hairregrowth21
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I read some thing about people using KGF or planning to use KGF after DRing? Did anyone use it ?
One of the arguments was that KGF can penetrate better due to DRing and the environment that comes into picture post DRing can be made more conducive for growth by using KGF.
SUPPORTING STUDY:
Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.
D. M. Danilenko, B. D. Ring, D. Yanagihara, W. Benson, B. Wiemann, C. O. Starnes, and G. F. Pierce
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Abstract
The growth and development of hair follicles is influenced by a number of different growth factors and cytokines, particularly members of the fibroblast growth factor (FGF) family. Keratinocyte growth factor (KGF or FGF-7) is a recently identified 28-kd member of the FGF family that induces proliferation of a wide variety of epithelial cells, including keratinocytes within the epidermis and dermal adnexa. Because KGF induces marked proliferation of keratinocytes, and both KGF and KGF receptor (KGFR) mRNA are expressed at high levels in skin, we sought to localize KGF and KGFR in skin by in situ hybridization. KGFR mRNA was relatively strongly expressed by keratinocytes in the basilar epidermis as well as throughout developing hair follicles of rat embryos and neonates. KGF mRNA was expressed at lower levels than was KGFR but could be localized to follicular dermal papillae in rat embryos and neonates. These results prompted us to investigate the effects of KGF on hair follicles in two distinct murine models of alopecia. In the first model, recombinant KGF (rKGF) induced dose-dependent hair growth over most of the body in nu/nu athymic nude mice when administered intraperitoneally or subcutaneously over 17 to 18 days. When administered subcutaneously, rKGF induced the most extensive hair growth at the sites of injection. Histologically, rKGF induced marked follicular and sebaceous gland hypertrophy, a normalization of the nu/nu follicular keratinization defect, and an increase in follicular keratinocyte proliferation as assessed by bromodeoxyuridine labeling. In the second model, a neonatal rat model of cytosine arabinoside chemotherapy-induced alopecia in which interleukin-1, epidermal growth factor, and acidic FGF have all demonstrated some degree of alopecia cytoprotection, rKGF induced a dose-dependent cytoprotective effect, abrogating as much as 50% of the alopecia in this model when administered beginning 1 day before the onset of chemotherapy. Taken together, these data suggest that KGF is an important endogenous mediator of normal hair follicle growth, development, and differentiation.
I added it about a month and a half ago into some cetaphil with MSM, B-12, Curcumin and most recently, garlic.
Still too early to tell for sure but I'm sure it's playing a role.
The one thing I noticed is that it says not to shake the bottle any more than 3-4 times after it's been mixed or else it will lose its potency. This would suggest that you would need to add any complementary items first and then add the KGF second, only mixing lightly and remembering not to shake before daily use.
As far as Squeegee, his informative contributions and insight will be missed. Maybe he will resurface here or elsewhere on another forum in a more controlled state one day so that he can keep fighting the battle with us. If you're reading this- thank you for your contributions, you will be missed here.