Pyrilutamide (KX-826) 1.0% and 0.5%
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cloudsanrain
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Just search some of the reviews in this forum. Many are not very positive about this stuff.
Can you share some?
cloudsanrain
Established Member
- Reaction score
- 114
Do the search yourself.
I think DHT is a scam.
it has nothing to do with hair loss.
That’s what the doctors tell us.
It’s all about the money.
The numbers show statistically significant and clinically meaningful hair growth outcomes, while demonstrating excellent safety. A total of 666 patients were treated for 24 weeks.
Both the 1.0% BID (i.e. twice a day) group and 0.5% BID group demonstrated statistically significant therapeutic efficacy and clinical significance relative to the placebo group. The target area non-vellus hair counts (“TAHC”) of the 1.0% BID group showed an increase of 15.33 hairs/cm2 from baseline. The TAHC of the 0.5% BID group showed an increase of 14.46 hairs/cm2 from baseline. The TAHC of the placebo group showed an increase of 4.68 hairs/cm2 from baseline.
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The half-life is approximately 6–8 hours.
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The efficacy of 826 is inferior to that of ru, so why not choose ru? Besides, both 826 and ru have drug resistance.
For me, the only advantage of this medicine is that it can be more conveniently purchased from legitimate channels as genuine products.
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The efficacy of 826 is inferior to that of ru, so why not choose ru? Besides, both 826 and ru have drug resistance.
For me, the only advantage of this medicine is that it can be more conveniently purchased from legitimate channels as genuine products.
Gemini say prylitamide is stronger that ru.
RU58841 has no published clinical safety or efficacy data in humans.
Because both RU58841 and pyrilutamide are competitive blockers, they must physically outcompete the DHT molecules already present in the scalp. If an individual has exceptionally high systemic or localised scalp DHT levels, the available dose may simply be overwhelmed. In these cases, it appears as though the body is "resistant" to the drug, when in reality, the treatment is just being outcompeted. Combining with a 5-alpha reductase inhibitor would (significantly) lower overall DHT levels in the scalp. With fewer DHT molecules present to compete, pyrilutamide can bind to the remaining androgen receptors much more effectively.
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Yes. In preclinical binding assays, pyrilutamide demonstrates significantly higher potency than other prominent androgen receptor antagonists.
Pyrilutamide has an IC50 value of 0.28 nM, which reflects an exceptionally high binding affinity for the receptor, compared to others like RU58841 (~1.1 nM). So RU58841 is ~4x less potent.
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If I'm already using finasteride, why would I need 826?
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If the effect of 826 is really that good, the first phase III clinical trial won't fail.
The second phase III clinical trial was successful.
Per Kintor, pyrilutamide has entered the new drug application stage in China. If the application is successful with Chinese regulators (similar to the US FDA and EU EMA), the company expects that it will reach commercialisation in 2027. Outside China it is sold directly to consumers as a cosmetic https://www.koshinemall.com/?sca_ref=7290283.HUfjZVF7fCV5W
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You brought up ''drug resistance'' and all I said was that in individuals who have exceptionally high systemic or localised scalp DHT levels, the available dose of pyrilutamide may simply be overwhelmed (as it physically must outcompete the DHT molecules already present in the scalp). In these cases, it appears as though the body is "resistant" to the drug, when in reality, the treatment is just being outcompeted. Combining with a 5-alpha reductase inhibitor would (significantly) lower overall DHT levels in the scalp. With fewer DHT molecules present to compete, pyrilutamide can bind to the remaining androgen receptors much more effectively. Using both together could synergise (as each has a different mechanism of action).
That said, pyrilutamide has single-agent activity, so can be used alone. https://www.hairlosstalk.com/interact/threads/pyrilutamide-kx-826-1-0-and-0-5.139682/post-2118424
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Can you share it?
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What does it mean in simple words?