Let's Talk About Andogen Receptor Upregulation

Samson123

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Well, I'm not young and was definitely losing hair. When I started finasteride I only had slight frontal diffuse thinning with no problems in my crown area or mid anterior area. Last year while still on 1.25 mg my DHT was at the very bottom of the range and my T levels were low too.
 

MicroDoser

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View attachment 41766 View attachment 41769 I agree with gi joey about people's actual experiences with finasteride being at odds with all the studies on the drug that everyone loves to cite. I was .5 mg for six months and I was more or less stable, I didn't notice any changes. finasteride did nothing but accelerate my hairloss and destroyed the quality of my existing hair. I have read a few accounts of hair improving somewhat after quitting and I have been slowly moving in that direction. Last month I took .5mg eod for a week, then dropped it to 3/8 of a 1 mg pill ed for a week, then 3/8 of a pill eod for a week, and then to .25 mg ed. I had been on .25 mg for one week when I buzzed to a two guard like I do every two weeks. The devastion was immediately apparent. I was shocked at how bad things had become so quickly. My existing hair had even become finer. After a buzz cut I always run my hands of my hair to feel the spikey resistance but there wasn't any. So much for the 'flat dose response' .05 mg being almost as effective as 1 mg in dht reduction. I didn't even make a radical reduction in dosage (btw, i recommend lowering the dose the way I did as it was a whole lot easier on my body. Previous attempts at reducing dosage affected me negatively, severe insomnia for a night or two). Anyway, what this shows me is that 1) finasteride isn't necessarily a flat dose response drug. 2) finasteride has made my follicles WAY more sensitive to androgens, given that a small increase in DHT over a very short period of time caused so much damage. 3) I can't quit finasteride because I would be effectively bald within a couple months and I know I couldn't handle that psychologically. The first pic (hair is slightly longer) was taken three weeks ago and the second pic one week ago.


What were your sides like? Oily skin? Acne? Increased libido?
 

Samson123

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I've experienced no side effects on finasteride so far. I'm back on .5 mg.
 

Samson123

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What happened to this thread? I'm Living proof that AR upregulation can happen and an extreme one at that and the thread just died.

It's like the elephant in the room took a huge dump and everyone just left.
 

buckthorn

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What happened to this thread? I'm Living proof that AR upregulation can happen and an extreme one at that and the thread just died.

It's like the elephant in the room took a huge dump and everyone just left.

people that have experienced this dropped finasteride and don't really care. Myself? I still f*cking care a whole f*ck ton. I am pissed that the ONLY medication for male pattern baldness not only didn't work, but made things drastically worst. I have no hope left.
 

kj6723

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people that have experienced this dropped finasteride and don't really care. Myself? I still f*cking care a whole f*ck ton. I am pissed that the ONLY medication for male pattern baldness not only didn't work, but made things drastically worst. I have no hope left.

Bro do you ever think about going the piece route? Would that be an option you'd consider?
 

buckthorn

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BaldingGuy

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I think thats what's happening to me! F#ck! I started taking fina and minoxidil a little over 6 months ago and my hair is a lot worse than before! I do feel the itching and burning sensation (the itching for the most part) and i do see hairs that taper big time towards the root that has a big white bulb! I've lost so much density in these past 6 months... Unbelieveble!
I've always blamed minoxidil for the shedding but now I'm thinking that maybe I should be blaming finasteride... I have an appointment with a hair specialist next month, but I'm afraid that my hair will be in even worse shape by then because im still losing a lot of hair everyday..
 

Armando Jose

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I think thats what's happening to me! F#ck! I started taking fina and minoxidil a little over 6 months ago and my hair is a lot worse than before! I do feel the itching and burning sensation (the itching for the most part) and i do see hairs that taper big time towards the root that has a big white bulb! I've lost so much density in these past 6 months... Unbelieveble!
I've always blamed minoxidil for the shedding but now I'm thinking that maybe I should be blaming finasteride... I have an appointment with a hair specialist next month, but I'm afraid that my hair will be in even worse shape by then because im still losing a lot of hair everyday..

Is your actual hair loss diffuse?
 

BaldingGuy

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Is your actual hair loss diffuse?

Yes, now it is! 6 months ago I went to a dermatologist because of a slight recession in my temples and a few hairs in my hairline that wouldn't grow as fast or as long as the others. It wasn't cosmetically relevant but I found it odd! Even the derm told me that in fact I had male pattern baldness but it was in the very early stages and that I did good by going this early, but since I started the treatment my hair just said bye bye... I can't even pull my usual hair style properly now !
To be honest I did change minoxidil brands 2 months ago when I went the first time to a hair specialist and he said the minoxidil i was using was leaving to much residue.... (this one leaves with what seems like dry skin that I can peel of) Maybe I cant handle minoxidil? Yeah, the areas I apply it are way thinner.. Coincidence?
On the other hand I do itch and lose hair that seems to be miniaturized where I don't apply any minoxidil so I don't know if fina is doing anything.
One thing is certain, before I started the treatment I was losing less than half the hairs I'm losing now...
 

