- Reaction score
- 498
The whole cetirizine thing was abandoned because some people weren't able to grasp the concept of prostaglandins. It's not that important how much PGD2 you have inhibited but what matters is how the prostaglandin ratio on the scalp tissue has changed.
Diclofenac in this case is little bit of a gamble since it works on COX inhibition and not on mast cell regulation like cetirizine. I would have some sort of concept on how I could increase PGE2 artificially (minoxidil, oral castor oil, ricinoleic acid, caffeine ginseng taurine and the list goes on) prior to thinking about messing with the COX inhibition.
I have seen people losing hair on caffeine, indomethacin (was considered a cure a while back) and other NSAIDs like aspirin.
Because they all failed to take PGE2 into consideration. Once people think something doesn't work as well, they tend to ditch it instead of looking at the treatment in several angles.
Once you grasp a concept well, you can add that to your well-grounded regimen to see more halt in hair loss or even regrowth.
In my experience PGD2 limits the vellus hairs that could've popped up even if someone is already on a well-supported treatment regime. It's up to you too increase the PGE2 levels to possibly thicken those velluses.
So, yeah, most people here a while back never had much of an understanding nor patience to evaluate and revise their plans.
PGD2 studies were barely coming out and they pretty much took a shot in the absolute dark and obviously didn't achieve what they wanted.
This is even the case for Allergan, they dropped setipiprant like nothing lol, same for Novartis.
Diclofenac in this case is little bit of a gamble since it works on COX inhibition and not on mast cell regulation like cetirizine. I would have some sort of concept on how I could increase PGE2 artificially (minoxidil, oral castor oil, ricinoleic acid, caffeine ginseng taurine and the list goes on) prior to thinking about messing with the COX inhibition.
I have seen people losing hair on caffeine, indomethacin (was considered a cure a while back) and other NSAIDs like aspirin.
Because they all failed to take PGE2 into consideration. Once people think something doesn't work as well, they tend to ditch it instead of looking at the treatment in several angles.
Once you grasp a concept well, you can add that to your well-grounded regimen to see more halt in hair loss or even regrowth.
In my experience PGD2 limits the vellus hairs that could've popped up even if someone is already on a well-supported treatment regime. It's up to you too increase the PGE2 levels to possibly thicken those velluses.
So, yeah, most people here a while back never had much of an understanding nor patience to evaluate and revise their plans.
PGD2 studies were barely coming out and they pretty much took a shot in the absolute dark and obviously didn't achieve what they wanted.
This is even the case for Allergan, they dropped setipiprant like nothing lol, same for Novartis.
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