Replicel Phase II in 2015!

[distracted]

Where did Swoop say it was a bust?

He can weigh in himself, but he's said before that it's unlikely Replicel will achieve desired results because so many factors have to go right with it. Something to do with the cells idk.

 

[INT]

He can weigh in himself, but he's said before that it's unlikely Replicel will achieve desired results because so many factors have to go right with it. Something to do with the cells idk.

Can agree with this. It also depends on what we define as desired results.I highly doubt that Replicel can make someone a NW1 who is now a NW4... As I said before, I would already be happy with a treatment that could maintain the amount of hair I have now without the side effect profile of finasteride.

 

[paleocapa89]

I think Swoop said (and Replicel said it as well if I remember correctly) that Replicel's injected dermal sheath cup cells can only migrate into a follicle if that follicle is in a certain stage of it's cycle (maybe early anagen).

If that is indeed the case I don't see how could replicel revive miniaturized hair that is stuck in a permanent telogen phase. Maybe it can't

Or does miniaturized hair cycle but we can't see it?

 

[INT]

I think Swoop said (and Replicel said it as well if I remember correctly) that Replicel's injected dermal sheath cup cells can only migrate into a follicle if that follicle is in a certain stage of it's cycle (maybe early anagen).

If that is indeed the case I don't see how could replicel revive miniaturized hair that is stuck in a permanent telogen phase. Maybe it can't

Or does miniaturized hair cycle but we can't see it?

I think that the anagan phase just gets shorter... This could mean that we would have to go for multiple injections to get the desired effect.

 

[hellouser]

Guys, Replicel is going to be in Toronto at a seminar this weekend and I'm planning on attending. I've already asked my boss to take a day off and he's pretty much agreed to give me time off (I work a lot of overtime hours and weekends so I deserve it). I've already made a thread, here's the info:

http://www.hairlosstalk.com/interac...-29th-2016-Japan-Regenerative-Medicine-Market

 

[mr_robot]

The anagen phase gets shorter and shorter as the the hair follicle shrinks so in theory you would be more likely to catch miniaturized hair at the correct stage. The problem is normal anagen phase can be 2-7 years, means you are very unlikely to make existing hair take on the properties of the injected cells. You could end up with the hair transplant problem, where your miniaturized hairs come back but your existing hair is not protected and starts to miniaturize.

 

[Swoop]

Hey guys I don't think Replicel is necessarily a bust. I think it may be great, but many things have to go well for Replicel to succeed. It begins with culturing the cells without losing their actual genetic signature expression. Now look at this picture and read the right part specifically;

As everybody knows it is important to actually make a difference between a healthy hair follicle that is not affected by Androgenetic Alopecia and a hair follicle that is affected by Androgenetic Alopecia.

The dermal papilla (DP) is thought to be the master regulator niche of the hair follicle. DP size is correlated with hair follicle size. The smaller the DP, the smaller the hair follicle gets. This observation is also made in Androgenetic Alopecia (the dermal papilla niche gets smaller as you can read left in the picture).

In a healthy hair follicle cycle in telogen (resting phase), the DP moves downwards and forms a tight ball and apparently reduces in size. Now it is hypothesized that when the hair goes in an active state of growing hair again the DP recruits some cells from outside the DP niche. This may be from the dermal sheath cup, but it's not really determined yet. Apparently Replicel has data that says that DSC are attracted into hair follicles, I don't know how to interpret that and whether that was shown in humans or animal models though. Maybe someone else can.

The thing is with the recruitment that the DP recruits some cells to "replenish" itself, but enough "old" DP cells still stay in the niche. When this phase of recruitment is over the hair follicle goes in anagen again for 2+ years before it will enter catagen again followed by telogen.

This time "period" would concern me, as in frequency of injections to catch hair follicles at the right time period and subsequently you might not replace enough DP cells. There might be workarounds for this though.

Now in a miniaturized hair follicle things are a bit different than in a healthy hair follicle as one can imagine. We'll just have to wait and see I guess. This is very raw speculation, but everything has to be spot on I guess, and that's not easy at all.

 

[mr_robot]

I'm wondering if DP size increases in existing anagen hair that has been thickened with Minoxidil? If it does then I guess there is no reason that Replicel could not work.

 

[Swoop]

I'm wondering if DP size increases in existing anagen hair that has been thickened with Minoxidil? If it does then I guess there is no reason that Replicel could not work.

Good question. Indeed in any reversal of miniaturization of a hair follicle, the DP should increase in size.

I quote;

The reduction in the size of the hair follicle associated with progressive hair thinning and loss includes a failure to maintain DP cell number. In androgenetic alopecia (male pattern baldness), several observations suggest that this arises from a primary defect in the DP.

The increase in the DP cell number within a follicle can occur in part by recruitment of new cells to the DP, although proliferation of DP cells may also contribute to this expansion.

During normal physiological enlargement of follicles, new cells are recruited to the DP. The source of additional DP cells during regeneration after damage has not been characterized.

So this begs the question perhaps minoxidil just stimulates DPC itself to proliferate more intensively without any recruitment from outside the niche happening (like from telogen to anagen).

If anything we still have much to learn. For instance several observations do suggest that the primary defect stems from the DP niche in Androgenetic Alopecia, but can we really say this with 100% certainty?

What I have wondered for many times also is the fact that in a miniaturized hair follicle we are left with only a few DP cells from the 500 we once had.... Why don't they vanish all together? So many DP cells vanish, but why do some stay there?

 

[mr_robot]

What I have wondered for many times also is the fact that in a miniaturized hair follicle we are left with only a few DP cells from the 500 we once had.... Why don't they vanish all together? So many DP cells vanish, but why do some stay there?

Well if the follicle is considered an organ, the DP shrinking could be regarded as a consequence of organ malnutrition but not ultimately not death, the factors that keep the follicle alive probably never disappear completely.