Polarityte Update (demonstrates The Broad Utility Of This Novel Product Beyond Burn Care)

[Tano1]

Why not take a biopsy from the head to heal the white dot FUE scars?

The biopsy has to be a few cm squared at minimum is what Swanson told me they’d take. So although it hasn’t been tested on cases such as ours, there is one thing that would be inevitable and that would be the biopsy scar.

So I guess the question you should ask yourself is if you’re willing to trade some white dot scars for a visible linear scar a couple of cm long. Plus the white dot scars would have to be excised as well probably through a punch.

At that point it starts looking to be too invasive to me.

 

[Hate da Bt]

Since SkinTE works as a paste, I thought the same thing about taking the biopsy and then them using their 3D platform technology to expand it and re-apply on both the area to be treated and the biopsied wound, but the turn-around for that is several hours (depending on how close you are to their facility) at the very least because the biopsy has to be sent in to them to undergo what they call polarization which is expanding the biopsy and converting it into a paste like substance. While you wait on that, your wound can’t just stay open so it has to be closed and sutures are the only way they can think of I guess which as we all know results in a scar. Wondered if it could be re-opened once you receive the SkinTE construct, but I imagine that would be too invasive as it already is a bit invasive and he didn’t give me enough time to cover more on that particular question that I asked him. Right under the scar probably wouldn’t work since you’d have to excise the scar as well and that would be a pretty big gap. Do we even have that kind of elasticity? I don’t know. Usually multiple strips are able to be taken but only because the skin has healed and elasticity can be restored to an extent.

Thanks for the reply.
Scars are already removed and resutured with the aim of reducing their size.
Wounds can remain open for a certain period of time, but that is not the case for healthy individuals, you are right.
We shall wait and see.

 

[MrV88]

The biopsy has to be a few cm squared at minimum is what Swanson told me they’d take. So although it hasn’t been tested on cases such as ours, there is one thing that would be inevitable and that would be the biopsy scar.

So I guess the question you should ask yourself is if you’re willing to trade some white dot scars for a visible linear scar a couple of cm long. Plus the white dot scars would have to be excised as well probably through a punch.

At that point it starts looking to be too invasive to me.

So the only possible way for a treatment would be to exchange FUE scars for a FUT scar that can be healed to a certain amount? Theoretically

 

[Tano1]

So the only possible way for a treatment would be to exchange FUE scars for a FUT scar that can be healed to a certain amount? Theoretically

That’s only if there is optimal (enough) hair regeneration. He told me as SkinTE stands today, would have to be “altered” to be able to provide a solution for the balding patients that could be satisfactory.

So while the biopsy can be expanded to cover a bigger defect, it’s not clear if when they expand it if hair follicles are multiplied as a result. In one swine image it showed that the swine recovered its hair, but they took a biopsy from a spot that had a ton of hair I believe.

This is for burn patients ideally, but they want to bring out derivative products to address issues such as hair too. So the only question that remains is if from the initial biopsy, does additional hair grow when the paste is applied onto the wound? Because you have to think how much hair does a person have on average per cm squared? Let’s say 90 just for the argument’s sake and they take the biopsy with the full 90 hairs. You place it on a strip scar that totals to be double that of your biopsy size, so would only those 90 hairs be extended across the whole strip being addressed? Would there be some type of factors that cause multiple follicles to grow in the paste over the whole area? Or both?

That’s what I don’t know yet since he didn’t elaborate more on that and I’m assuming they have run into some hurdles with it based on his response that they hope to clear with one of their derivative products.

 

[MrV88]

That’s only if there is optimal (enough) hair regeneration. He told me as SkinTE stands today, would have to be “altered” to be able to provide a solution for the balding patients that could be satisfactory.

So while the biopsy can be expanded to cover a bigger defect, it’s not clear if when they expand it if hair follicles are multiplied as a result. In one swine image it showed that the swine recovered its hair, but they took a biopsy from a spot that had a ton of hair I believe.

This is for burn patients ideally, but they want to bring out derivative products to address issues such as hair too. So the only question that remains is if from the initial biopsy, does additional hair grow when the paste is applied onto the wound? Because you have to think how much hair does a person have on average per cm squared? Let’s say 90 just for the argument’s sake and they take the biopsy with the full 90 hairs. You place it on a strip scar that totals to be double that of your biopsy size, so would only those 90 hairs be extended across the whole strip being addressed? Would there be some type of factors that cause multiple follicles to grow in the paste over the whole area? Or both?

That’s what I don’t know yet since he didn’t elaborate more on that and I’m assuming they have run into some hurdles with it based on his response that they hope to clear with one of their derivative products.

