Replicel 2016

[thomps1523]

Well...

https://www.hairlosstalk.com/intera...tion-of-dr-rolf-hoffmann-from-replicel.99711/


- He said that he thinks there is point of no return in Androgenetic Alopecia. That means that after some time you can’t regrow hair.

- He said that best candidates for RCH are women and men with thinning hair.

I guess I don't get that, but maybe you can explain it to me... Why is it that with Jak inhibitors individuals can go from slick bald to having hair, or in cases like the man at the bbq when he got burned... In replicell' video their concept is showing regrowth, so at what point, or why are people saying there is a point of no return?

 

[Swoop]

I guess I don't get that, but maybe you can explain it to me... Why is it that with Jak inhibitors individuals can go from slick bald to having hair, or in cases like the man at the bbq when he got burned... In replicell' video their concept is showing regrowth, so at what point, or why are people saying there is a point of no return?

AA is different... In AA basically only one type of cell gets attacked (epithelial cells) by a other type of cell. You disrupt that process and these epithelial cells start functioning again and regrowth immediately occurs pretty much to fully healthy anagen hair follicles.

Androgenetic Alopecia is something different. Degenerative processes occur over time that are stressing/damaging the hair follicle. Ultimately the hair follicle is complex mini-organ. At a certain timeframe when the engine is damaged too much the most straightforward way is to replace the whole engine instead of trying to repair it I guess. I dunno at what point this would be, this would vary across individuals.

 

[Torin]

Because AA is different. In AA basically only one type of cell gets attacked (epithelial cells) by a other type of cell. You disrupt that process and these epithelial cells start functioning again and regrowth immediately occurs pretty much to fully healthy anagen hair follicles.

Androgenetic Alopecia is something different. Degenerative processes occur over time that are stressing/damaging the hair follicle. Ultimately the hair follicle is complex mini-organ. At a certain timeframe when the engine is damaged too much the most straightforward way is to replace the whole engine instead of trying to repair it. I dunno at what point this would be, this would vary across individuals.

Yes! We need replacement. That's why I'm rooting for Tsuji and Follica respectively. Their aims are less about fixing more about regenerating a follicle from scratch. I for one love that premise. My doubt is whether such de novo hair would be robust enough to last. And in the case of Tsuji, whether the new hairs would inherit the ageing characteristics of the hair from which it is cloned. Some argue that Dolly the sheep inherited short telomeres and died younger as a result. Though the researchers behind Dolly said she did not have aged characteristics...

 

[Pray The Bald Away]

Yes! We need replacement. That's why I'm rooting for Tsuji and Follica respectively. Their aims are less about fixing more about regenerating a follicle from scratch. I for one love that premise. My doubt is whether such de novo hair would be robust enough to last. And in the case of Tsuji, whether the new hairs would inherit the ageing characteristics of the hair from which it is cloned. Some argue that Dolly the sheep inherited short telomeres and died younger as a result. Though the researchers behind Dolly said she did not have aged characteristics...

From the patents I've read, Follica relies on a the presence of thinning hair. It has something to do with interactions between existing follicles and skin cells.