Replicel Is On Fire Lately — Data In Feb.

[pegasus2]

Yep. RCH-01 is a bust.

 

[Ollie]

Ironically those who have maintenance from finasteride would get pretty solid regrowth that would last much longer but cant imagine a launch of this if the results are as bad as depicted.

 

[Fgsfds]

WAKE ME UP INSIDE

 

[pegasus2]

Ironically those who have maintenance from finasteride would get pretty solid regrowth that would last much longer but cant imagine a launch of this if the results are as bad as depicted.

It would be more of a replacement for minoxidil than finasteride. Instead of minoxidil you could get these injections every 9 months, but you'd still need finasteride. According to them it seems to work by inducing anagen in dormant follicles. So the same as minoxidil but worse. It works better in older patients because they have a higher telogen to anagen ratio, so there is more dormant hair to induce to anagen.

"The increase of hair density is thought to be due to the induction of anagen transition in existing resting hair follicles"

 

[Throwaway94]

I don't really see this as a bust other than the fact that they won't commercialise - in terms of results it'd still be a breakthrough new treatment if it were possible to have done locally every 6 months or so.

The safety data this provides paves the way for others too and it's only a matter of time before an expanded cell treatment becomes commercially available.

 

[Hairismylife]

Maybe they can cultivate enough cells for your next 20 years usage, we dunno at this moment. And don't forget Follica, I always think that in terms of regrowth, it only ranks after Tsuji and Tissuse.

 

[disfiguredyoungman]

WAKE ME UP INSIDE

CAN'T WAKE UP

 

[disfiguredyoungman]

Then they're going to take 50-150 hairs from your donor area every 9 months, and you'll never get those hairs back.

I haven't even thought of that, that's ridiculous. You will actually lose hair density for inferior temporary gains, that's just insane.

 

[Throwaway94]

Only if you consider a $900 weaker version of minoxidil along with a flight to Japan every 9 months to be a breakthrough. Then they're going to take 50-150 hairs from your donor area every 9 months, and you'll never get those hairs back. This thing is not commercially viable so that makes it a bust in my book. The technology just doesn't work as theorized. This is the proof. Tsuji and Tissuse are our only hope in the next ten years, and maybe Terskikh.

We don't know how many donor hairs they need to harvest to cultivate a solution with the concentration they trialled and how many sessions that would last. It could be that 50 donor cells provides enough for a lifetime of treament if frozen and taken as needed, especially since they diluted 6-fold to get the trial concentration. Flights to Japan are out of the question of course but if this were available locally I wouldn't hesitate to do it twice a year for sideless maintenance and very slight regrowth.

What I find odd is that the placebo patients are reported as a perfect 0 change every three months. If these people have pattern baldness surely their hair counts would drop slowly over the course of a year?

 

[vvvazvvv]

I want to be optimistic but damn this is some bad news.

I would be very happy with maintenance for like 9 months and go back to Japan again. But if you Read the paper then it said they need to do new trails and they definitely are not going to do that.

 

[Throwaway94]

50 units might be enough for one session. Unless they make a major breaktrhough they can't do more than one session with 50 units. Even at the lowest dose they are still culturing a lot of DSC cells to cover your entire scalp. Do you think they've made some magical breakthrough in cloning that Tsuji has not? This thing is dead. There is no evidence at all that it is any good for long-term maintenance. The data suggests otherwise. It is likely no better than minxodil for maintenance, which we all know can't keep up with the DHT damage for long. Even if you do it every six months you are still going to need finasteride on top of this.

You only need 5-10mL to cover a whole scalp, if they're diluting 6-fold from their original yield then one harvest of 50 grafts would last much much longer than one session.

The difference is that it probably partially undoes the damage from DHT rather than some other unknown minoxidil-like stimulation. They need to do the histological examination to see if the cells assimilate into the dormant dermal sheaths first, which was the case in the mouse study.

 

[MeDK]

We don't know how many donor hairs they need to harvest to cultivate a solution with the concentration they trialled and how many sessions that would last. It could be that 50 donor cells provides enough for a lifetime of treament if frozen and taken as needed, especially since they diluted 6-fold to get the trial concentration. Flights to Japan are out of the question of course but if this were available locally I wouldn't hesitate to do it twice a year for sideless maintenance and very slight regrowth.

What I find odd is that the placebo patients are reported as a perfect 0 change every three months. If these people have pattern baldness surely their hair counts would drop slowly over the course of a year?

Its because its calculated, so they assumed that placebo patient is the reference. It is a weird study they have done in the hair "count", I don't get why they just didn't do a count from the pictures manually, instead of a calculated value.

But they numbers compared to the original study seems a bit off somehow, maybe there is needed some more understanding from the study that haven't been given out yet. The only thing the use is the dose from the european study. So in some way, too me it doesn't seem like an extension from the first study.

 

[Ollie]

So it’s basically Tsuji / Tissuse or nothing .