So in the end even they don't know how the results will be and there is a big possibility that this product has to be altered for us. Bye bye hype

 

[Tano1]

So in the end even they don't know how the results will be and there is a big possibility that this product has to be altered for us. Bye bye hype

No they know the results, he just didn’t go more in depth with me over it. There is clearly some obstacle preventing them from issuing this to balding patients, but at least he stated that they are working on it in their R & D Department right now. 1H 2018 they’ll be releasing results from these first patients that have already undergone treatment. So first we have to wait and see if we would get an acceptable cosmetic outcome in terms of skin, then we can wait on their news for hair.

 

[MrV88]

No they know the results, he just didn’t go more in depth with me over it. There is clearly some obstacle preventing them from issuing this to balding patients, but at least he stated that they are working on it in their R & D Department right now. 1H 2018 they’ll be releasing results from these first patients that have already undergone treatment. So first we have to wait and see if we would get an acceptable cosmetic outcome in terms of skin, then we can wait on their news for hair.

Still earlier than anything else

 

[dermrafok]

Still earlier than anything else

You are so wrong. @Tano1 . 1H 2018 RELEASE TO THE PUBLIC (MARKET)

https://www.nextbigfuture.com/2017/...kin-tissue-and-other-tissues-will-follow.html

Look at the pipeline. Thank you.

 

[Tano1]

You are so wrong. @Tano1 . 1H 2018 RELEASE TO THE PUBLIC (MARKET)

https://www.nextbigfuture.com/2017/...kin-tissue-and-other-tissues-will-follow.html

Look at the pipeline. Thank you.

I’ve attached their actual pipeline from their own site. The link you gave me is a random article from back in June. Their pipeline WAS initially to go into limited market release in 2018 but that was fast forwarded to now.

They have already undergone a limited commercial release. SkinTE is being used right now on patients in select burn centers (15 I think) as the link by OP states. What I was talking about with 1H 2018 is the release of their results. They will also be gradually expanding commercial availability to the entire US throughout 2018.

 

[Xaser94]

It will work on FUT scars but it requires a skin biopsy.

I had a phone conversation with Dr. Swanson who is COO and Vice President of PolarityTE over SkinTE and asked about that specifically because as you can see, I have a scar to deal with myself.

The application takes on the properties of the biopsy. So if you took a biopsy from say your back, the product can be applied to your FUT scar, but it would make the follicles present themselves at the same thickness and diameter as it was on your back. So the only reasonable area to take a biopsy from would be from your beard, a really hairy area, or from the back of your head which defeats the purpose unless it happens to result in more hair than the biopsy which he didn’t clarify on that so I’m not sure. It is good for scars though and makes the skin look indistinguishable according to them.

They did tell me they had derivative products in the making to address smaller scars and hair regeneration, but Swanson told me that for hair regeneration as SkinTE stands, would probably need to be altered to fit the needs of bald or balding patients to a point that can be satisfactory to them.

Another thing to note is that despite this regeneration, it’s not fully scarless healing. In the swine studies, It showed that the end result was a margin as they like to call it which is basically a small scar. He said that it is virtually seamless to the naked eye so I guess it would be fine if that same result translated to humans.

The biopsy is addressed with sutures as well which results in a linear scar so there’s that as well. A few cm squared biopsy can cover large areas of wounds up to 10% of your skin. So for now this treatment is ideal for burn patients who often lose large amounts of skin, but we can still hope they come up with something from their derivative products that he stated are being worked on right now in their Research and Development Department.

Wow, atleast we know they are working on something for us. Hopefully it wont need further fda trials.

 

[thomps1523]

View attachment 73522

I’ve attached their actual pipeline from their own site. The link you gave me is a random article from back in June. Their pipeline WAS initially to go into limited market release in 2018 but that was fast forwarded to now.

They have already undergone a limited commercial release. SkinTE is being used right now on patients in select burn centers (15 I think) as the link by OP states. What I was talking about with 1H 2018 is the release of their results. They will also be gradually expanding commercial availability to the entire US throughout 2018.

How difficult would I.t be to get in touch with them again for a potential Q&A? Did you catch them purely by luck, or do you have a means to get in touch with them?

 

[Tano1]

How difficult would I.t be to get in touch with them again for a potential Q&A? Did you catch them purely by luck, or do you have a means to get in touch with them?

Me and another person from a skin care group both got in touch with them and asked a variety of questions, but it took us a couple of e-mails and we set up a phone conversation. If you are trying to get answers for hair regeneration then I can just save you the time right now and tell you that you won’t be getting anything more than what I’ve already stated here. Believe me, I tried. Their main focus right now is the success of their recent market release of their SkinTE product

By all means you can ask if they have an update on their derivative product for hair regeneration, but I doubt they’d release any information on that this early. Go on their site.

