RIKEN Announcement: Succeeded in Developing Tech for HF Regenerative Medicine: Study to be Published Feb 10
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“On the 10th, research teams such as RIKEN announced that they have developed a regeneration technology that cultivates hair cells collected from mice, grows them in large quantities, and transplants them into the skin of mice to regenerate them periodically. did. Until now, the mechanism of re-growth was unknown, but the cells essential for re-growth and the optimal culture conditions were identified and realized. They are also ready for clinical research on humans
Animal hair is made by an organ called the root hair follicle, and mouse hair grows in a cycle of about 3 weeks and human hair grows in a cycle of 5 to 7 years. So far, the team has succeeded in experiments to grow hair by culturing the cells that are the source of hair collected from mouse hair follicles and transplanting them into the skin to create new hair follicles.
The team individually cultivated cells that are the source of hair of multiple types, and found that cells near the surface of the skin were essential for the formation of hair follicles. In addition, we compared about 220 nutritional components given during culturing and clarified the conditions under which the ability to make hair follicles lasts the longest. When a large amount of these cells were cultured and transplanted under these conditions, about 80% of the formed hair follicles were regenerated three times or more.”
this is what we were expecting
It is the best thread in the history of this forum
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Ohayo!
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About organ technologies. They already commented that it hurt there timeline:
“According to the team, they are already ready for clinical studies to transplant into patients with alopecia to confirm their safety and efficacy. However, since the venture company that was scheduled to be implemented stopped its business due to the influence of the new corona, etc., it started soliciting cooperating companies and donations from the 10th. Team leader Takashi Tsuji said, "I want to put it to practical use as soon as possible and improve the quality of life for people suffering from hair loss."
“According to the team, they are already ready for clinical studies to transplant into patients with alopecia to confirm their safety and efficacy. However, since the venture company that was scheduled to be implemented stopped its business due to the influence of the new corona, etc., it started soliciting cooperating companies and donations from the 10th. Team leader Takashi Tsuji said, "I want to put it to practical use as soon as possible and improve the quality of life for people suffering from hair loss."
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In that case, this is amazing!!!! I think we need a proper interpretation of the implications of this study before making judgements about progress.
I still believe that speculating about the status of the company is pointless as they are things that we dont know and are beyond Tsuji's control. Theres a lot of bureacracy that we have little insight about. Id stave away from putting a timeline on anything but the study speaks for itself.
"According to the team, they are already ready for clinical studies to transplant into patients with alopecia to confirm their safety and efficacy. However, since the venture company that was scheduled to be implemented stopped its business due to the influence of the new corona, etc., it started soliciting cooperating companies and donations from the 10th. Team leader Takashi Tsuji said, "I want to put it to practical use as soon as possible and improve the quality of life for people suffering from hair loss."
So they are trying to save face saying Organ closed because of the rona. Lol, ok
And then they say they are "ready" for human clinical trials but then beg for money and partners (but according to Pegasus, Riken was so rich that Tsuji didn't have to raise any funds lololol)
But ok, good that they are going to try clinical trials in some way, even it if they are going to cut a lot of corners and it's going to be a weak attempt. Better than nothing.
Sounds incredible, one of the major problems was that follicles didn't regenerate and died.
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Im confident sure these trials weren't meant for optimization but to prove the possibility of hypothesis. So Id say not bad news at all.
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@Armando Jose now they prove cycling of hair
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80 percent of the initially “transplanted” hair cells is how I read that
This thread is so sad...
It's a little bit different, 80% of the hair completed 3 or more cycles
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I think they will now grow many hairs on single mice first and study cycling and long term hair follicle maintenance. Then human trial. They have perfected their technique now
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I wonder if they tested more than that
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I agree with yadonkey here. Furthermore, potential investors will be much more apprehensive due to COVID so RIKENs excuses are very valid. Human trials are naturally the next step since theyre technology is proven in mice. Further optimization in the mice model, in my opinion, will not trump that of the human model. So they would not be cutting corners.