 

[That Guy]

50 units might be enough for one session. Unless they make a major breaktrhough they can't do more than one session with 50 units. Even at the lowest dose they are still culturing a lot of DSC cells to cover your entire scalp. Do you think they've made some magical breakthrough in cloning that Tsuji has not? This thing is dead. There is no evidence at all that it is any good for long-term maintenance. The data suggests otherwise. It is likely no better than minxodil for maintenance, which we all know can't keep up with the DHT damage for long. Even if you do it every six months you are still going to need finasteride on top of this.

Well, the study that RepliCel did showed a sustained response after years.

Not sure why this one didn't; perhaps they fucked up somewhere, who knows.

My take on this is that I wouldn't say the technology is necessarily a bust, but the product obviously is.

All these people saying "Oh, I'd pay for it!" They don't care. You will inevitably have a limited amount of times you can get this done due to the biopsies and sh*t; for that reason alone they will not release it. There's also the fact that Follica and Tsuji will be releasing within the next couple years.

There's simply no way they can compete with that, and the procedure is (based on their current research) not a viable alternative. Follica has already shown superior results and Tsuji's tech is far more advanced and just around the corner. It can't even compete with finasteride.

Given the current happenings and forthcoming products in the same field, this is just going to be a waste of money for them to keep pursuing.

 

[Hairismylife]

Well, the study that RepliCel did showed a sustained response after years.

Not sure why this one didn't; perhaps they fucked up somewhere, who knows.

My take on this is that I wouldn't say the technology is necessarily a bust, but the product obviously is.

All these people saying "Oh, I'd pay for it!" They don't care. You will inevitably have a limited amount of times you can get this done due to the biopsies and sh*t; for that reason alone they will not release it. There's also the fact that Follica and Tsuji will be releasing within the next couple years.

There's simply no way they can compete with that, and the procedure is (based on their current research) not a viable alternative. Follica has already shown superior results and Tsuji's tech is far more advanced and just around the corner. It can't even compete with finasteride.

Given the current happenings and forthcoming products in the same field, this is just going to be a waste of money for them to keep pursuing.

Only few ppl here still remember Follica. It's the best treatment beside hair cloning, dunno why ppl here ignore it.

 

[Ollie]

Only few ppl here still remember Follica. It's the best treatment beside hair cloning, dunno why ppl here ignore it.

Because it’s a glorified wounding and minoxidil.

 

[Ollie]

But like the man said, it's the best you're going to get until hair multiplication.

Yeah unfortunately.

Its f*****g annoying that there literally isn't anything upcoming that will maintain / restore existing hair. Having to get our head shaved as diffusers to get more density put in with hair multiplication wont be ideal.

 

[That Guy]

Only few ppl here still remember Follica. It's the best treatment beside hair cloning, dunno why ppl here ignore it.

Because it's not a "high-tech" solution.

Me, I just care about what works.

If rubbing cow sh*t on your scalp was proven to grow an acceptable amount of hair back, I'd do it.

 

[Throwaway94]

50 units might be enough for one session. Unless they make a major breaktrhough they can't do more than one session with 50 units. Even at the lowest dose they are still culturing a lot of DSC cells to cover your entire scalp. Do you think they've made some magical breakthrough in cloning that Tsuji has not? This thing is dead. There is no evidence at all that it is any good for long-term maintenance. The data suggests otherwise. It is likely no better than minxodil for maintenance, which we all know can't keep up with the DHT damage for long. Even if you do it every six months you are still going to need finasteride on top of this.

Forgive me I misread, the lowest concentration was actually 1/30th of the original so one harvest with one session every 6 months would last a minimum of 15 years with appropriate storage.

 

[Paulie777]

Well, the study that RepliCel did showed a sustained response after years.

Not sure why this one didn't; perhaps they fucked up somewhere, who knows.

My take on this is that I wouldn't say the technology is necessarily a bust, but the product obviously is.

All these people saying "Oh, I'd pay for it!" They don't care. You will inevitably have a limited amount of times you can get this done due to the biopsies and sh*t; for that reason alone they will not release it. There's also the fact that Follica and Tsuji will be releasing within the next couple years.

There's simply no way they can compete with that, and the procedure is (based on their current research) not a viable alternative. Follica has already shown superior results and Tsuji's tech is far more advanced and just around the corner. It can't even compete with finasteride.

Given the current happenings and forthcoming products in the same field, this is just going to be a waste of money for them to keep pursuing.

That Guy,

You seem to talk sense. Are you optimistic about Follica? Like many, I had dismissed it as glorified needling and minoxidil. I haven’t tried needling, but from the results I’ve seen, it isn’t worth the hassle. For me, things like daily topical treatments or periodic, self-administered needling are only “worth it” if they provide consistent, noticeable results and thickening.

What makes you think Tsuji is “just around the corner”? If you had to make an educated guess, when do you think Tsuji will be available? I’m not disagreeing, by the way. I’m looking for reasons to be optimistic.