 

[jamesbooker1975]

Wonder Why they put this image on their site, :

 

[That Guy]

Someone on the HLC2020 blog shared this new article, which is published by an organization who previously sang this company's praises.

https://seekingalpha.com/article/4130500-polarityte-investors-beware

Not good.

Basically, the company is the result of SIX reverse mergers over the years. Simply put, they fear that it is the next in line for a string of failed "story stocks". That is, a stock that's value is based on expected/predicted future outcomes rather than anything tangible.

Further, the company exists only because of a pending patent application. The company had no employees or operations...just the pending application.

Definitely calls their legitimacy into question.

 

[Spanishboy97]

Someone on the HLC2020 blog shared this new article, which is published by an organization who previously sang this company's praises.

https://seekingalpha.com/article/4130500-polarityte-investors-beware

Not good.

Basically, the company is the result of SIX reverse mergers over the years. Simply put, they fear that it is the next in line for a string of failed "story stocks". That is, a stock that's value is based on expected/predicted future outcomes rather than anything tangible.

Further, the company exists only because of a pending patent application. The company had no employees or operations...just the pending application.

Definitely calls their legitimacy into question.

Weren't they supposed to be operating in some hospitals already?

 

[dermrafok]

@That Guy .Maybe it's not perfect...But this need not be viewed with alarm. SkinTE is already being marketed and performed in some patients. Excellent news.

 

[Xaser94]

https://www.ptcommunity.com/wire/po...campus-and-corporate-headquarters-meet-demand

PolarityTE, Inc. (NASDAQ:COOL) today officially announced that the company has continued to expand its R&D and biomedical manufacturing capabilities and moved its corporate headquarters to a 200,000 ft2 multi-facility “PolarityTE Campus.”

Slated to open in early 2018, the new Polarity corporate campus will centralize core company departments related to basic biomedical R&D, pre-clinical research, as well as provide another site for the manufacturing of the now commercially available SkinTE™ product. The campus will also house the “Telogen Effluvium” development hub for the Company’s pipeline of products and technology derivatives of which OsteoTE™ is set for expected commercialization in late 2018.

“With the expansive addition of the new PolarityTE campus, we hope to meet the impressive demand we have already received for SkinTE, while allowing us to grow our company, develop our core pipeline tissues and further evolve our technology platforms at an even more accelerated rate,” said Dr. Denver Lough, Chief Executive Officer of PolarityTE. “Our newly integrated headquarters and manufacturing facilities underscores PolarityTE’s commitment to growing our commercial operations and capabilities nationally, as well as our continued dedication to the development of pragmatic biomedical technologies and regenerative materials.”

 

[NimuDash]

The campus will also house the “Telogen Effluvium” development hub for the Company’s pipeline of products and technology derivatives of which OsteoTE™ is set for expected commercialization in late 2018.

But Telogen Effluvium is almost always temporal. Why does it need at treatment first?
But they are doing hair and they are doing now. Good to know.

Edit: Oh wait, this is just a forum malfunction, turning T E to Telogen Effluvium.

 

[MrV88]

https://www.ptcommunity.com/wire/po...campus-and-corporate-headquarters-meet-demand

PolarityTE, Inc. (NASDAQ:COOL) today officially announced that the company has continued to expand its R&D and biomedical manufacturing capabilities and moved its corporate headquarters to a 200,000 ft2 multi-facility “PolarityTE Campus.”

Slated to open in early 2018, the new Polarity corporate campus will centralize core company departments related to basic biomedical R&D, pre-clinical research, as well as provide another site for the manufacturing of the now commercially available SkinTE™ product. The campus will also house the “Telogen Effluvium” development hub for the Company’s pipeline of products and technology derivatives of which OsteoTE™ is set for expected commercialization in late 2018.

“With the expansive addition of the new PolarityTE campus, we hope to meet the impressive demand we have already received for SkinTE, while allowing us to grow our company, develop our core pipeline tissues and further evolve our technology platforms at an even more accelerated rate,” said Dr. Denver Lough, Chief Executive Officer of PolarityTE. “Our newly integrated headquarters and manufacturing facilities underscores PolarityTE’s commitment to growing our commercial operations and capabilities nationally, as well as our continued dedication to the development of pragmatic biomedical technologies and regenerative materials.”

Seems like they do have employees

 

[Xaser94]

But Telogen Effluvium is almost always temporal. Why does it need at treatment first?
But they are doing hair and they are doing now. Good to know.

Edit: Oh wait, this is just a forum malfunction, turning T E to Telogen Effluvium.

Wow that's so weird. If I got to edit it says Telogen Effluvium not telogen effluvium. Anyone else have annoying and intrusive ads on mobile with this site as of lately?


Edit: Wtf....lmao I guess i can't say it. Everyone just read the article and find out what it really says