Armando Jose

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Yes, now it is! 6 months ago I went to a dermatologist because of a slight recession in my temples and a few hairs in my hairline that wouldn't grow as fast or as long as the others. It wasn't cosmetically relevant but I found it odd! Even the derm told me that in fact I had male pattern baldness but it was in the very early stages and that I did good by going this early, but since I started the treatment my hair just said bye bye... I can't even pull my usual hair style properly now !
To be honest I did change minoxidil brands 2 months ago when I went the first time to a hair specialist and he said the minoxidil i was using was leaving to much residue.... (this one leaves with what seems like dry skin that I can peel of) Maybe I cant handle minoxidil? Yeah, the areas I apply it are way thinner.. Coincidence?
On the other hand I do itch and lose hair that seems to be miniaturized where I don't apply any minoxidil so I don't know if fina is doing anything.
One thing is certain, before I started the treatment I was losing less than half the hairs I'm losing now...

You have great problems, IMO minoxidil and finas is no a preventive method for common hair loss.
which test used your derm to determinated your Androgenetic Alopecia?
Take care
 

BaldingGuy

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He used a magnifying camera to see if I had any miniaturization which i did... Right now i'm in a crossroad!
I don't know if i should quit minoxidil or take a week off to see how my skin reacts;
Or if i should reduce it to once a day;
Or if i should keep doing the treatment for another month until the appointment;
Normally a month shouldn't be a long time but at the rate Im losing hair from the front of my head it really is!
 

proscar2

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get on ru58841, do 100mg a day for 2 months should thicken massively.

buy tempol powder an sod mimetic (do research) use this every day

but setipiprant 100 grams expensive (ish)


take 0.8 - 1.25 grams every day (and 2% topical)

do all the above at the same time. will make a massive difference

i NEVER used finasteride as it was a crap shoot works/ doesn't work/ makes thing far worse.

incidentally finasteride works only if your igf levels are high to begin with.

you shouls see a masiive difference in two months.


if you need me to go indepth why all this works pm me and ill send the info

tempol at least will stop any further hair falling out. its used to stop chemotherapy patients losing hair.
 

proscar2

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get on ru58841, do 100mg a day for 2 months should thicken massively.

buy tempol powder an sod mimetic (do research) use this every day

but setipiprant 100 grams expensive (ish)


take 0.8 - 1.25 grams every day (and 2% topical)

do all the above at the same time. will make a massive difference

i NEVER used finasteride as it was a crap shoot works/ doesn't work/ makes thing far worse.

incidentally finasteride works only if your igf levels are high to begin with.

you shouls see a masiive difference in two months.


if you need me to go indepth why all this works pm me and ill send the info

tempol at least will stop any further hair falling out. its used to stop chemotherapy patients losing hair.
 

WMQ

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get on ru58841, do 100mg a day for 2 months should thicken massively.

buy tempol powder an sod mimetic (do research) use this every day

but setipiprant 100 grams expensive (ish)


take 0.8 - 1.25 grams every day (and 2% topical)

do all the above at the same time. will make a massive difference

i NEVER used finasteride as it was a crap shoot works/ doesn't work/ makes thing far worse.

incidentally finasteride works only if your igf levels are high to begin with.

you shouls see a masiive difference in two months.


if you need me to go indepth why all this works pm me and ill send the info

tempol at least will stop any further hair falling out. its used to stop chemotherapy patients losing hair.
is that your current regimen?
 

abcdefg

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You have great problems, IMO minoxidil and finas is no a preventive method for common hair loss.
which test used your derm to determinated your Androgenetic Alopecia?
Take care

Propecia isnt a preventative method for male pattern baldness? Are you one of those guys that despite a mountain of evidence argues that the world if flat still?
Someone wants to argue the safety of propecia fine, but the fact it works is beyond arguing at this point.
 

Armando Jose

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Propecia isnt a preventative method for male pattern baldness? Are you one of those guys that despite a mountain of evidence argues that the world if flat still?
Someone wants to argue the safety of propecia fine, but the fact it works is beyond arguing at this point.

Finasteride as a Preventive method ? This medicine must be used for ever, if you are a healthy hair person dont must use this med or you can have problems

In Propecia datasheet:

www.medsafe.govt.nz/profs/Datasheet/p/Propeciatab.pdf

PROPECIA is indicated for the treatment of men with male pattern hair loss (androgenetic alopecia) to increase hair growth and prevent further hair loss.

Continued use is recommended to obtain maximum benefit. Withdrawal from the treatment leads to reversibility of effect within 12 months.
 
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