store yours?

My AOR lactoferrin solution is kept at room temp in a closet. Perhaps I should keep it in the fridge.

 

[Renegade000]

i can definitely say that my shed consists primarily of either thin miniaturized hairs or very short black hairs that are still in development to become terminal (i guess). in the meantime i occasionaly shed thick black terminal, but yes it happens as well :/

i am about to change my protocol to a high concentration zinc sulfate + saw palmetto (a powder which also dissolves in water) + lactoferrin solution.

Nice but why no B6?

 

[Renegade000]

It’s rare for a topical to be something I actually WANT systemic absorption from. Lactoderrin is great for health.

 

[Georgie]

Dunno man, too soon to conclude the shed is positive or negative. In terms of density I'm worse off than baseline, but temples and hairline are above.

Are you using minoxidil? Sounds exactly like my experience with it.

 

[MrsS]

Are you using minoxidil? Sounds exactly like my experience with it.

Not on minoxidil. I've read some anecdotes on cyclical shedding so that put me off are you still on minoxidil?

 

[whatevr]

i am not sure about the absorption. In the paper below (which i believe zix is based on) the authors claim that zinc in high concentrated form inhibited almost all 5a activity, even without b6.

https://www.ncbi.nlm.nih.gov/pubmed/3207614

Zinc mostly inhibits 5AR1 though, which is good for acne, but not gonna be much use against the 5AR2 in the DP of hair follicles...

https://www.jidonline.org/article/S0022-202X(15)42127-X/pdf

"It was somewhat surprising that type II 5a-reductase, which contains a triplet stretch of histidine residues at amino acid positions 229 to 231, and thus is more likely to bind zinc and its analogues than is type I, was not inhibited by ZnCl2 or CdCI2. "

"The results showed that type I 5a-reductase was strongly inhibited by Cd, Cu, and Zn and moderately inhibited by Ni and Fe, with 50% inhibitory concentration values of 0.9, 1.9, 2.0, 169.2, and 174.3 ILM, respectively. In contrast, type II 5a-reductase activity was inhibited only by Cu, with a 50% inhibitory concentration value of 19.2 ILM."

This is why I've always been skeptical of Zix.

 

[spring15]

When @whatevr & @Georgie are active in the vicinity you KNOW some follicles about to be woke

 

[MrsS]

Zinc mostly inhibits 5AR1 though, which is good for acne, but not gonna be much use against the 5AR2 in the DP of hair follicles...

Interesting find and might explain why Zix doesn't work for all! Could it be that Zix might work because of its anti-inflammatory properties?

And would it be interesting to add copper chloride to a growth stimulant like LF? Just thinking of ways to incorporate a 5ar II inhibitie with a growth stimulant.

 

[whatevr]

Doesn't vitamin B6 inhibit type II 5a?

https://www.ncbi.nlm.nih.gov/pubmed/1421208

This study just states that different forms either boost or inhibit it, but since I can't access the whole thing I can't really see if they specified whether it was type I or type II (if they specified at all, because some do not, like it doesn't matter).

 

[Renegade000]

i am not sure about the absorption. In the paper below (which i believe zix is based on) the authors claim that zinc in high concentrated form inhibited almost all 5a activity, even without b6.

https://www.ncbi.nlm.nih.gov/pubmed/3207614


also if you are interested i am posting this study which found that in all of the hair loss patients, the mean serum zinc was significantly lower than in the healthy control group

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870206/

I test my serum every year. One year ago, my zinc and copper were at decent levels. Last momth’s test showed deficiencies in both and my hair loss has accelerated x6 over the past year. It’s also due to my thyroid and hormonal factors as a result of metals toxicity.

I was taking 50mg zinc picolonate the entire period! I believe I have been sweating out zinc and copper with my intensive sauna regimen.

I have increased zinc to 80mg and 2,500 mcg copper.
Started using zix and I might also add cooler peptides. Copper is very importnent for hair and I wonder if it works well with zix as zinc is a copper antagonist (maybe topical zinc reduces copper in the scalp?)

 

[whatevr]

Zix seems to help for quite some help. Have you tried it?

I had issues with the topical, if it mixed with ethanol it would give me awful pain around the eyes for some reason. Even though I used it in distilled water, if I applied minoxidil later that day I'd run into trouble. In the end I did not deem it worth it to troubleshoot WTF was going on since I wasn't much of a believer that it worked anyway.

 

[MrsS]

Quick update.
Hairline and temples are still fine (where I regrew my hair on LF). But my mid frontal part, f*ck.. After washing my hair this morning I can clearly see my scalp. I regret not taking pics of my mid frontal part before starting the treatment. I had a wider than usual part, but it was fine for me

After washing my hair I sprayed a shitload of LF, waited for my hair to dry and took another pic.

View attachment 122165

P.s. i don't have a similar before LF pic. My focus was on hairline and temples, my mid part was thinning, but manageable for me....

P.p.s. deleted the pic, without a baseline it's useless to say anything about thinning. My bad.

 

[MrsS]

the above pic is the after pic then? also, do you have wet hair in the above pic?

Sorry, i forgot: above pic is wet hair this morning, below pic is dry Hair this morning (after spraying LF). I will edit the post

 

[whatevr]

Quick update.
Hairline and temples are still fine (where I regrew my hair on LF). But my mid frontal part, f*ck.. After washing my hair this morning I can clearly see my scalp. I regret not taking pics of my mid frontal part before starting the treatment. I had a wider than usual part, but it was fine for me

After washing my hair I sprayed a shitload of LF, waited for my hair to dry and took another pic.

Do you see thinning as well?
View attachment 122164

Maybe a little bit thin on (your) left side, but without seeing a pic from before, it's hard to say.

 

[MrsS]

Maybe a little bit thin on (your) left side, but without seeing a pic from before, it's hard to say.

as mentioned by whatevr, without any reference it's hard to say. but overall i think your hair looks great. on a sidenote: it will always look "more concerning" to you when wet. don't worry about that

You're right, without a decent baseline pic this comparison is useless (went a bit into panic mode). Sorry about that.

 

[Georgie]

Not on minoxidil. I've read some anecdotes on cyclical shedding so that put me off are you still on minoxidil?

Yes and the cycling is correct. Ever since June 2015, like clockwork. It’s a trap.

 

[itsjustsimon]

Yes and the cycling is correct. Ever since June 2015, like clockwork. It’s a trap.

Wat. Studies are out, if you are using minoxidil you’ll be better off if you are a responder even when you’re at the worst. That’s a fact.

 

[Derelict]

Yes and the cycling is correct. Ever since June 2015, like clockwork. It’s a trap.

is it exactly every 6 months you get the shed due to oral minoxidil?

 

[polishkickbuttowski]

My shedding is back to baseline after my one week shed. The only thing that may be different for me is that a patch on my hairline seems thinner, but idk if that's new or i just noticed it.

i recently noticed that my hair have become a bit darker in color and a little bit thicker too. however, i have clearly lost density because of the shedding. any similar obersvations?